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Artificial induction of lactation by hypothalamic implantation of perphenazine in virgin goats

Published online by Cambridge University Press:  01 June 2009

Georgette Vandeputte-van Messom ,
G. Peeters  and
H. Lauwers
Georgette Vandeputte-van Messom
Affiliation:
Departments of Physiology and Anatomy, Veterinary Faculty, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
G. Peeters
Affiliation:
Departments of Physiology and Anatomy, Veterinary Faculty, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
H. Lauwers
Affiliation:
Departments of Physiology and Anatomy, Veterinary Faculty, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
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Summary

Perphenazine (0·8–1mg) caused udder growth and artificial induction of lactation, when stereotaxically implanted into the median eminence of virgin female goats. Sham implantations into the median eminence or implantation of perphenazine into sites of the hypothalamus not in the immediate proximity of the median eminence were ineffective. Fourteen–twenty-two d after implantation the goats were milked for the first time. Maximal milk yields of 250–1050 ml/d were achieved 3–5 months later. Udder development and induction of lactation during the premilking period were exclusively due to the action of perphenazine. It is likely that after implantation the milking stimulus played a synergic role with perphenazine in the progressive increase and the maintenance of lactation. Apparently no side effects were caused by the drug. Implantation of small doses of perphenazine in the hypothalamus might be a suitable technique for studying the physiological effects of increased levels of endogenous prolactin in goats.

Type
Research Article
Information
Journal of Dairy Research , Volume 43 , Issue 1 , February 1976 , pp. 9 - 17
Copyright
Copyright © Proprietors of Journal of Dairy Research 1976

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References

REFERENCES

Ben-David, M., Dikstein, S. & Sulman, F. G. (1965). Proceedings of the Society of Experimental Biology 118, 265.Google Scholar
Bryant, G. D., Connan, R. M. & Greenwood, F. C. (1968). Journal of Endocrinology 41, 613.Google Scholar
Bryant, G. D., Greenwood, F. C. & Linzell, J. L. (1968). Journal of Endocrinology 40, IV.Google Scholar
Cowie, A. T., Cox, C. P., Folley, S. J., Hosking, Z. D., Naito, M. & Tindal, J. S. (1965). Journal of Endocrinology 32, 129.Google Scholar
Cowie, A. T., Knaggs, G. S. & Tindal, J. S. (1964). Journal of Endocrinology 28, 267.CrossRefGoogle Scholar
Cowie, A. T., Knaggs, G. S., Tindal, J. S. & Turvey, A. (1968). Journal of Endocrinology 40, 243.Google Scholar
Cowie, A. T. & Tindal, J. S. (1961). Journal of Endocrinology 23, 79.Google Scholar
Cowie, A. T., Tindal, J. S. & Yokoyama, A. (1966). Journal of Endocrinology 34, 185.CrossRefGoogle Scholar
Hart, I. C. (1973). Journal of Dairy Research 40, 235.Google Scholar
Johke, T. (1969). Endocrinologia Japonica 16, 179.Google Scholar
Khazen, K., Mishkinsky, J., Ben-David, M. & Sulman, F. G. (1968). Archives Internationales de Pharmacodynamie et de Thérapie 171, 251.Google Scholar
McNeilly, J. R. & Lamming, G. E. (1971). Journal of Endocrinology 50, 359.Google Scholar
Marshall, W. M. (1940). Stain Technology 15, 133.Google Scholar
Mishkinsky, J., Lajtos, Z. K. & Sulman, F. G. (1966). Endocrinology 78, 919.Google Scholar
Morag, M., Shani, J., Sulman, F. G. & Yagil, R. (1971). Journal of Endocrinology 49, 351.Google Scholar
Page, K. H. (1965). Journal of Medical Laboratory Technology 22, 224.Google Scholar
Pasteels, J. L. & Ectors, F. (1968 a). Annales d'Endocrinologie 29, 663.Google Scholar
Pasteels, J. L. & Ectors, F. (1968 b). Archives d'Anatomie, d'Histologie et d'Embryologie normales et expérimentales 51, 519.Google Scholar
Romeis, B. (1948). Makroskopische Technik. (Ed. Oldenburg, R..) München.CrossRefGoogle Scholar
Shani, J. (Mishkinsky), Cowie, A. T. & Broster, W. H. (1975). Journal of Dairy Research 42, 1.CrossRefGoogle Scholar
Tindal, J. S., Knaggs, G. S. & Turvey, A. (1968). Journal of Anatomy 103, 457.Google Scholar
Vandeputte-Van Messom, G. & Peeters, G. (1974). Archives Internationales de Pharmacodynamie et de Thérapie 211, 80.Google Scholar
Winnik, H. Z. & Tennenbaum, L. (1955). Presse Médicale 63, 1092.Google Scholar