Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-03T01:20:13.612Z Has data issue: false hasContentIssue false
  • English
  • Français

Acetate utilization by the isolated perfused guinea-pig mammary gland

Published online by Cambridge University Press:  01 June 2009

T. B. Mepham ,
S. R. Davis  and
J. R. Humphreys
T. B. Mepham
Affiliation:
Department of Physiology and Environmental Studies, University of Nottingham, Faculty of Agricultural Science, Sutton Bonington, Loughborough, Leics.
S. R. Davis
Affiliation:
Department of Physiology and Environmental Studies, University of Nottingham, Faculty of Agricultural Science, Sutton Bonington, Loughborough, Leics.
J. R. Humphreys
Affiliation:
Department of Physiology and Environmental Studies, University of Nottingham, Faculty of Agricultural Science, Sutton Bonington, Loughborough, Leics.
Get access Rights & Permissions [Opens in a new window]

Summary

Acetate uptake by isolated perfused guinea-pig mammary glands was approximately l·0 mg g−1 h−1 when perfusate acetate concentrations were in the physiological range (5–11 mg/100 ml plasma). At perfusate concentrations below this range (mean 3·62 mg/100 ml plasma) the uptake was not significantly different, but in one experiment in which the mean acetate concentration was 14·5 mg/100 ml plasma the uptake was markedly elevated. Radioactivity from Na [1-14C]acetate was incorporated into CO2 and milk and tissue fat, being largely present in C16 and C18 fatty acids. The guinea-pig is atypical of non-ruminants and similar to ruminants in respect of the blood concentration and mammary utilization of acetate.

Type
Research Article
Information
Journal of Dairy Research , Volume 43 , Issue 2 , June 1976 , pp. 197 - 203
Copyright
Copyright © Proprietors of Journal of Dairy Research 1976

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bickerstaffe, R., Annison, E. F. & Linzell, J. L. (1974). Journal of Agricultural Science 82, 71.Google Scholar
Breckenridge, W. C. & Kuksis, A. (1967). Journal of Lipid Research 8, 473.Google Scholar
Davis, S. R. (1974). Thesis, University of Nottingham.Google Scholar
Davis, S. R. & Mepham, T. B. (1972). Journal of Physiology 222, 13P.Google Scholar
Davis, S. R. & Mepham, T. B. (1974). Quarterly Journal of Experimental Physiology 59, 113.Google Scholar
Freeman, C. P., Noakes, D. E. & Annison, E. F. (1970). British Journal of Nutrition 24, 705.Google Scholar
Hardwick, D. C., Linzell, J. L. & Mepham, T. B. (1963). Biochemical Journal 87, 4P.Google Scholar
Henning, S. J. & Hird, F. J. R. (1970). British Journal of Nutrition 24, 145.Google Scholar
Jenness, R. & Sloan, R. E. (1970). Dairy Science Abstracts 32, 599.Google Scholar
Jones, E. A. (1969). Journal of Dairy Research 36, 145.Google Scholar
Linzell, J. L. (1968). Proceedings of the Nutrition Society 27, 44.Google Scholar
Linzell, J. L., Mepham, T. B., Annison, E. F. & West, C. E. (1969). British Journal of Nutrition 23, 319.Google Scholar
McBride, O. W. & Korn, E. D. (1964). Journal of Lipid Research 5, 453.Google Scholar
Mepham, T. B. & Beck, N. F. G. (1972). Comparative Biochemistry and Physiology 45 A, 273.Google Scholar
Rogers, A. W. & Moran, J. F. (1966). Analytical Biochemistry 16, 206.Google Scholar
Strong, C. R. & Dils, R. (1972). Comparative Biochemistry and Physiology 43 B, 643.Google Scholar
Strong, C. R., Forsyth, I. & Dils, R. (1972). Biochemical Journal 128, 509.Google Scholar
Sutton, J. D. & Johnson, V. M. (1969). Journal of Agricultural Science 73, 459.Google Scholar