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Effects of restriction of amino acid supply to the isolated perfused guinea-pig mammary gland

Published online by Cambridge University Press:  01 June 2009

T. Ben Mepham ,
Andrew R. Peters  and
Stephen Alexandrov
T. Ben Mepham
Affiliation:
University of Nottingham, Department of Physiology and Environmental Studies, Faculty of Agricultural Science, Sutton Bonington, Loughboroug, LE12 5ED
Andrew R. Peters
Affiliation:
University of Nottingham, Department of Physiology and Environmental Studies, Faculty of Agricultural Science, Sutton Bonington, Loughboroug, LE12 5ED
Stephen Alexandrov
Affiliation:
University of Nottingham, Department of Physiology and Environmental Studies, Faculty of Agricultural Science, Sutton Bonington, Loughboroug, LE12 5ED
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Summary

When individual essential amino acids were omitted for periods of 40–100 min from the infusate substrate solution in isolated perfused guinea-pig mammary gland experiments, uptake of methionine, tyrosine, phenylalanine, histidine and tryptophan (group 1) was significantly depressed by a mean of 49·8%, whereas the remaining essential amino acids (group 2) showed no significant decrease in uptake. During depletion periods oxidation of [14C\amino acids was increased. The possible significance of the differences in absorption between the 2 groups of amino acids is discussed.

Type
Original Articles
Information
Journal of Dairy Research , Volume 46 , Issue 1 , January 1979 , pp. 69 - 73
Copyright
Copyright © Proprietors of Journal of Dairy Research 1979

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References

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