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Effect of serotonin on the motility of smooth muscles in teats of lactating cows

Published online by Cambridge University Press:  01 June 2009

Georgette Vandeputte-Van Messom ,
Christian Burvenich  and
Georges Peeters
Georgette Vandeputte-Van Messom
Affiliation:
Department of Physiology, Faculty of Veterinary Medicine, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
Christian Burvenich
Affiliation:
Department of Physiology, Faculty of Veterinary Medicine, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
Georges Peeters
Affiliation:
Department of Physiology, Faculty of Veterinary Medicine, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
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Summary

The effects of serotonin, injected into one udder artery, on teat smooth muscle function were investigated in four lactating cows. Motility of longitudinal smooth muscles was recorded by a plethysmographic technique, and sphincter function by measuring milk leakage from the full udder. Serotonin (40, 120 and 360 μg) activated teat muscle tonicity and reduced the volume of milk leakage. The effects on longitudinal smooth muscles were reduced by mianserin and ketanserin (0·375, 1·5 and 6 mg) and by methysergide (1·5 mg). These blocking substances were also effective (0·2, 0·6 and 1·8 mg respectively) in antagonizing the inhibiting action of serotonin on milk leakage. It is suggested that serotonin effects are mediated by receptors of the S2-type.

Type
Original Articles
Information
Journal of Dairy Research , Volume 52 , Issue 3 , August 1985 , pp. 347 - 353
Copyright
Copyright © Proprietors of Journal of Dairy Research 1985

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References

REFERENCES

Aas, P. 1983 Serotonin induced release of acetylcholine from neurons in the bronchial smooth muscle of the rat. Acta Physiologica Scandinavica 117 477–480CrossRefGoogle ScholarPubMed
Bernabé, J. & Peeters, G. 1980 Studies on the motility of smooth muscles of the teats in lactating cows. Journal of Dairy Research 47 259–275CrossRefGoogle ScholarPubMed
Fuller, R. W. 1980 Pharmacology of central serotonin neurons. Annual Review of Pharmacology and Toxicology 20 111–127CrossRefGoogle ScholarPubMed
Gaddum, J. H. & Picarelli, Z. P. 1957 Two kinds of tryptamine receptors. British Journal of Pharmacology 12 323–328Google Scholar
Gonella, J. 1981 [The physiological role of peripheral serotoninergic neurons. A review.] Journal de Physiologic. 77 515–519Google ScholarPubMed
Hahn, H. L., Wilson, A. G., Graf, P. D., Fischer, S. P. & Nadel, J. A. 1978 Interactions between serotonin and efferent vagus nerves in dog lungs. Journal of Applied Physiology 44 144–149CrossRefGoogle ScholarPubMed
Hay, D. W. P. & Wadsworth, R. M. 1982 The contractile effects of 5-hydroxytryptamine on the rat isolated vas deferens. British Journal of Pharmacology 77 605–613CrossRefGoogle ScholarPubMed
Hebb, C. & Linzell, J. L. 1970 Innervation of the mammary gland. A histochemical study in the rabbit. Histochemical Journal 2 491–505CrossRefGoogle ScholarPubMed
Leysen, J. E., Gommeren, W. & De Clerck, F. 1983 3H-Ketanserin labels serotonin S2-receptor binding sites on cat blood platelets. Archives Internationales de Pharmacodynamire et de Thérapie 263 322–324Google ScholarPubMed
Linzell, J. L. 1956 Evidence against a parasympathetic innervation of the mammary gland. Journal of Physiology 133 66–67PGoogle Scholar
Linzell, J. L. 1974 Mammary blood flow and methods of identifying and measuring precursors of milk. In Lactation vol. 1, pp. 143–225 (Eds Larson, B. L. and Smith, V. R.) New York: Academic PressGoogle Scholar
Marin, J., Salaices, M. & Sanchez, C. F. 1979 Release of (3H) noradrenaline induced by 5-hydroxytryptamine from cat pial arteries. Journal of Pharmacy and Pharmacology 31 818–821CrossRefGoogle ScholarPubMed
Oriowo, M. A. 1981 Direct and indirect actions of 5-hydroxytryptamine in the rat anococcygeus muscle. Archives Internationales de Pharmacodynamie et de Thérapie 254 13–19Google ScholarPubMed
Peeters, G. & De Bruycker, R. 1975 Influence of sympathomimetic drugs on the motility of bovine teat muscles. Journal of Dairy Research 42 11–19CrossRefGoogle ScholarPubMed
Vaage, J. 1976 Vagal reflexes in the bronchoconstrietion occurring after induced intravascular platelet aggregation. Acta Physiologica Scandinavica 97 94–103CrossRefGoogle ScholarPubMed
Vandeputte-Van Messom, G., Bernabé, J., Burvenich, C. & Peeters, G. 1982 Effects of α-blocking agents on teat motility in lactating cows. Archives Internationales de Pharmacodynamie et de Thérapie 260 309–311Google ScholarPubMed
Vandeputte-Van Messom, G., Bernabé, J., Burvenich, C. & Peeters, G. 1984 a Effect of prazosin on the function of the teat sphincter in lactating cows. Journal of Dairy Research 51 219–226CrossRefGoogle ScholarPubMed
Vandeputte-Van Messom, G., Burvenich, C. & Peeters, G. 1984 b Action of epinephrine on the function of the teat sphincter in the lactating cow. American Journal of Veterinary Research 45 2145–2149Google ScholarPubMed
Van Nueten, J. M., Janssen, P. A. J., Van Beek, J., Xhonneur, R., Verbeuren, T. J. & Vanhoutte, P. M. 1981 Vascular effects of ketanserin (R41468), a novel antagonist of 5-HT2serotonergic receptors. Journal of Pharmacology and Experimental Therapy 218 217–230Google ScholarPubMed