Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-29T19:16:45.306Z Has data issue: false hasContentIssue false

Biologically active peptides of casein and lactotransferrin implicated in platelet function

Published online by Cambridge University Press:  01 June 2009

Anne-Marie Fiat
Affiliation:
Laboratoire des Protéines UA CNRS U88, Université de Paris V, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France
Sylviane Levy-Toledano
Affiliation:
Hôpital Lariboisière, INSERM U 150 and CNRS LA 334, 6 rue Guy Patin, F-75475 Paris Cedex 10, France
Jacques P. Caen
Affiliation:
Hôpital Lariboisière, INSERM U 150 and CNRS LA 334, 6 rue Guy Patin, F-75475 Paris Cedex 10, France
Pierre Jollès
Affiliation:
Laboratoire des Protéines UA CNRS U88, Université de Paris V, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France

Summary

Casein and other milk proteins in maternal colostrum and milk, the earliest food of the newborn, should not only be considered as a nutritional supply but also as a source of biologically active peptides. Some of them isolated from casein and lactotransferrin were active on platelet function. They inhibited both aggregation of ADP-treated platelets and binding of [125I] fibrinogen to ADP-treated platelets. Their behaviour was compared to that of fibrinogen peptides possessing similar effects: once more similarities between the milk and blood-clotting phenomena could be observed.

Type
Original Articles
Copyright
Copyright © Proprietors of Journal of Dairy Research 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Jollès, P., Alais, C. & Jollès, J. 1961 Etude comparée des caséinoglycopeptides formés par action de la présure sur les caséines de vache, de brebis et de chèvre. I. Etude de la partie peptidique. Biochimica et Biophysica Acta 51 309314CrossRefGoogle Scholar
Jollès, P. 1975 Structural aspects of the milk clotting process. Comparative features with the blood clotting process. Molecular and Cellular Biochemistry 7 7385CrossRefGoogle ScholarPubMed
Jollès, P. & Henschen, A. 1982 Comparison between the clotting of blood and milk. Trends in Biochemical Science 7 325328CrossRefGoogle Scholar
Jollès, P., Levy-Toledano, S., Fiat, A.-M., Soria, C., Gillessen, D., Thomaidis, A., Dunn, F. W. & Caen, J. P. 1986 Analogy between fibrinogen and casein. Effect of an undecapeptide isolated from κ-casein on platelet function. European Journal of Biochemistry 158 379382CrossRefGoogle ScholarPubMed
Jollès, P., Loucheux-Lefebvre, M. H. & Henschen, A. 1978 Structural relatedness of κ-casein and fibrinogen γ-chain. Journal of Molecular Evolution 11 271277CrossRefGoogle ScholarPubMed
Kloczewiak, M., Timmons, S., Lukas, T. J. & Hawiger, J. 1984 Platelet receptor recognition site on human fibrinogen synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the γ-chain. Biochemistry 23 17671774CrossRefGoogle Scholar
Plow, E. F., Marguerir, G. & Ginsberg, M. 1987 Fibrinogen, fibrinogen receptors and the peptides that inhibit these interactions. Biochemical Pharmacology 36 40354040CrossRefGoogle ScholarPubMed
Plow, E. F., Srouji, A. H., Meyer, D., Marguerie, G. & Ginsberg, M. H. 1984 Evidence that three adhesive proteins interact with a common recognition site on activated platelets. Journal of Biological Chemistry 259 53885391CrossRefGoogle ScholarPubMed
Raha, S., Dosquet, C., Abgrall, J. F., Jollès, P., Fiat, A.-M. & Caen, J. P. 1988 Lys-Arg-Asp-Ser – a tetrapeptide derived from lactotransferrin inhibits binding of monoclonal antibody against glycoprotein llb-llla on ADP-stimulated platelets and megakaryocytes. Blood 72 172178CrossRefGoogle Scholar