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Acetate utilization by the isolated perfused guinea-pig mammary gland

Published online by Cambridge University Press:  01 June 2009

T. B. Mepham ,
S. R. Davis  and
J. R. Humphreys
T. B. Mepham
Affiliation:
Department of Physiology and Environmental Studies, University of Nottingham, Faculty of Agricultural Science, Sutton Bonington, Loughborough, Leics.
S. R. Davis
Affiliation:
Department of Physiology and Environmental Studies, University of Nottingham, Faculty of Agricultural Science, Sutton Bonington, Loughborough, Leics.
J. R. Humphreys
Affiliation:
Department of Physiology and Environmental Studies, University of Nottingham, Faculty of Agricultural Science, Sutton Bonington, Loughborough, Leics.
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Summary

Acetate uptake by isolated perfused guinea-pig mammary glands was approximately l·0 mg g−1 h−1 when perfusate acetate concentrations were in the physiological range (5–11 mg/100 ml plasma). At perfusate concentrations below this range (mean 3·62 mg/100 ml plasma) the uptake was not significantly different, but in one experiment in which the mean acetate concentration was 14·5 mg/100 ml plasma the uptake was markedly elevated. Radioactivity from Na [1-14C]acetate was incorporated into CO2 and milk and tissue fat, being largely present in C16 and C18 fatty acids. The guinea-pig is atypical of non-ruminants and similar to ruminants in respect of the blood concentration and mammary utilization of acetate.

Type
Research Article
Information
Journal of Dairy Research , Volume 43 , Issue 2 , June 1976 , pp. 197 - 203
Copyright
Copyright © Proprietors of Journal of Dairy Research 1976

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References

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