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2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy

Published online by Cambridge University Press:  21 November 2018

Mackenzie Newman ,
Janelle Stricker  and
Han-Gang Yu
Mackenzie Newman
Affiliation:
Department of Physiology, Pharmacology, and Neuroscience, West Virginia University, Morgantown, WV, USA
Janelle Stricker
Affiliation:
Department of Physiology, Pharmacology, and Neuroscience, West Virginia University, Morgantown, WV, USA
Han-Gang Yu
Affiliation:
Department of Physiology, Pharmacology, and Neuroscience, West Virginia University, Morgantown, WV, USA
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Abstract

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OBJECTIVES/SPECIFIC AIMS: Objectives: To determine genes that are shared between human and obese Zucker rat hypertrophic hearts, in order to identify potential early biomarkers and drug target for heart failure. METHODS/STUDY POPULATION: Four age-paired lean and obese Zucker rats were used. The human data are derived from doi:10.1152/physiolgenomics.00122.2016. RESULTS/ANTICIPATED RESULTS: We expect to find genes that are upregulated and downregulated in Zucker rats and humans that present cardiac hypertrophy. DISCUSSION/SIGNIFICANCE OF IMPACT: The genes and proteins determined from this study will provide future directions in order to determine whether obese Zucker rats are a valid model organism for the development of cardiac hypertrophy.

Type
Basic/Translational Science/Team Science
Information
Journal of Clinical and Translational Science , Volume 2 , Supplement S1 , June 2018 , pp. 11
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Association for Clinical and Translational Science 2018