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19 Development of the Puerto Rico Neoplasm and CNS Tumor Registry (PUNCTURE)

Published online by Cambridge University Press:  24 April 2023

Julio Rosado Philippi
Affiliation:
School of Medicine, University of Puerto Rico-Medical Sciences Campus
Natasha L. Frontera
Affiliation:
School of Medicine, University of Puerto Rico-Medical Sciences Campus
Aixa de Jesus Espinosa
Affiliation:
School of Medicine, University of Puerto Rico-Medical Sciences Campus
Valerie Wojna
Affiliation:
Neurosurgery Section, University of Puerto Rico-Medical Sciences Campus
David Blas Boria
Affiliation:
Department of Neurology, University of Puerto Rico-Medical Sciences Campus
Juan L. Parez-Berenguer
Affiliation:
Department of Pathology, University of Puerto Rico-Medical Sciences Campus
Kimberly Hoang
Affiliation:
School of Medicine, Emory University
Ali Alawieh
Affiliation:
Department of Neurosurgery, Emory University
Miguel Mayol Del Valle
Affiliation:
School of Medicine, Department of Neurosurgery MD, University of Puerto Rico-Medical Sciences Campus, Neurosurgery Section
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Abstract

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OBJECTIVES/GOALS: To describe and compare clinical data and outcomes for patients with CNS tumors and tumor mimics in Puerto Rico who are undergoing surgical and nonsurgical management. Thus, increasing data from an underrepresented group which can serve as a foundation for investigating determinants of outcomes. METHODS/STUDY POPULATION: This proposal will examine patient charts, radiology and pathology reports, financial data, and treatment details from the electronic medical record of patients receiving surgical and nonsurgical treatment for CNS tumors and mimics in the University of Puerto Rico Medical Sciences Campus and all associated institutions. Data will be analyzed retrospectively between January 1, 2014 and June 30, 2022, and prospectively for ten years until December 31, 2032. Patients with primary and metastatic CNS tumors and tumor mimics in the brain, meninges, ventricles, spinal cord, cranial nerves, orbit, facial sinuses, bony skull, vasculature will be included. The registry will include patients from birth onward. RESULTS/ANTICIPATED RESULTS: We plan to compare different surgical and non-surgical techniques and devices in terms of technical and clinical outcomes after surgical interventions for CNS tumors. We are collaborating with the CNS Tumor Outcome Registry at Emory (CTORE) and plan to continue collaboration with other institutions. Combining our data, we aim to develop predictive models of patient outcomes after surgical and nonsurgical intervention for CNS pathologies using supervised and unsupervised machine learning strategies. DISCUSSION/SIGNIFICANCE: There is a significant lack of literature on CNS intervention outcomes in Puerto Rico. This registry will provide the platform for cost-analysis studies for techniques and clinical protocols applicable to pre-operative, intra-operative, post-operative, and conservative management of patients, in Puerto Rico and beyond.

Type
Biostatistics, Epidemiology, and Research Design
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Author(s), 2023. The Association for Clinical and Translational Science