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Genetics and Child Psychiatry: I Advances in Quantitative and Molecular Genetics

Published online by Cambridge University Press:  01 January 1999

Michael Rutter
Affiliation:
Institute of Psychiatry, London, U.K.
Judy Silberg
Affiliation:
Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, U.S.A.
Thomas O'Connor
Affiliation:
Institute of Psychiatry, London, U.K.
Emily Simonoff
Affiliation:
Guy's Hospital, London, U.K.
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Abstract

Advances in quantitative psychiatric genetics as a whole are reviewed with respect to conceptual and methodological issues in relation to statistical model fitting, new genetic designs, twin and adoptee studies, definition of the phenotype, pervasiveness of genetic influences, pervasiveness of environmental influences, shared and nonshared environmental effects, and nature–nurture interplay. Advances in molecular genetics are discussed in relation to the shifts in research strategies to investigate multifactorial disorders (affected relative linkage designs, association strategies, and quantitative trait loci studies); new techniques and identified genetic mechanisms (expansion of trinucleotide repeats, genomic imprinting, mitochondrial DNA, fluorescent in-situ hybridisation, behavioural phenotypes, and animal models); and the successful localisation of genes.

Type
Research Article
Copyright
© 1999 Association for Child Psychology and Psychiatry

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