Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-23T08:41:16.313Z Has data issue: false hasContentIssue false
  • English
  • Français

A Study of Heterozygote Arrays in Relation to the Age Distribution of An Australian Population Sample

Published online by Cambridge University Press:  31 July 2008

C. J. Brackenridge
C. J. Brackenridge
Affiliation:
Department of Psychiatry, University of Melbourne, Victoria, Australia
Get access Rights & Permissions [Opens in a new window]

Summary

To explore the relation between arrays of multiple genetic systems and the age structure of a population, twelve plasma and red blood-cell polymorphisms were considered in combination. A comparison of observed and expected numbers of persons sharing an array indicated that 72·1% of arrays were in excess of expectation, largely due to association between over-representation and simple heterozygosity score. There was evidence of association between heterozygote excess and age, the proportion of over-represented arrays falling with increase in age. Some implications of this result are discussed.

Type
Research Article
Information
Journal of Biosocial Science , Volume 13 , Issue 2 , April 1981 , pp. 203 - 208
Copyright
Copyright © 1981, Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Berkson, J. (1953) A statistically precise and relatively simple method of estimating the bio-assay with quantal response, based on the logistic function. J. Am. statist. Ass. 48, 565.Google Scholar
Brackenridge, C.J. (1978) A study of phenotypic arrays derived from seven genetic systems in an Australian population sample. Ann. hum. Biol. 5, 381.CrossRefGoogle Scholar
Brackenridge, C.J., Case, J. & Sheehy, A.J. (1975) Distributions, sex and age effects, and associations between phenotypes of 14 genetic systems in an Australian population sample. Hum.Hered. 25, 520.Google Scholar
Brackenridge, C.J., Case, J. & Sheehy, A.J. (1976) The relation of birth rank and parental age to the phenotype distributions of 14 genetic systems in an Australian population sample. Hum. Hered. 26, 154.CrossRefGoogle Scholar
Edwards, J.H. (1965) The meaning of the associations between blood groups and disease. Ann. hum. Genet. 29, 77.CrossRefGoogle Scholar
Ford, E.B. (1975) Ecological Genetics, 4th edn, p. 124.Chapman & Hall, London.Google Scholar
Mantel, N. & Haenszel, W. (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J. natl Cancer Inst. 22, 719.Google Scholar
Sørenson, H. & Dissing, J. (1975) C3 polymorphism in relation to age. Hum. Hered. 25, 284.Google Scholar