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Sex linked versus autosomal inbreeding coefficient in close consanguineous marriages in the Basque country and Castile (Spain): genetic implications

Published online by Cambridge University Press:  31 July 2008

R. Calderón ,
B. Morales ,
J. A. Peña  and
J. Delgado
R. Calderón
Affiliation:
Department of Animal Biology and Genetics, Faculty of Sciences, University of Basque Country, Bilbao, Spain
B. Morales
Affiliation:
Department of Animal Biology and Genetics, Faculty of Sciences, University of Basque Country, Bilbao, Spain
J. A. Peña
Affiliation:
Department of Animal Biology and Genetics, Faculty of Sciences, University of Basque Country, Bilbao, Spain
J. Delgado
Affiliation:
Department of Animal Biology and Genetics, Faculty of Sciences, University of Basque Country, Bilbao, Spain
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Summary

Pedigree structures of 161 uncle/niece-aunt/nephew and 4420 first cousin consanguineous marriages registered during the 19th and 20th centuries in two large and very different Spanish regions have been analysed and their genetic consequences evaluated. The frequencies of the different pedigree subtypes within each degree of relationship were quite similar in both populations despite significant heterogeneity in inbreeding patterns. The mean X-linked inbreeding coefficient (Fx) for each type of cousin mating was calculated and compared to that expected for autosomal genes (F). The effect of genealogical structure on the Fx/F radio was compared to different cultural populations worldwide. Preferentiality and avoidance of close consanguinity along with specific types of pedigrees are discussed on the basis of premarital migration and sociocultural rules still deeply rooted in certain human groups. By admitting that the observed Fx coefficient is usually higher than F in most human populations some remarks have been made in terms of population genetic risk.

Type
Research Article
Information
Journal of Biosocial Science , Volume 27 , Issue 4 , October 1995 , pp. 379 - 391
Copyright
Copyright © Cambridge University Press 1995

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