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Neuroendocrine control of lactational infertility

Published online by Cambridge University Press:  27 September 2011

John E. Tyson
John E. Tyson
Affiliation:
Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
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Summary

An ever-changing secretory pattern of pituitary gonadotrophins and prolactin has been observed in puerperally lactating women. Studies in our laboratory suggest such changes are under neurogenic control via the breast. This in turn alters hypothalamic function. Endocrine profiles in lactating women obtained over 10 hours indicate that prolactin secretion and, to a lesser extent, LH secretion, are directly related to the duration and intensity of the suckling stimulus. Thus, lactation performance governs pituitary-ovarian function. Other investigators have shown that alterations in hypothalamic catecholamine turnover represents the interface between nipple stimulation and subsequent pituitary hormone secretion. Although further work is necessary to elucidate the exact neuroendocrine pathways involved, full lactation will effectively delay the restoration of cyclic gonadotrophin secretion and ovulation.

Type
I. Lactational infertility
Information
Journal of Biosocial Science , Volume 9 , supplement S4: Fertility Regulation During Human Lactation , 1977 , pp. 23 - 39
Copyright
Copyright © Cambridge University Press 1977

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References

Andreassen, B. & Tyson, J.E. (1976) Role of the hypothalamic-pit uitary-ovarian axis in puerperal infertility. J. clin. Endocr. Metab. 42, 1114.CrossRefGoogle ScholarPubMed
Birge, C.A., Jacobs, L.S., Hammer, C.T. & Daughaday, W.H(1970) Catecholamine inhibition of prolactin secretion by isolated rat adenohypophyses Endocrinology, 86, 120.CrossRefGoogle ScholarPubMed
Brun del Re, R., del Pozo, E., de Grandi, E., Friesen, H., Hinselmann, M. & Wyss, H. (1973) Prolactin inhibition and suppression of puerperal lactation by a Br-ergocryptine (CB-154). Obstet. Gynec. N. Y. 41, 884.Google Scholar
Delvoye, P., Delogne-Desnoeck, J. & Robyn, C. (1976) Serum prolactin in long-lasting lactational amenorrhoea. Lancet, ii, 288.CrossRefGoogle Scholar
Donoso, A.O., Bishop, W., Fawcett, C.P., Krulich, L. & McCann, S.M. (1971) Effects of drugs that modify brain monoamine concentrations on plasma gonadotropin and prolactin levels in the rat. Endocrinology, 89, 774.CrossRefGoogle ScholarPubMed
Grosvenor, C.E. (1964) Lactation in rat mammary glands after spinal cord section. Endocrinology, 74, 548.CrossRefGoogle ScholarPubMed
Grosvenor, C.E. & Mena, F. (1967) Effect of auditory, olfactory and optic stimuli upon milk ejection and suckling-induced release of prolactin in lactating rats. Endocrinology, 80, 840.CrossRefGoogle ScholarPubMed
Kamberi, I.A., Mical, R.S. & Porter, J.C. (1971) Pituitary portal vessel infusion of hypothalamic extract and release of LH, FSH and prolactin. Endocrinology, 88, 1294.CrossRefGoogle ScholarPubMed
Leppalüoto, J., Mannisto, P., Ranta, T. & Linnoila, M. (1976) Inhibition of mid-cycle gonadotrophin release in healthy women by pimozide and fusaric acid. Acta endocr., Copenh. 81, 455.Google ScholarPubMed
Lu, K. H., Chen, H.T., Huang, H.H., Grandison, L., Marshall, S. & Meites, J. (1976) Relation between prolactin and gonadotrophin secretion in post-partum lactating rats. J. Endocr. 68, 241.CrossRefGoogle ScholarPubMed
Macleod, R.M. & Lehmeyer, J.E. (1974a) Restoration of prolactin synthesis and release by the administration of monoaminergic blocking agents to pituitary tumor-bearing rats. Cancer Res. 34, 345.Google ScholarPubMed
Macleod, R.M. & Lehmeyer, J.E. (1974b) Studies on the mechanism of the dopamine-mediated inhibition of prolactin secretion. Endocrinology, 94, 1077.CrossRefGoogle ScholarPubMed
Maneckjee, R., Srinath, B.K. & Moudgal, N.R. (1976) Prolactin suppresses release of luteinizing hormone during lactation in the monkey. Nature, Lond. 262, 507.CrossRefGoogle ScholarPubMed
McNatty, K.P. & Sawyers, R.S. (1975) Relationship between the endocrine environment within the Graafian follicle and the subsequent rate of progesterone secretion by human granulosa cells in vitro. J. Endocr. 66, 391.CrossRefGoogle ScholarPubMed
McNatty, K.P., Sawyers, R.S. & Mcneilly, A.S. (1974) A possible role for prolactin in control of steroid secretion by the human Graafian follicle. Nature, Lond. 250, 653.CrossRefGoogle ScholarPubMed
Meites, J. (1974) Neuroendocrinology of lactation. J. invest. Derm. 63, 119.CrossRefGoogle ScholarPubMed
Nakano, R., Kayashima, F., Mori, A., Kotsuji, F., Hashiba, N. & Tojo, S. (1974) Gonadotropin response to luteinizing hormone releasing factor (LRF) in puerperal women. Acta obstet. gynec. scand. 53, 303.CrossRefGoogle ScholarPubMed
Potter, R.G. (1963) Birth intervals: structure and change. Popul. Stud. 17, 155.CrossRefGoogle Scholar
Robyn, C, Delvoye, P., Nokin, J., Vekemans, M., Badawi, M., Perez-Lopez, F.R. & L'Hermite, M. (1974) Prolactin and human reproduction. In: Human Prolactin. Edited by Pasteels, J. L. & Robyn, C.. Excerpta Medica, Amsterdam.Google Scholar
Rolland, R. & Schellekens, L. (1973) A new approach to the inhibition of puerperal lactation. J. Obstet. Gynec. Br. Commonw. 80, 945.CrossRefGoogle Scholar
Schams, D. (1976) Hormonal control of lactation. In: Breast-feeding and the Mother. Edited by Elliott, K. & FitzSimons, D. W.. Excerpta Medica, North-Holland, Amsterdam.Google Scholar
Tolis, G., Guyda, H., Pillorger, R. & Friesen, H.G. (1974) Breast-feeding: effects on the hypothalamic pituitary gonadal axis. Endocrine Res. Commun. 1, 293.CrossRefGoogle Scholar
Tyson, J.E. (1977) Nursing and prolactin secretion: principal determinants in the mediation of puerperal infertility. In: Prolactin and Human Reproduction. Edited by Crosignani, P. G. & Robyn, C.. Academic Press, London.Google Scholar
Tyson, J.E., Freedman, R.S., Perez, A., Zacur, H.A. & Zanartu, J. (1976a) Significance of the secretion of human prolactin and gonadotropin for puerperal lactational infertility. In: Breast-feeding and the Mother. Edited by Elliott, K. & FitzSimons, D. W.. Excerpta Medica, North-Holland, Amsterdam.Google Scholar
Tyson, J.E., Friesen, H.G. & Anderson, M.S. (1972a) Human lactational and ovarian response to endogenous prolactin release. Science, N. Y. 177, 897.CrossRefGoogle ScholarPubMed
Tyson, J.E., Hwang, P., Guyda, H. & Friesen, H.G. (1972b) Studies of prolactin secretion in human pregnancy. Am. J. Obstet. Gynec. 113, 14.CrossRefGoogle ScholarPubMed
Tyson, J.E., Khojandi, M., Huth, J. & Andreassen, B. (1974) The influence of prolactin secretion on human lactation. J. din. Endocr. Metab. 40, 764.CrossRefGoogle Scholar
Tyson, J.E., Perez, A. & Zanartu, J. (1976b) Human lactational response to oral thyrotropin releasing hormone. J. din. Endocr. Metab. 43, 760.CrossRefGoogle ScholarPubMed
Voogt, J.L. & Carr, L.A. (1974) Plasma prolactin levels and hypothalamic catecholamine synthesis during suckling. Neuroendocrinology, 16, 108.CrossRefGoogle ScholarPubMed
Vorherr, H. (1974) The Breast: Morphology, Physiology, and Lactation. Academic Press, New York.Google Scholar
Zarate, A., Canales, E.S., Soria, J., Ruiz, F. & Macgregor, C. (1972) Ovarian refractoriness during lactation in women: effect of gonadotropin stimulation. Am. J. Obstet. Gynec. 112, 1130.CrossRefGoogle ScholarPubMed
Zarate, A., Villalobos, H., Canales, E.S., Soria, J., Arcovedo, F. & MacGregor, C. (1976) The effect of oral administration of thyrotropin releasing hormone on lactation. J. clin. Endocr. Metab. 43, 301.CrossRefGoogle ScholarPubMed