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Antenatal genetic diagnosis in Newcastle: experience of 1200 requests

Published online by Cambridge University Press:  31 July 2008

A. R. Boon
Affiliation:
Department of Human Genetics, University of Newcastle upon Tyne

Summary

A consecutive series of 1200 specimens of amniotic fluid obtained by amniocentesis from patients requesting antenatal diagnosis coming to a regional genetic advisory service is reviewed. The analysis identifies the conditions that most frequently come for antenatal diagnosis, picks out the conditions showing the highest frequency of affected fetuses on termination, and examines the success of the procedure as regards the accuracy of the genetic diagnosis and the ensuing normality of the pregnancy.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1981

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References

Editorial (1978) Br. med. J. 2,1661.CrossRefGoogle Scholar
Ferguson-Smith, M.A., Benson, P.F., Brock, D.J.H., Fairweather, D.V.I., Harris, R., Laurence, K.M., McDermott, A., Patrick, A.D., Polani, P.E. & Walker, S. (1978) The provision of services for the prenatal diagnosis of fetal abnormality in the United Kingdom. Bull. Eugen. Soc. Suppl. 3.Google Scholar
Golbus, M.C., Loughman, W.D., Epstein, C.J., Halbasch, G., Stephens, J.D. & Hall, B.D. (1979) Prenatal genetic diagnosis in 3000 amniocenteses. New Engl. J. Med. 300,157.CrossRefGoogle ScholarPubMed
Medical Research Council (1978) Working party on amniocentesis report; an assessment of the hazards of amniocentesis. Br. J. Obstet. Gynaec. 85, Suppl. 2.Google Scholar
Mennuitti, M.T., Brummond, W., Crombleholme, W.R., Schwartz, R.M. & Arvan, D.A. (1980) Fetal-maternal bleeding associated with genetic amniocentesis. Obstet. Gynec. N.Y. 55,48.Google Scholar
Polani, P.E., Alberman, E., Alexander, B.J., Benson, P.F., Berry, A.C., Blunt, S., Daker, M.G., Fensom, A.H., Garrett, D.M., Mcguire, V.M., Fraser Roberts, J.A., Sellers, M.J. & Singer, J.D. (1979) Sixteen years' experience of counselling, diagnosis, and prenatal detection in one genetic centre: progress, results, and problems. J. med. Genet. 16, 166.Google Scholar
Webb, T., Edwards, J.H., Cameron, A.H., Crawley, J.M., Hulten, M.A.J., Rushton, D.I. & Thompson, R.A. (1980) Amniocentesis in the West Midlands: report on 1000 births. J. med. Genet. 17,81.CrossRefGoogle Scholar