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Marriage patterns in Sri Lanka and the prevalence of parental consanguinity in patients with β-thalassaemia: a cross-sectional descriptive analysis

Published online by Cambridge University Press:  25 October 2019

Anuja P. Premawardhena ,
Shamila T. De Silva Open the ORCID record for Shamila T. De Silva [Opens in a new window] ,
M. D. Dilith C. Goonatilleke ,
Dileepa S. Ediriweera ,
Sachith Mettananda ,
B. K. Rexan P. Rodrigo ,
Angela Allen  and
David J. Weatherall
Anuja P. Premawardhena*
Affiliation:
Faculty of Medicine, University of Kelaniya, Sri Lanka
Shamila T. De Silva
Affiliation:
Faculty of Medicine, University of Kelaniya, Sri Lanka
M. D. Dilith C. Goonatilleke
Affiliation:
Faculty of Medicine, University of Kelaniya, Sri Lanka
Dileepa S. Ediriweera
Affiliation:
Faculty of Medicine, University of Kelaniya, Sri Lanka
Sachith Mettananda
Affiliation:
Faculty of Medicine, University of Kelaniya, Sri Lanka
B. K. Rexan P. Rodrigo
Affiliation:
Faculty of Medicine, University of Kelaniya, Sri Lanka
Angela Allen
Affiliation:
Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
David J. Weatherall
Affiliation:
Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
*
*Corresponding author. Email: [email protected]
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Abstract

Consanguineous marriages potentially play an important role in the transmission of β-thalassaemia in many communities. This study aimed to determine the rate and socio-demographic associations of consanguineous marriages and to assess the influence on the prevalence of β-thalassaemia in Sri Lanka. Three marriage registrars from each district of Sri Lanka were randomly selected to prospectively collect data on all couples who registered their marriage during a 6-month period starting 1st July 2009. Separately, the parents of patients with β-thalassaemia were interviewed to identify consanguinity. A total of 5255 marriages were recorded from 22 districts. The average age at marriage was 27.3 (±6.1) years for males and 24.1 (±5.7) years for females. A majority (71%) of marriages were ‘love’ marriages, except in the Moor community where 84% were ‘arranged’ marriages. Overall, the national consanguinity rate was 7.4%. It was significantly higher among ethnic Tamils (22.4%) compared with Sinhalese (3.8%) and Moors (3.2%) (p < 0.001). Consanguinity rates were also higher in ‘arranged’ as opposed to ‘love’ marriages (11.7% vs 5.6%, p < 0.001). In patients with β-thalassaemia, the overall consanguinity rate was 14.5%; it was highest among Tamils (44%) and lowest among Sinhalese (12%). Parental consanguinity among patients with β-thalassaemia was double the national average. Although consanguinity is not the major factor in the transmission of the disease in the country, emphasis should be given to this significant practice when conducting β-thalassaemia prevention and awareness campaigns, especially in high-prevalence communities.

Keywords

Sri LankaConsanguinityThalassaemia
Type
Research Article
Information
Journal of Biosocial Science , Volume 52 , Issue 4 , July 2020 , pp. 573 - 584
Copyright
© Cambridge University Press 2019

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