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The influence of early diet on later development

Published online by Cambridge University Press:  31 July 2008

Ruth Morley
Ruth Morley
Affiliation:
MRC Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH
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Summary

The possibility that early nutrition has long term consequences in man has been much debated. There have been limited opportunities to perform formal randomised studies on the effect of early nutrition in man and many studies have been flawed by problems with study design. Infants born preterm are a special group. At the start of this study in 1982 evidence on which to base choice of diet was inconsistent and related only to short term outcome, and diets available for such babies differed greatly in nutrient content. In this group it was both ethical and practical to conduct a formal, randomised trial of early diet and outcome and the results were clearly needed for management decisions.

A long term prospective outcome study was undertaken on 926 preterm infants randomly assigned to the diet received in the neonatal period. Surviving children have been followed at 9 months, 18 months and now 7½–8 years of age. The findings suggest that children fed a nutrient supplemented preterm formula perform better than those fed a standard formula milk, and also that human milk may contain factors which promote brain growth or development. Outcome data from the randomised trials show that a very brief period of dietary manipulation (on average for the first 4 weeks of life) influences later development.

Type
Session 2: Physical Factors
Information
Journal of Biosocial Science , Volume 28 , Special Issue 4: Proceedings of the Galton Institute Symposium on Biological and Social Aspects of Intelligence , October 1996 , pp. 481 - 487
Copyright
Copyright © Cambridge University Press 1996

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References

Barker, D. J. P., Gluckman, P. D., Godfrey, K. M., Harding, J. E., Owens, J. A. & Robinson, J. S. (1993) Review. Fetal nutrition and cardiovascular disease in adult life. Lancet, 341, 938–941.CrossRefGoogle ScholarPubMed
Birch, D. G., Birch, E. E, Hoffman, D. R. & Uauy, R. D. (1992) Retinal development in very low birthweight infants fed diets differing in omega-3 fatty acids. Invest. Ophthalmol. Vis. Sci. 33, 2365–2376.Google ScholarPubMed
Britton, J. R. & Kastin, A. J. (1991) Biologically active polypeptides in milk. Am. J. med. Sci. 301, 370–374.CrossRefGoogle ScholarPubMed
Carlson, S. E., Werkman, S. H., Peeples, J. M. & Wilson, W. M. (1994) Long chain fatty acids and early visual and cognitive development of preterm infants. Eur. J. din. Nutr. 48, Suppl. 2 S27–30.Google ScholarPubMed
Grantham-McGregor, S. (1987) Field Studies in Early Nutrition and Later Achievement, pp. 221–233. Academic Press, London.Google Scholar
Innis, S. M. (1991) Essential fatty acids in growth and development. Prog. Lipid Res. 30, 39–103.CrossRefGoogle ScholarPubMed
Janowsky, J. S., Scott, D. T., Wheeler, R. E. & Auestad, N. (1995) Fatty acids affect early language development. Pediatr. Res. 37, 310A.Google Scholar
Lewis, D. S., Mott, G. E., McMahan, C. A., Mason, E. J., Carey, K. D. & McGill, H. C. (1988) Deferred effects of preweaning diet on atherosclerosis in adolescent baboons. Atherosclerosis, 8, 274–280.Google ScholarPubMed
Lucas, A. (1991) Programming by early nutrition in man. In: The Childhood Environment and Adult Disease, pp. 38–55. CIBA Foundation Symposium 156. Edited by Bock, G. R. & Whelan., J.Wiley, Chichester.Google Scholar
Lucas, A., Cole, T. J., Morley, R., Lucas, P. J., Davis, J. A., Bamford, M. F., Crowle, P., Dossetor, J. F. B., Pearse, R. & Boon, A. J. (1988) Factors associated with a mother's choice to provide breast milk for a preterm infant. Arch. Dis. Child. 63, 48–52.CrossRefGoogle Scholar
Lucas, A., Morley, R., Cole, T. J. & Gore, S. M. (1994) A randomised multicentre study of human milk versus formula and later development in preterm infants. Arch. Dis. Child. 70, F141–F146.CrossRefGoogle ScholarPubMed
Lucas, A., Morley, R., Cole, T. J., Gore, S. M., Davis, J. A., Bamford, M. F. M. & Dossetor, J. F. B. (1989) Early diet in preterm babies and developmental status in infancy. Arch. Dis. Child. 11, 1570–1578.CrossRefGoogle Scholar
Lucas, A., Morley, R., Cole, T. J., Gore, S. M., Lucas, P. J., Crowle, P., Pearse, R., Boon, A. J. & Powell, R. (1990) Early diet in preterm babies and developmental status at 18 months. Lancet, 335, 1477–1481.CrossRefGoogle ScholarPubMed
Lucas, A., Morley, R., Cole, T. J., Lister, G. & Leeson Payne, C. (1991) Breast milk and subsequent intelligence quotient in children born preterm. Lancet, 339, 261–264.CrossRefGoogle Scholar
Makrides, M., Neumann, M. A., Simmer, K., Pater, J. & Gibson, R. (1995) Are long chain polyunsaturated fatty acids essential nutrients in infancy? Lancet, 345, 1463–1468.CrossRefGoogle ScholarPubMed
Morley, R., Cole, T. J., Powell, R. & Lucas, A. (1988) Mother's choice to provide breast milk and developmental outcome. Arch. Dis. Child. 63, 1382–1385.CrossRefGoogle ScholarPubMed
Smart, J. (1986) Undernutrition, learning and memory: review of experimental studies. In: Proceedings of XIII International Congress of Nutrition, pp. 74–78. Edited by Taylor, T. G. & Jenkins., N. K.Libbey, London.Google Scholar