Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-29T19:02:56.618Z Has data issue: false hasContentIssue false
  • English
  • Français

The contribution of genetic disease to paediatric mortality in a university hospital in bogota

Published online by Cambridge University Press:  31 July 2008

J. E. Bernal ,
G. Ortega  and
A. Umana
J. E. Bernal
Affiliation:
Clinical Genetics Unit, Hospital San Ignacio, Universidad Javeriana, Bogota, Colombia
G. Ortega
Affiliation:
Department of Pathology, Hospital San Ignacio, Universidad Javeriana, Bogota, Colombia
A. Umana
Affiliation:
Clinical Genetics Unit, Hospital San Ignacio, Universidad Javeriana, Bogota, Colombia
Get access Rights & Permissions [Opens in a new window]

Summary

The records of 15 years of paediatric necropsies in the Department of Pathology of the Hospital San Ignacio in Bogota were reviewed and the results classified according to the various types of genetic pathology. It is shown that out of 1463 paediatric necropsies, 377 (25·8%) had either a congenital defect or a disease considered as genetic to some extent. Simple Mendelian diseases and chromosomal disorders account together for more than 5% of the total deaths. When the pathologies with a complex genetic contribution to the aetiology are also taken into account, the figure rises to more than 20%. Overall, the study shows that the burden of genetic pathology is also important in countries, like Colombia, where other causes of death have traditionally been the main concern of public health measures.

Type
Research Article
Information
Journal of Biosocial Science , Volume 15 , Issue 4 , October 1983 , pp. 465 - 471
Copyright
Copyright © Cambridge University Press 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Carter, C.O. (1956) Changing patterns in the causes of death at the Hospital for Sick Children. Gt Ormond Str. J. 11, 65.Google Scholar
Day, N. & Holmes, L.B. (1973) The incidence of genetic disease in a university hospital population. Am. J. hum. Genet. 12, 237.Google Scholar
Kennedy, W.P. (1967) Epidemiologic aspects of the problem of congenital malformations and birth defects, Orig. Artic. Ser. 3, 1.Google Scholar
McKusick, V.A. (1978) Mendelian Inheritance in Man, 5th edn.The Johns Hopkins University Press, Baltimore.Google Scholar
Polani, P.E. (1973) The incidence of development and other genetic abnormalities. Guy's Hosp. Rep. 122, 53.Google Scholar
Puffer, R.R. & Serrano, C.V. (1973) Patterns of Mortality in Childhood. Scientific Publication No. 262, Pan American Health Organization, Regional Office of WHO, Washington, DC.Google Scholar
Roberts, D.F., Chavez, J. & Court, S.D.M. (1970) The genetic component in child mortality. Archs Dis. Childh. 45, 33.CrossRefGoogle ScholarPubMed
Roberts, C.J. & Powell, R.G. (1975) Interrelation of the common congenital malformations. Some aetiological implications. Lancet, ii, 848.CrossRefGoogle Scholar