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Effects of low dietary aflatoxin B1 on broiler liver concentration without and with Mycosorb® toxin binder

Published online by Cambridge University Press:  05 December 2013

C.A. Moran ,
J. Apajalahti ,
A. Yiannikouris ,
S. Ojanperä  and
H. Kettunen
C.A. Moran*
Affiliation:
Alltech France, 25 rue Greffulhe, 92300 Levallois-Perret, France
J. Apajalahti
Affiliation:
Alimetrics Ltd., Koskelontie 19 B, 02920 Espoo, Finland
A. Yiannikouris
Affiliation:
Alltech Inc, 3031 Catnip Hill Pike, Nicholasville, 40356 KY, USA
S. Ojanperä
Affiliation:
Alimetrics Ltd., Koskelontie 19 B, 02920 Espoo, Finland
H. Kettunen
Affiliation:
Alimetrics Ltd., Koskelontie 19 B, 02920 Espoo, Finland
*
*Corresponding author:[email protected]
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Summary

A pilot study was conducted to evaluate the suitability of hepatic aflatoxin (AFB1) concentration as a biomarker to assess the in vivo efficacy of a mycotoxin binder in poultry when AFB1 dietary concentrations are low. Diets containing low doses of AFB1 without or with Mycosorb® (MTB), a mycotoxin binder, were fed to broilers from 7 to 21 days of age. The accumulation of AFB1 in liver was measured by high performance liquid chromatography with a detection limit of 5 ng/kg liver. In response to 10 and 50 µg AFB1/kg feed, hepatic AFB1 accumulation was 27 and 145 ng AFB1/kg liver, respectively. At each dietary concentration of AFB1, the inclusion of 5 g MTB/kg of feed reduced (P < 0.1 for 10 μg AFB1/kg feed and P < 0.05 for 50 μg AFB1/kg feed) hepatic AFB1 accumulation by at least 50%. These results suggest that hepatic AFB1 concentration is a suitable biomarker for evaluating mycotoxin binder efficacy in poultry fed the EU maximum dietary concentration of 10 µg of AFB1/kg feed.

Keywords

Aflatoxin B1mycotoxinbroilerliverMycosorb®
Type
Pilot Study
Information
Journal of Applied Animal Nutrition , Volume 2 , 2013 , e4
Copyright
Copyright © Cambridge University Press and Journal of Applied Animal Nutrition Ltd. 2013 

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