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Pancreatic endocrine cells in Bufo bufo: immunocytochemistry and ultrastructure

Published online by Cambridge University Press:  01 February 1998

F. ACCORDI ,
M. A. BRACCI  and
F. VENTOLA
F. ACCORDI
Affiliation:
Dipartimento di Biologia Animale e dell'Uomo, Università ‘La Sapienza’, Rome, Italy
M. A. BRACCI
Affiliation:
Dipartimento di Biologia Animale e dell'Uomo, Università ‘La Sapienza’, Rome, Italy
F. VENTOLA
Affiliation:
Dipartimento di Biologia Animale e dell'Uomo, Università ‘La Sapienza’, Rome, Italy
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Abstract

The endocrine pancreas of the toad consists of rounded islets of various sizes embedded in the exocrine tissue. Isolated cells are also present. At least 4 types of endocrine cell are distinguishable by shape, size and electrondensity of the secretory granules as well as by their immunoreactivity with different antisera: insulin, somatostatin, pancreatic polypeptide, and glucagon cells. Insulin cells can be divided into 2 types according to their cytoplasmic electrondensity. Colocalisation of different hormones in the same cell is rarely observed. The close contact between endocrine and exocrine cells and the scarcity of nerve supply is indicative of a paracrine control of hormone secretion.

Keywords

Amphibiatoadinsulinsomatostatinglucagonpancreatic polypeptide
Type
Research Article
Information
The Journal of Anatomy , Volume 192 , Issue 2 , February 1998 , pp. 195 - 202
Copyright
© Anatomical Society of Great Britain and Ireland 1998

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