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Protein metabolism in lambs from lines divergently selected for weaning weight

Published online by Cambridge University Press:  27 March 2009

V. H. Oddy ,
P. A. Speck ,
H. M. Warren  and
P. C. Wynn
V. H. Oddy
Affiliation:
1NSW AgricultureElizabeth Macarthur Agricultural InstitutePMB 8Camden 2570 NSWAustralia
P. A. Speck
Affiliation:
2Department of Animal ScienceUniversity of New EnglandArmidale 2351 NSWAustralia
H. M. Warren
Affiliation:
1NSW AgricultureElizabeth Macarthur Agricultural InstitutePMB 8Camden 2570 NSWAustralia
P. C. Wynn
Affiliation:
3CSIRO Division of Animal ProductionLocked Bag 1Delivery CentreBlacktown 2148 NSWAustralia
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Summary

The physiological consequences of selection for weaning weight were investigated using 14-month-old castrated male Merino lambs from lines selected for (W +) and against (W – ) weight at weaning for over 10 generations. The selection experiment commenced in 1953 and was conducted at Trangie, NSW, Australia. Lambs from these lines now differ by 42% in weight at weaning and maturity, and have a proportionately similar composition of protein, fat and ash in their bodies at similar stages of maturity. In the whole body, there were no apparent between-strain differences in protein synthesis, but W + lambs had lower (P < 0·05) rates of phenylalanine oxidation than W – lambs. In hind limb muscle, protein metabolism of W + lambs was more responsive to food intake than in W – lambs. In particular, the rate of change of protein degradation differed (P < 0·05) between the lines in response to food intake per unit liveweight with protein degradation decreasing with increased feed intake in W + lambs. W + lambs had lower (P < 0·05) rates of blood flow to, and used less (P < 0·05) oxygen per kg hind limb muscle than W— lambs. Endocrine differences between the lines included increased (P < 0·05) plasma insulin-like growth factor-I (IGF-1) concentration in W + compared to W— lambs and, from regression analysis, an indication that there was a higher (P < 0·01) response in hind limb protein gain to insulin in the W + lambs.

These results suggest that selection for weaning weight has altered the dynamics of protein metabolism in lambs, principally through alterations in protein breakdown in muscle. Moreover, they suggest that there are associated genetic differences in endocrine control of protein metabolism which involve insulin and possibly IGF-I.

Type
Animals
Information
The Journal of Agricultural Science , Volume 124 , Issue 1 , February 1995 , pp. 129 - 137
Copyright
Copyright © Cambridge University Press 1995

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