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Physiological responses of farmed red deer to management practices and their modulation by long-acting neuroleptics

Published online by Cambridge University Press:  27 March 2009

S. Diverio ,
P. J. Goddard  and
I. J. Gordon
S. Diverio
Affiliation:
Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB9 2QJ, Scotland, UK
P. J. Goddard
Affiliation:
Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB9 2QJ, Scotland, UK
I. J. Gordon
Affiliation:
Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB9 2QJ, Scotland, UK
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Summary

Twelve red deer (Cervus elaphus) hinds from a research facility in Eastern Scotland were randomly divided into two groups between June and September to study the physiological response to three management practices, given sequentially, which were expected to cause increasing levels of stress (herding; herding and handling; and herding, handling and a veterinary procedure). One group of animals received a long-acting neuroleptic (LAN; perphenazine enanthate and zuclopenthixol acetate) on three occasions at 4-week intervals. Automatic blood sampling equipment (ABSE) was used to obtain blood samples remotely before, during and after the application of each of the stressors. The plasma concentrations of cortisol, creatine phosphokinase (CPK), aspartate aminotransferase (AST), total protein (TP), 3,5,3'-triiodothyronine (T3), thyroxine (T4) and testosterone (T) were measured and heart rates recorded. The ABSE provided a useful means of collecting blood samples without the superimposition of stress factors associated with conventional sampling. Increases in plasma concentrations of cortisol (P <0·01), CPK (P <0·01) and AST (P <0·05) were observed in all animals in response to all three management practices. There were smaller increases in plasma cortisol concentration (P <0·05) in those animals treated with LAN. The results suggested a degree of habituation of the hinds to some procedures common to all treatments, in agreement with previous analysis of the behavioual response of these animals. Peaks of heart rate were recorded over the 30-min period stressors were applied. Higher heart rates and T3 and T4 concentrations were observed in LAN-treated animals. Heart rates returned to baseline more rapidly in the LAN-treated animals. Higher plasma concentrations of testosterone were recorded in the first week of the study (P <0·001). Physiological and behavioural evidence supports the view that LANs are effective long-term tranquillizers in red deer.

Type
Animals
Information
The Journal of Agricultural Science , Volume 126 , Issue 2 , March 1996 , pp. 211 - 220
Copyright
Copyright © Cambridge University Press 1996

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References

REFERENCES

Armario, A. & Castellanos, J. M. (1984). Effect of acute and chronic stress on testosterone secretion in male rats. Journal of Endocrinological Investigation 7, 659–661.CrossRefGoogle ScholarPubMed
Baldock, N. M. & Sibly, R. M. (1990). Effects of handling and transportation on the heart rate and behaviour of sheep. Applied Animal Behaviour Science 28, 15–39.CrossRefGoogle Scholar
Barnett, J. L. & Hemsworth, P. H. (1990). The validity of physiological and behavioural measures of animal welfare. Applied Animal Behaviour Science 25, 177–187.CrossRefGoogle Scholar
Bartsch, R. C., McConnell, E. E., Imes, G. D. & Schmidt, J. M. (1977). A review of exertional rhabdomyolysis in wild and domestic animals and man. Veterinary Pathology 14, 314–324.CrossRefGoogle Scholar
Bassett, J. M. & Hinks, N. T. (1969). Micro-determination of corticosteroids in ovine peripheral plasma: effects of venipuncture, corticotrophin, insulin and glucose. Journal of Endocrinology 44, 387–403.CrossRefGoogle ScholarPubMed
Bubenik, G. A. (1982). Chemical immobilisation of captive white-tailed deer and the use of automatic blood samplers. In Chemical Immobilisation of North American Wildlife (Eds Nielsen, L., Haigh, J. C. & Fowler, M. E.), pp. 335–354. Milwaukee, Wisconsin: Wisconsin Humane Society.Google Scholar
Cannon, W. B. (1929). Bodily Changes in Pain, Hunger, Fear and Rage: an Account of Recent Researches into the Function of Emotional Excitement. New York, USA: Appleton.CrossRefGoogle Scholar
Diverio, S., Goddard, P. J., Gordon, I. J. & Elston, D. A. (1993). The effect of management practices on stress in farmed red deer (Cervus elaphus) and its modulation by long-acting neuroleptics: behavioural responses. Applied Animal Behaviour Science 36, 363–376.CrossRefGoogle Scholar
Ewbank, R. (1985). Behavioural responses to stress in farm animals. In Animal Stress (Ed. Moberg, G. P.), pp. 71–95. Bethesda, Maryland: American Physiological Society.CrossRefGoogle Scholar
Gandini, G. C., Ebedes, H. & Burroughs, R. E. J. (1989). The use of long acting neuroleptics in impala (Aepyceros ntelampus). Journal of the South African Veterinary Association 60, 206–207.Google Scholar
Goddard, P. J., Gordon, I. J. & Diverio, S. (1994). Remote blood sampling of red deer. In Proceedings of the 5th Symposium of the Federation of European Laboratory Animal Science Associations (Ed. Bunyan, J.), pp. 98–102. Brighton, UK.: Royal Society of Medicine Press.Google Scholar
Goodman, L. S. & Gilman, A. (1970). Drugs for psychoses. The phenothiazine derivatives. In The Pharmacological Basis of Therapeutics, 4th Edn (Eds Goodman, L. S. & Gilman, A.), pp. 155–169. London: The MacMillan Company, Collier-MacMillan Ltd.Google Scholar
Hargreaves, A. L. & Hutson, G. D. (1990 a). An evaluation of the contribution of isolation, up-ending and wool removal to the stress response to shearing. Applied Animal Behaviour Science 26, 103–113.CrossRefGoogle Scholar
Hargreaves, A. L. & Hutson, G. D. (1990 b). Changes in the heart rate, plasma cortisol and haematocrit of sheep during a shearing procedure. Applied Animal Behaviour Science 26, 91–101.CrossRefGoogle Scholar
Harlow, H. J., Thorne, E. T., Williams, E. S., Belden, E. L. & Gern, W. A. (1987). Adrenal responsiveness in domestic sheep (Ovis aries) to acute and chronic stressors as predicted by remote monitoring of cardiac frequency. Canadian Journal of Zoology 65, 2021–2027.CrossRefGoogle Scholar
Harthoorn, A. M. (1982). Physical aspects of both mechanical and chemical capture. In Chemical Immobilisation of North American Wildlife (Eds Nielsen, L., Haigh, J. C. & Fowler, M. E.), pp. 63–71. Milwaukee, Wisconsin: Wisconsin Humane Society.Google Scholar
Hesse, V., Vilser, C., Scheibe, J., Jahreis, G. & Foley, T. (1989). Thyroid hormone metabolism under extreme body exercise. Experimental Clinical Endocrinology 94, 82–88.CrossRefGoogle Scholar
International Federation of Clinical Chemistry (1978). International Federation of Clinical Chemistry Committee on Standard Enzyme Panel. Clinical Chemistry 24, 720–721.Google Scholar
Jago, J. G., Matthews, L. R., Hargreaves, A. L. & Van Ecken, F. (1993). Preslaughter handling of red deer: implications for welfare and carcass quality. In Proceedings of a Deer Course for Veterinarians: Deer Branch Course: No. 10, pp. 27–39. Deer Branch of the New Zealand Veterinary Association.Google Scholar
Kerr, M. G. (1989). Veterinary Laboratory Medicine, pp. 113–114. London: Blackwell Scientific Publications.Google Scholar
Kilgour, R. & De Langan, H. (1970). Stress in sheep resulting from management practices. In Proceedings of the New Zealand Society for Animal Production 30, 65–76.Google Scholar
Knox, C. M., Hattingh, J. & Raath, J. P. (1989). The effect of trilafon enanthate on boma stress in the impala, Aepyceros melampus (Lichtenstein). South African Journal of Science 85, 335.Google Scholar
Knox, D. P., McKelvey, W. A. C. & Jones, D. G. (1988). Blood biochemical reference values for farmed deer. Veterinary Record 122, 109–112.CrossRefGoogle Scholar
Lawes Agricultural Trust (1987). Genstat 5, Release 2.2 Reference Manual. Oxford: Clarendon Press.Google Scholar
MacArthur, R. A., Johnson, R. H. & Geist, V. (1979). Factors influencing heart rate in free-ranging bighorn sheep: a physiological approach to the study of wildlife harassment. Canadian Journal of Zoology 57, 2010–2021.CrossRefGoogle Scholar
MacArthur, R. A., Geist, V. & Johnson, R. H. (1982). Cardiac and behavioural responses of mountain sheep to human disturbance. Journal of Wildlife Management 46, 351–358.CrossRefGoogle Scholar
Matthews, L. R. & Cook, C. J. (1991). Deer welfare research. Ruakura findings. In Proceedings of a Deer Course for Veterinarians. Deer Branch Course No. 8, pp. 120–127. Deer Branch of the New Zealand Veterinary Association.Google Scholar
Mayes, R. W., Lamb, C. S. & Colgrove, P. M. (1984). The use of both C14 and C13 tracers to derive models of carbon flux through plasma glucose and blood CO2 pools in sheep. Canadian Journal of Animal Science 44, 122–123.CrossRefGoogle Scholar
Mayes, R. W., Lamb, C. S. & Colgrove, P. M. (1988). Equipment for estimating carbon dioxide turnover rate in undisturbed grazing sheep. In Proceedings of the Nutrition Society 47, 136a.Google Scholar
McCrindle, C. M. E., Ebedes, H. & Swan, G. E. (1989). The use of long-acting neuroleptics, perphenazine enanthate and pipothiazine palmitate in two horses. Journal of the South African Veterinary Association 60, 208–209.Google ScholarPubMed
Mitchell, G., Hattingh, J. & Ganhao, M. (1988). Stress in cattle assessed after handling, after transport and after slaughter. Veterinary Record 123, 201–205.CrossRefGoogle ScholarPubMed
Moberg, G. P. (1985). Biological response to stress: key to assessment of animal well-being. In Animal Stress (Ed. Moberg, G. P.), pp. 27–49. Bethesda, Maryland: American Physiological Society.CrossRefGoogle Scholar
Mutayoba, B. M. & Gombe, S. (1989). Effect of African trypanosomiasis on plasma cortisol and thyroxine concentration in goats. Research in Veterinary Science 47, 315–318.CrossRefGoogle ScholarPubMed
Orr, T. E. & Mann, D. R. (1990). Effects of restraint stress on plasma LH and testosterone concentrations, Leydig cell LH/HCG receptors, and in vitro testicular steroidogenesis in adult rats. Hormones and Behaviour 24, 324–341.CrossRefGoogle ScholarPubMed
Pearson, R. A. & Mellor, D. J. (1976). Some behavioural changes in pregnant goats and sheep during adaptation to laboratory conditions. Research in Veterinary Science 20, 215–217.CrossRefGoogle ScholarPubMed
Pollard, J. C., Suttie, J. M., Littlejohn, R. P., Laas, F. J. & Corson, I. D. (1991). Measurement of behaviour and heart rate to assess the aversiveness of handling treatments used for red deer. Proceedings of a Deer Course for Veterinarians. Deer Branch Course No. 8, pp. 109–119. Deer Branch of the New Zealand Veterinary Association.Google Scholar
Pollard, J. C., Littlejohn, R. P., Johnstone, P., Laas, F. J., Carson, I. D. & Suttie, J. M. (1992). Behaviour and heart rate responses to antler removal in red deer. New Zealand Veterinary Journal 40, 56–61.CrossRefGoogle ScholarPubMed
Robinson, D. L. (1987). Estimation and use of variance components. The Statistician 36, 3–14.CrossRefGoogle Scholar
Ruckebusch, Y., Phaneuf, L. P. & Dunlop, R. (1991). Hormones of the adrenal cortex and medulla. In Physiology of Small and Large Animals (Eds Ruckebusch, Y., Phaneuf, L. P. & Dunlop, R.), pp. 534–541. Ontario, Canada.Google Scholar
Seal, U. S., Ozoga, J. J., Erickson, A. W., & Verme, L. J. (1972). Effects of immobilization on blood analysis of white-tailed deer. Journal of Wildlife Management 36, 1034–1040.CrossRefGoogle Scholar
Shi, Z. D. & Barrell, G. K. (1992). Requirement of thyroid function for the expression of seasonal reproductive and related changes in red deer (Cervus elaphus) stags. Journal of Reproduction and Fertility 94, 251–259.CrossRefGoogle Scholar
Skeggs, L. T. & Hochstrasser, H. (1964). Multiple automatic sequential analyses. Clinical Chemistry 10, 918–936.CrossRefGoogle Scholar
Smidt, D. (1983). Advantages and problems of using integrated systems of indicators as compared to single traits. In Indicators Relevant to Farm Animal Welfare (Ed. Smidt, D.), pp. 201–207. Boston, USA: Martinus Nijhoff Publishers.CrossRefGoogle Scholar
Szazs, G., Gruber, W. & Bernt, E. (1976). Creatine kinase in serum: determination of optimum reaction conditions. Clinical Chemistry 22, 650–656.CrossRefGoogle Scholar
Thurley, D. C. & McNatty, K. P. (1973). Factors affecting peripheral cortisol levels in unrestricted ewes. Ada Endocrinologica 74, 331–337.Google ScholarPubMed
Walther, F. R. (1984). Excitement activities, alarm and flight signals. In Communication and Expression in Hoofed Mammals, pp. 116–129. Bloomington, Indiana: Indiana University Press.Google Scholar
Webster, A. J. F. (1983). Environmental stress and the physiology, performance and health of ruminants. Journal of Animal Science 57, 1584–1593.CrossRefGoogle ScholarPubMed
Zayan, R. & Dantzer, R. (1990). General introduction. Social stress: a new field of research in domestic animals. In Social Stress in Domestic Animals (Eds Zayan, R. & Dantzer, R.), pp. xi–xvii. Dordrecht, The Netherlands: Kluwer Academic Publishers.Google Scholar
Zlegler, M. G., Morrissey, E. C. & Marshall, L. F. (1990). Catecholamine and thyroid hormones in traumatic injury. Critical Care Medicine 18, 253–258.CrossRefGoogle Scholar