Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-22T18:51:10.106Z Has data issue: false hasContentIssue false

Parental imprinting effects on growth traits and Kleiber ratio in sheep

Published online by Cambridge University Press:  02 May 2022

F. Ghafouri-Kesbi*
Affiliation:
Department of Animal Science, Faculty of Agriculture, Bu-Ali Sina University, Hamedan, Iran
M. Mokhtari
Affiliation:
Department of Animal Science, Faculty of Agriculture, University of Jiroft, P.O. Box 364, Jiroft, Iran
M. Gholizadeh
Affiliation:
Department of Animal Science, Faculty of Animal and Aquatic Science, Sari Agricultural Sciences and Natural Resources University, Sari, Iran
M. Amiri Roudbar
Affiliation:
Department of Animal Science, Safiabad-Dezful Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education & Extension Organization (AREEO), Dezful, 333, Iran
M. A. Abbasi
Affiliation:
Animal Science Research Institute of Iran (ASRI), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
*
Author for correspondence: F. Ghafouri-Kesbi, E-mail: [email protected]; [email protected]

Abstract

The goal was to study imprinting effects on birth weight (BW), weaning weight (WW), six months weight (W6), pre- and post-weaning growth rate (GRa and GRb), and pre- and post-weaning Kleiber ratio (KRa and KRb) in Baluchi and Makuie sheep breeds. Analyses were done in a two steps process. In the first step, each trait was analysed with a series of 12 univariate animal models, including different combinations of direct and maternal effects and the best model was selected by the AIC criterion. In the second step, three new models were fitted by adding either maternal imprinting effect, paternal imprinting effect, or both of them, respectively, to the best model already selected in the first step, and changes in AIC were monitored. (Co)variances between traits were estimated using bivariate analyses. In Baluchi sheep, for BW, WW and W6, estimates of maternal imprinting heritability (${\boldsymbol h}_{{\boldsymbol mi}}^2$) were 0.12 ± 0.02, 0.08 ± 0.01 and 0.09 ± 0.01, respectively. In Makuie sheep, paternal imprinting heritability (${\boldsymbol h}_{{\boldsymbol pi}}^2$) for BW, WW, W6, GRb and KRb were 0.17 ± 0.05, 0.8 ± 0.05, 0.38 ± 0.10, 0.71 ± 0.15 and 0.65 ± 0.13, respectively. In Baluchi sheep, strong maternal imprinting correlations were observed between BW and WW (0.93 ± 0.05), BW and W6 (0.80 ± 0.07) and WW and W6 (0.91 ± 0.02). In Makuie sheep, paternal imprinting correlations ranged from −0.97 ± 0.33 (BW-GRb) to 0.99 ± 0.47 (GRb-KRb). It was concluded that imprinting effects need to be included in the statistical model to increase the accuracy of genetic evaluation. However, to have accurate and reliable estimates of imprinting effects, the availability of large data sets and deep pedigrees are necessary.

Type
Animal Research Paper
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abbasi, MA and Ghafouri-Kesbi, F (2011) Genetic (co)variance components for body weight and body measurements in Makooei sheep. Asian-Australian Journal of Animal Science 24, 739743.CrossRefGoogle Scholar
Akaike, H (1974) A new look at the statistical model identification. IEEE Transactions on Automatic Control 19, 716723.CrossRefGoogle Scholar
Amiri Roudbar, M, Mohammadabadi, M, Mehrgardi, AA and Abdollahi-Arpanahi, R (2017) Estimates of variance components due to parent-of-origin effects for body weight in Iran-Black sheep. Small Ruminant Research 149, 15.CrossRefGoogle Scholar
Amiri Roudbar, M, Abdollahi-Arpanahi, R, Ayatollahi Mehrgardi, A, Mohammadabadi, M, Taheri Yeganeh, A and Rosa, GJM (2018) Estimation of the variance due to parent-of-origin effects for productive and reproductive traits in Lori-Bakhtiari sheep. Small Ruminant Research 160, 95102.CrossRefGoogle Scholar
Bahreini-Behzadi, MR, Aslaminejad, AA, Sharifi, AR and Simianer, H (2014) Comparison of mathematical models for describing the growth of Baluchi sheep. Journal of Agricultural Science and Technology 14, 5768.Google Scholar
Bijma, P and Bastiaansen, JWM (2014) Standard error of the genetic correlation: how much data do we need to estimate a purebred-crossbred genetic correlation? Genetic Selection Evolution 46, 79.CrossRefGoogle ScholarPubMed
Davis, GH, Dodds, KG, Wheeler, R and Jay, NP (2001) Evidence that an imprinted gene on the X chromosome increases ovulation rate in sheep. Biology of Reproduction 64, 216221.CrossRefGoogle ScholarPubMed
de Vries, AG, Kerr, R, Tier, B, Long, T and Meuwissen, THE (1994) Gametic imprinting effects on rate and composition of pig growth. Theoretical and Applied Genetics 88, 10371042.CrossRefGoogle ScholarPubMed
Essl, A and Voith, K (2002) Estimation of variance components due to imprinting effects with DFREML and VCE: results of a simulation study. Journal of Animal Breeding and Genetics 119, 114.CrossRefGoogle Scholar
Falconer, DS and Mackay, TF (1996) Introduction to Quantitative Genetics, 4th Edn. Harlow, Essex, UK: Longmans Green.Google Scholar
Ferguson-Smith, A (2011) Genomic imprinting: the emergence of an epigenetic paradigm. Nature Reviews Genetics 12, 565575.CrossRefGoogle ScholarPubMed
Gerstmayr, S (1991) Impact of the data structure on the reliability of the estimated genetic parameters in an animal model with maternal effects. Journal of Animal Breeding and Genetics 109, 321336.CrossRefGoogle Scholar
Hager, R, Cheverud, JM and Wolf, JB (2008) Maternal effects as the cause of parent-of-origin effects that mimic genomic imprinting. Genetics 178, 17551762.CrossRefGoogle ScholarPubMed
Jeon, JT, Carlborg, O, Tornsten, A, Giuffra, E, Amarger, V, Chardon, P, Andersson-Eklund, L, Andersson, K, Hansson, I, Lundstrom, K and Andersson, L (1999) A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nature Genetics 21, 157158.CrossRefGoogle Scholar
Karami, K, Zerehdaran, S, Javadmanesh, A and Shariati, MM (2019) Assessment of maternal and parent of origin effects in genetic variation of economic traits in Iranian native fowl. British Poultry Science 60, 486492.CrossRefGoogle ScholarPubMed
Kleiber, M (1947) Body size and metabolic rate. Physiology Review 27, 511541.CrossRefGoogle ScholarPubMed
Meyer, K (1992) Bias and sampling (co)variances of estimates of variance components due to maternal effects. Genetic Selection Evolution 24, 487509.CrossRefGoogle Scholar
Meyer, K (2020) WOMBAT: a tool for estimation of genetic parameters – highlights and updates. 6th International Conference on Quantitative Genetics, Brisbane, Queensland, Australia, 3–13 November, 1, 84.Google Scholar
Meyer, K and Tier, B (2012) Estimates of variances due to parent of origin effects for weights of Australian beef cattle. Animal Production Science 52, 215224.CrossRefGoogle Scholar
Neugebauer, N, Luther, H and Reinsch, N (2010) Parent-of-origin effects cause genetic variation in pig performance traits. Animal: An International Journal of Animal Bioscience 4, 672681.CrossRefGoogle ScholarPubMed
O'Doherty, AM, MacHugh, DE, Spillane, C and Magee, DA (2015) Genomic imprinting effects on complex traits in domesticated animal species. Frontiers in Genetics 6, 156.Google ScholarPubMed
Rahman, A, Rehman, S, Akhtar, A, Jan, I, Qureshi, MS and Rahman, S (2013) Determination of meat yield and dressing percentage of Turki, Afghan Arabi and Baluchi sheep breeds in Afghanistan. Sarhad Journal of Agriculture 29, 113117.Google Scholar
Saedi, A (2016) Introducing Baluchi sheep breed. Available at https://www.makidam.ir/fa/news/1264.Google Scholar
Smit, MK, Segers, LG, Carrascosa, T, Shay, F, Baraldi, G, Gyapay, G, Snowder, M, Georges, N, Cockett, N and Charlier, C (2003) Mosaicism of solid gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype. Genetics 163, 453456.CrossRefGoogle ScholarPubMed
Spencer, H (2002) The correlation between relatives on the supposition of genomic imprinting. Genetics 161, 411417.CrossRefGoogle ScholarPubMed
Statistical Analysis System (SAS) (2004) SAS Users’ Guide, Version 9.1. Cary, NC, USA: SAS Institute Inc.Google Scholar
Tellam, RL, Cockett, NE, Vuocolo, T and Bidwell, CA (2012) Genes contributing to genetic variation of muscling in sheep. Frontiers in Genetics 3, 164.CrossRefGoogle ScholarPubMed
Tier, B and Meyer, K (2012) Analysing quantitative parent-of-origin effects with examples from ultrasonic measures of body composition In Australian beef cattle. Journal of Animal Breeding and Genetics 129, 359368.CrossRefGoogle ScholarPubMed