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Effects of a severe nutritional check in early post-natal life on the subsequent growth of sheep to the age of 12–14 months

Changes in body weight, wool and skeletal growth, and effects at the cellular level

Published online by Cambridge University Press:  27 March 2009

D. L. Hopkins  and
N. M. Tulloh
D. L. Hopkins
Affiliation:
School of Agriculture and Forestry, University of Melbourne, Parkville, 3052, Australia
N. M. Tulloh
Affiliation:
School of Agriculture and Forestry, University of Melbourne, Parkville, 3052, Australia
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Summary

The growth of 26 castrated ram lambs was severely restricted for the first 5 weeks of post-natal life. Subsequently, these lambs (group R) were fed ad libitum on the same high quality diets as fed to a control group of 26 similar lambs (group C) from birth.

At regular intervals lambs were weighed, X-rayed and surface measurements were aken. At the age of 12–14 months, covering the body-weight range of 63–83 kg, ten animals from each group were slaughtered for dissection and measurement. These data were used to compare the skeletal growth of the two groups of animals. Measurements of skeletal dimensions by dissection were compared with measurements obtained by surface and radiographic techniques. After slaughter, the brain, kidneys, liver, the left semitendinosus and gastrocnemius muscles from each lamb were used for the following analyses: dry matter, ash, fat, protein, DNA and RNA contents.

At the end of the period of feed restriction, there was a mean body-weight difference between groups of 9·2 kg (63%).This represented a weight for age difference of 36 days, which was reduced to 29 days at the conclusion of the experiment, restricted animals not having fully recovered from the period of underfeeding.

Clean wool production per day was significantly (P < 0·05) depressed by the restricted feeding, lambs in group C producing 11·07 g/day during the first shearing interval compared with 10·07 g/day from group R lambs. There was no difference between groups in clean wool produced during the second shearing interval.

Restricted feeding caused a reduction in the rate of bone growth but, during subsequent regrowth (apart from minor exceptions), it did not disrupt the relationship of skeletal dimensions to fleece-free body weight (FFBW). Surface measurements showed that during recovery, group R animals were significantly narrower (P < 0·05) at the hips and wider (P < 0·05) at the shoulders than group C animals. The results obtained from the radiographs for length of foreleg were similar to those obtained from surface measurements. Metacarpal width (measured at two sites) and weight were significantly greater in group R than in group C animals. With the exception of width at hips and although not statistically significant (P > 0·05), the skeletal measurements of group R were slightly greater than those of group C animals. This may have been due to the slightly greater age of group R at slaughter and to an effect of restricted feeding.

There was no significant difference between groups R and C in the DNA content of the tissues investigated. Neither was there any difference between the groups in cell size as indicated by the protein: DNA and tissue weight: DNA ratios. Even though hyperplasia and hypertrophy were slowed by the period of restricted feeding, this effect was transient, full recovery apparently occurring as indicated by tissue weights and composition at the time of slaughter. The RNA and the protein contents of the tissues were similar in both groups. In addition, the similarity of the RNA:DNA ratios suggests that tissues in each group possessed the same capacity to synthesize protein.

In practical terms, the recovery of group R was associated with a time lag in reaching any particular body weight and a loss of wool production. Both of these consequences are of economic importance. At the time the experiment ended, no skeletal stunting was evident in these sheep and, apparently, they had recovered in terms of cellular growth.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 105 , Issue 3 , December 1985 , pp. 551 - 562
Copyright
Copyright © Cambridge University Press 1985

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References

REFERENCES

Agricultural Research Council (1980). The Nutrient Requirements of Ruminant Livestock. Technical Review by an Agricultural Research Council Working Party. 2nd edn.Farnham Royal: Commonwealth Agricultural Bureaux.Google Scholar
Allden, W. G. (1968 a). Undernutrition of the Merino sheep and its sequelae. I. The growth and development of lambs following prolonged periods of nutritional stress. Australian Journal of Agricultural Research 19, 621–638.CrossRefGoogle Scholar
Allden, W. G. (1968 b). Undernutrition of the Merino sheep and its sequelae. III. The effect on life-time productivity of growth restrictions imposed at two stages of early post-natal life in a Mediterranean environment. Australian Journal of Agricultural Research 19, 981–996.CrossRefGoogle Scholar
Allden, W. G. (1968 c). Undernutrition of the Merino sheep and its sequelae. IV. Herbage consumption and utilization of feed for wool production following growth restrictions imposed at two stages of early post-natal life in a Mediterranean environment. Australian Journal of Agricultural Research 19, 997–1007.CrossRefGoogle Scholar
Allden, W. G. (1979). Undernutrition of the Merino sheep and its sequelae. V. The influence of severe growth restriction during early post-natal life on reproduction and growth in later life. Australian Journal of Agricultural Research 30, 939–948.CrossRefGoogle Scholar
Bertrand, H. A., Masaro, E. J. & Yu, B. D. (1977). Post-weaning food restriction reduces adipose cellularity. Nature 266, 62–63.CrossRefGoogle ScholarPubMed
Black, J. L. (1983). Growth and development of lambs. In Sheep Production (ed. Haresign, W.), pp. 21–58. London: Butterworth.Google Scholar
Campbell, R. G. & Dunkin, A. C. (1983). The influence of nutrition in early life on growth and development of the pig. 2. Effects of rearing method and feeding level on growth and development to 75 kg. Animal Production 36, 425–434.Google Scholar
Coop, I. E. & Clark, V. R. (1955). The influence of method of rearing as hoggets on the lifetime productivity of sheep. New Zealand Journal of Science and Technology 37 A, 214–228.Google Scholar
Dickerson, J. W. T. & NcAnulty, P. A. (1975). The response of hind-limb muscles of the weanling rat to undernutrition and subsequent rehabilitation. British Journal of Nutrition 33, 171–180.CrossRefGoogle ScholarPubMed
Dickerson, J. W. T. & Widdowson, E. M. (1960). Some effects of accelerating growth. II. Skeletal development. Proceeding of the Royal Society of London 152 B, 207–217.Google ScholarPubMed
Enesco, M. & Leblond, C. P. (1962). Increase in cell number as a factor in the growth of the organs and tissues of the young male rat. Journal of Embryology and Experimental Morphology 10, 530–562.Google Scholar
Enesco, M. & Puddy, D. (1964). Increase in the number of nuclei and weight in skeletal muscle of rats at various ages. American Journal of Anatomy 114, 225–244.CrossRefGoogle ScholarPubMed
Florini, J. R. & Breuer, C. B. (1967). Control of RNA and protein synthesis in normal muscle. In Exploratory Concepts in Muscular Dystrophy and Related Disorders (ed. Milhorat, A. T.), pp. 74–80. New York: Excerpta Medica Foundation.Google Scholar
Gaili, E. S. E.(1981). Anote on the effect offeed restriction in early post-natal life and subsequent rehabilitation on periosteal bone growth. Acta Veterinaria Yugoslavia 31 (5/6), 237–241.Google Scholar
Gunn, R. G. (1964). Levels of first winter feeding in relation to performance of Cheviot hill ewes. II. Body growth and development during the summer after treatment, 12–18 months. Journal of Agricultural Science, Cambridge 62, 123–149.CrossRefGoogle Scholar
Gunn, R. G. (1967). Levels of first winter feeding in relation to performance of Cheviot hill ewes. IV. Body growth and development from 18 months to maturity. Journal of Agricultural Science, Cambridge 69, 341–344.CrossRefGoogle Scholar
Hammond, J. (1932). Growth and Development of Mutton Qualities in the Sheep, p. 152. London: Oliver and Boyd.Google Scholar
Holmes, W. (1973). Size of animal in relation to productivity nutritional aspects. Proceedings of the British Society of Animal Production 2, 27–34.Google Scholar
Hopkins, D. L. (1984). The effect of undernutrition during early post-natal life on subsequent skeletal and cellular development in sheep. M.Agr.Sc. thesis, University of Melbourne.Google Scholar
Howarth, R. E. & Baldwin, R. L. (1971). Synthesis and accumulation of protein and nucleic acid in rat gastrocnemius muscle during normal growth, restricted growth and recovery from restricted growth. Journal of Nutrition 101, 477–484.CrossRefGoogle ScholarPubMed
Jackson, C. M. & Stewart, C. A. (1920). The effects of inanition in the young upon the ultimate size of the body and various organs in the albino rat. Journal of Experimental Zoology 30, 97–128.CrossRefGoogle Scholar
Johns, J. T. & Bergen, W. G. (1976). Growth in sheep: pre-and post-weaning hormone changes and muscle and liver development. Journal of Animal Science 43, 192–200.CrossRefGoogle ScholarPubMed
Kirton, A. H. (1970). Effect of pre-weaning plane of nutrition on subsequent growth and carcass quality of lambs. Proceedings of the New Zealand Society of Animal Production 30, 106–115.Google Scholar
McAnulty, P. A. & Dickerson, J. W. T. (1974). The development of the weanling rat during nutritionally induced growth retardation and during rehabilitation. British Journal of Nutrition 32, 301–312.CrossRefGoogle ScholarPubMed
Martin, R. F. & Hodgson, G. S. (1973). Estimation of DNA, RNA and 125I- and 3H-labelled DNA in the same sample. Analytical Biochemistry 52, 462–469.CrossRefGoogle Scholar
Masters, J. C. (1963). Nucleic acids and protein stores in the Merino sheep. Australian Journal of Biological Science 16, 192–200.CrossRefGoogle Scholar
Millward, D. J., Garlick, P. J., James, W. P. T., Nnanyelugs, D. O. & Ryatt, J. S. (1973). Relationship between protein synthesis and RNA content in skeletal muscle. Nature 241, 204–205.CrossRefGoogle ScholarPubMed
Norton, B. W. & Walker, D. M. (1970). Changes in nitrogen and nucleic acid contents of the liver and muscle of pre-ruminant lambs given high and low protein diets. Australian Journal of Agricultural Research 21, 641–647.CrossRefGoogle Scholar
Norton, B. W. & Walker, D. M. (1971). Nitrogen balance studies with the milk-fed lamb. 7. Effect of age of the lamb. British Journal of Nutrition 26, 1–6.CrossRefGoogle ScholarPubMed
Pálsson, J. & Vergés, J. B. (1952). Effects of the plane of nutrition on growth and the development of carcass quality in lambs. Journal of Agricultural Science, Cambridge 42, 1–149.CrossRefGoogle Scholar
Powell, S. E. & Aberle, E. D. (1975). Cellular growth of skeletal muscle in swine differing in muscularity. Journal of Animal Science 40, 476–485.CrossRefGoogle Scholar
Prud'hon, M., Benevent, M., Vezinhet, A. & Dulor, J. P. (1978). Croissance relative du squelette chez l'agneau. Influence du sexe et de la race. Annales de Biologie Animale Biochimie Biophysique 18, 5–9.CrossRefGoogle Scholar
Reardon, T. F. & Lambourne, L. J. (1966). Early nutrition and life-time reproductive performance of ewes. Proceedings of the Australian Society of Animal Production 6, 106–108.Google Scholar
Sands, J., Dobbing, J. & Gratrix, C. A. (1979). Cell number and cell size: organ growth and development and the control of catch-up growth in rats. Lancet, no. 8141, 503–505.CrossRefGoogle Scholar
Sarkar, N. K., Lodge, G. A. & Friend, D. W. (1977). Hyperplasic and hypertrophic growth in organs and tissues of the neonatal pig. Journal of Animal Science 45, 722–728.CrossRefGoogle ScholarPubMed
Schinkel, P. G. & Short, B. F. (1960). The influence of nutrition during early life on adult productivity in a group of Merino sheep. Proceedings of the Australian Society of Animal Production 3, 147—152.Google Scholar
Schinkel, P. G. & Short, B. F. (1961). The influence of nutritional level during pre-natal and early postnatal life on adult fleece and body characters. Australian Journal of Agricultural Research 12, 176–202.CrossRefGoogle Scholar
Trenkle, A., DeWitt, D. L. & Topel, D. (1978). Influence of age, nutrition and genotype on carcass traits and cellular development of M. longissimus of cattle. Journal of Animal Science 46, 1597–1603.CrossRefGoogle Scholar
Turner, H. N., Hayman, R. H., Riches, J. H., Roberts, N. F. & Wilson, L. T. (1953). Report No. 4. C.S.I.R.O. Australia. Division of Animal Health and Production.Google Scholar
Williams, I. H. (1976). Nutrition of the young pig in relation to body composition. Ph.D. thesis, University of Melbourne.Google Scholar
Williams, J. P. G., Tanner, J. M. & Hughes, P. C. R. (1974 a). Catch-up growth in male rats after growth retardation during the suckling period. Pediatric Research 8, 149–156.CrossRefGoogle ScholarPubMed
Williams, J. P. G., Tanner, J. M. & Hughes, P. C. R. (1974 b). Catch-up growth in female rats after growth retardation during the suckling period. Pediatric Research 8, 157–162.CrossRefGoogle ScholarPubMed
Winick, M. & Noble, A. (1965). Quantitative changes in DNA, RNA, and protein during prenatal and postnatal growth in the rat. Developmental Biology 12, 451–466.CrossRefGoogle ScholarPubMed
Winick, M. & Noble, A. (1966). Cellular response in rats during malnutrition at various ages. Journal of Nutrition 89, 300–306.CrossRefGoogle ScholarPubMed