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The effect of dietary addition of a polysaccharide from Atractylodes macrophala Koidz on growth performance, immunoglobulin concentration and IL-1β expression in weaned piglets

Published online by Cambridge University Press:  29 July 2009

L. L. LI ,
X. WU ,
H. Z. PENG ,
M. Z. FAN ,
Z. P. HOU ,
X. F. KONG ,
Y. L. YIN ,
B. ZHANG ,
T. J. LI  and
Y. Q. HOU
...Show all authors
L. L. LI
Affiliation:
Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan410125, China
X. WU
Affiliation:
Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan410125, China
H. Z. PENG
Affiliation:
College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan410128, China
M. Z. FAN
Affiliation:
Department of Animal and Poultry Science, University of Guelph, Guelph, OntarioN1 G 2W15, Canada
Z. P. HOU
Affiliation:
Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan410125, China
X. F. KONG
Affiliation:
Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan410125, China
Y. L. YIN*
Affiliation:
Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan410125, China
B. ZHANG
Affiliation:
College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan410128, China
T. J. LI
Affiliation:
Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan410125, China
Y. Q. HOU
Affiliation:
Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, Hubei430023, China
K. M. YANG
Affiliation:
Hunan Zhenghong Science and Technology Company, Changsha, Hunan410001, China
A. K. LI
Affiliation:
Academy of State Administration of Grain, Beijing100037, China
C. Y. LIU
Affiliation:
Changsha Vocational and Technical College, Changsha, Hunan410300, China
X. M. QIU
Affiliation:
Medical College of Hunan Normal University, Changsha, Hunan410008, China
Y. L. LIU
Affiliation:
Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, Hubei430023, China
*
*To whom all correspondence should be addressed. Email: [email protected]
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Summary

The present study was conducted to determine the effects of a polysaccharide of Atractylodes macrophala Koidz (PAM) as a dietary additive on growth performance, immunoglobulin concentration and IL-1β expression in weaned piglets. One hundred and twenty Landrace×Yorkshire piglets weaned at 28 days old (body weight 7·5±0·07 kg) were assigned to five treatment groups (three pens/group, eight piglets/pen) fed maize/soybean-based diets supplemented with 0, 3, 6 or 9 g of PAM/kg diet or antibiotics (0·4 g flavomycin/kg+0·13 g olaquindox/kg). The experimental period was 28 days. With increasing PAM supplementation levels, average daily gain was greater (quadratic, P<0·05) and the ratio of amount fed to live weight (LW) gain (feed/gain) improved (quadratic, P<0·05) during days 14–28 and overall, and diarrhoea incidence decreased (linear, P<0·05) during days 14–28. Supplementation of PAM also increased (quadratic, P<0·05) serum concentrations of interleukin (IL)-2 and IL-6 on day 14, and increased (quadratic, P<0·05) IL-1β expression in jejunal mucosa and lymph nodes. Concentrations of PAM between 6 and 9 g/kg presented the strongest bioactivity compared to the control group or antibiotic-fed group. These findings indicate that PAM is effective in improving growth performance and cytokine response, which suggests that PAM can be used as a diet additive for weanling piglets.

Type
Animals
Information
The Journal of Agricultural Science , Volume 147 , Issue 5 , October 2009 , pp. 625 - 631
Copyright
Copyright © Cambridge University Press 2009

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