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Concentrations of intermediate metabolites in the blood and hepatic tissues of pregnant and non-pregnant ewes

Published online by Cambridge University Press:  27 March 2009

I. D. Herriman ,
R. J. Heitzman ,
I. Priestley  and
G. S. Sandhu
I. D. Herriman
Affiliation:
Department of Functional Pathology, Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 0NN
R. J. Heitzman
Affiliation:
Department of Functional Pathology, Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 0NN
I. Priestley
Affiliation:
Department of Functional Pathology, Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 0NN
G. S. Sandhu
Affiliation:
Department of Functional Pathology, Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 0NN
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Summary

Six late pregnant and six non-pregnant Finnish Landrace × Dorset Horn ewes were fed a standard diet. Blood and liver samples were taken and the concentrations of the following metabolites measured: adenine monophosphate (AMP), adenine diphosphate (ADP), adenine triphosphate (ATP), citrate, 2-oxoglutarate, phosphoenol-pyruvate, pyruvate, lactate, 2·phosphoglycerate, 3·phosphoglycerate, malate, β·hydroxybutyrate, acetoacetate, glutamate, alanine, NAD+ and NADH. Comparing non-pregnant with pregnant ewes the liver of the pregnant animals had reduced concentrations of lactate, ADP, NAD+ and NADH, and in the blood there were reductions in lactate, pyruvate, lactate/pyruvate ratio and urea. The concentrations of the other metabolites of the pregnant ewes receiving adequate nutrition were little changed from those of the non-pregnant ewes. The significance of these findings is discussed.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 87 , Issue 2 , October 1976 , pp. 407 - 411
Copyright
Copyright © Cambridge University Press 1976

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