Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-04T21:37:25.706Z Has data issue: false hasContentIssue false
  • English
  • Français

Butyric acid as a promising alternative to antibiotic growth promoters in broiler chicken production

Published online by Cambridge University Press:  10 April 2019

M. Raza ,
A. Biswas ,
N. A. Mir Open the ORCID record for N. A. Mir [Opens in a new window]  and
A. B. Mandal
M. Raza
Affiliation:
ICAR-Central Avian Research Institute, Izatnagar, Bareilly, U.P., 243122, India
A. Biswas
Affiliation:
ICAR-Central Avian Research Institute, Izatnagar, Bareilly, U.P., 243122, India
N. A. Mir*
Affiliation:
ICAR-Central Avian Research Institute, Izatnagar, Bareilly, U.P., 243122, India
A. B. Mandal
Affiliation:
ICAR-Central Avian Research Institute, Izatnagar, Bareilly, U.P., 243122, India
*
Author for correspondence: N. A. Mir, E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The current work studied the effects of butyric acid (BA) supplementation on the growth performance, carcase characteristics, immunity, gut histology and serum biochemistry of broiler chicken. Four experimental diets were formulated: control, 20 mg bacitracin methylene di-salicylate/kg diet (BMD-supplemented), 3 g BA/kg diet and 4 g BA/kg diet. The results revealed higher body weight gain (BWG) in BA and BMD-supplemented groups. Only BMD supplementation increased the feed intake (FI) of birds, whereas BA supplementation improved feed efficiency. Expression of glucose transporter (GLUT5), sodium-dependent glucose transporter (SGLT1) and peptide transporter (PepT1) were up-regulated due to BMD and BA supplementation. However, at 21 days post-hatching SGLT1 expression in the BMD-supplemented group was down-regulated with respect to the BA-supplemented groups. The 4 g BA/kg diet yielded better humoral and cell-mediated immune responses than the other groups. No dietary effects were observed on carcase characteristics and histomorphometry of jejunum at 7 days post-hatching. However, at 42 days old, the 4 g BA/kg diet increased villus length and width significantly. There was a significant increase in serum protein, albumin, creatinine, aspartate aminotransaminase (AST), phosphorus and calcium due to BA supplementation. However, the reverse trend was observed in serum uric acid and cholesterol, where BA supplementation decreased both and BMD supplementation decreased uric acid levels only. Based on the results it was concluded that 4 g BA/kg diet supplementation in feed is optimal for desirable broiler production.

Keywords

Broiler performancebutyric acidgut histomorphometryimmunitynutrient transportersserum
Type
Animal Research Paper
Information
The Journal of Agricultural Science , Volume 157 , Issue 1 , January 2019 , pp. 55 - 62
Copyright
Copyright © Cambridge University Press 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abdel-Fattah, SA, El-Sanhoury, MH, El-Mednay, NM and Abdel-Azeem, F (2008) Thyroid activity, some blood constituents, organs morphology and performance of broiler chicks fed supplemental organic acids. International Journal of Poultry Science 7, 215–222.Google Scholar
Adibi, SA (1997) The oligopeptide transporter (PepT-1) in human intestine: Biology and function. Gastroenterology 113, 332–340.Google Scholar
Adil, S, Banday, T, Bhat, GA, Mir, MS and Rehman, M (2010) Effect of dietary supplementation of organic acids on performance, intestinal histomorphology, and serum biochemistry of broiler chicken. Veterinary Medicine International 10, Article ID 479485. doi:10.4061/2010/479485.Google Scholar
Ahsan, U, Cengiz, O, Raza, I, Kuter, E, Chacher, MFA, Iqbal, Z, Umar, S and Çakir, S (2016) Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity. World's Poultry Science Journal 72, 265–275.Google Scholar
Ali, AM, Seddiek, SA and Khater, HF (2014) Effect of butyrate, clopidol and their combination on the performance of broilers infected with Eimeria maxima. British Poultry Science 55, 474–482.Google Scholar
Ao, Z, Kocher, A and Choct, M (2012) Effects of dietary additives and early feeding on performance, gut development and immune status of broiler chickens challenged with Clostridium perfringens. Asian-Australasian Journal of Animal Science 25, 541–551.Google Scholar
Ashraf, S, Zaneb, H, Yousaf, MS, Ijaz, A, Sohail, MU, Muti, S, Usman, MM, Ijaz, S and Rehman, H (2013) Effect of dietary supplementation of prebiotics and probiotics on intestinal microarchitecture in broilers reared under cyclic heat stress. Journal of Animal Physiology Animal Nutrition 97(suppl. S1), 68–73.Google Scholar
Baginski, ES, Marie, SS, Clark, WL and Zak, B (1973) Direct microdetermination of serum calcium. Clinica Chimica Acta 46, 49–54.Google Scholar
Boling, SD, Douglas, MW, Snow, JL, Parsons, CM and Baker, DH (2000) Citric acid does not improve phosphorus utilization in laying hens fed a corn-soybean meal diet. Poultry Science 79, 1335–1337.Google Scholar
Brouns, F, Kettlitz, B and Arrigoni, E (2002) Resistant starch and ‘the butyrate revolution’. Trends in Food Science and Technology 13, 251–261.Google Scholar
Chomczynski, P (1993) A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. BioTechniques 15, 532–537.Google Scholar
Dierick, NA, Vervaeke, IJ, Decuypere, JA and Henderickx, HK (1986) Influence of the gut flora and of some growth-promoting feed additives on nitrogen metabolism in pigs. II. Studies in vivo. Livestock Production Science 14, 177–193.Google Scholar
Gilbert, ER, Wong, EA and Webb, KE (2008) Board-invited review: Peptide absorption and utilization: Implications for animal nutrition and health. Journal of Animal Science 86, 2135–2155.Google Scholar
Gustafsson, JE (1978) Automated serum albumin determination by use of the immediate reaction with bromocresol green reagent. Clinical Chemistry 24, 369–373.Google Scholar
Harada, E, Hiroko, K, Kobayashi, E and Tsuchita, H (1988) Postnatal development of biliary and pancreatic exocrine secretion in piglets. Comparative Biochemistry and Physiology Part A: Physiology 91, 43–51.Google Scholar
Hedayati, M, Manafi, M, Khalaji, S, Yari, M, Esapour, A, Nazari, A and Mohebi, F (2015) Combination effect of probiotic and organic acids on blood biochemistry and immunity parameters of broilers. International Journal of Agriculture Innovations and Research 3, 1188–1193.Google Scholar
Helal, MS, Youssef, FM, Moursi, MK, Khalil, WF and Abdel-Daim, MM (2015) Effectiveness of prebiotic as an alternative to the antimicrobial growth promoter on growth performance, blood constituents, intestinal healthiness and immunity of broilers. Alexandria Journal of Veterinary Science 45, 13–25.Google Scholar
Kamal, AM and Ragaa, NM (2014) Effect of dietary supplementation of organic acids on performance and serum biochemistry of broiler chicken. Nature and Science 12, 38–45.Google Scholar
Kind, PRN and King, EJ (1954) Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. Journal of Clinical Pathology 7, 322–326.Google Scholar
Kirchgessner, M and Roth, FX (1988) Ergotrope efekte durch organische suaren in der ferkelaufzucht und schweinemast. Ubersichten zur Tierernahrung 16, 93–108.Google Scholar
Klaver, FA and van der Meer, R (1993) The assumed assimilation of cholesterol by lactobacilli and Bifidobacterium bifidum is due to their bile salt-deconjugating activity. Applied and Environmental Microbiology 59, 1120–1124.Google Scholar
Langhout, P (2000) New additives for broiler chickens. Feed Mix 18, 24–27.Google Scholar
Le Gall, M, Gallois, M, Sève, B, Louveau, I, Holst, JJ, Oswald, IP, Lallès, JP and Guilloteau, P (2009) Comparative effect of orally administered sodium butyrate before or after weaning on growth and several indices of gastrointestinal biology of piglets. British Journal of Nutrition 102, 1285–1296.Google Scholar
Leeson, S, Namkung, H, Antongiovanni, M and Lee, EH (2005) Effect of butyric acid on the performance and carcass yield of broiler chickens. Journal of Poultry Science 84, 1418–1422.Google Scholar
Lohakare, JD, Ryu, MH, Hahn, TW, Lee, JK and Chae, BJ (2005) Effects of supplemental ascorbic acid on the performance and immunity of commercial broilers. Journal of Applied Poultry Research 14, 10–19.Google Scholar
Morin, LG and Prox, J (1973) New and rapid procedure for serum phosphorus using o-phenylenediamine as reductant. Clinica Chimica Acta 46, 113–117.Google Scholar
Mott, CR, Siegel, PB, Webb, KE Jr and Wong, EA (2008) Gene expression of nutrient transporters in the small intestine of chickens from lines divergently selected for high or low juvenile body weight. Poultry Science 87, 2215–2224.Google Scholar
Panda, AK, Rama Rao, SV, Raju, MVLN and Shyam Sunder, G (2009) Effect of butyric acid on performance, gastrointestinal tract health and carcass characteristics in broiler chickens. Asian-Australasian Journal of Animal Science 22, 1026–1031.Google Scholar
Reitman, S and Frankel, S (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology 28, 56–63.Google Scholar
Sengupta, S, Muir, JG and Gibson, PR (2006) Does butyrate protect from colorectal cancer? Journal of Gastroenterology and Hepatology 21, 209–218.Google Scholar
Sharma, R, Schumacher, U, Ronaasen, V and Coates, M (1995) Rat intestinal mucosal responses to a microbial flora and different diets. Gut 36, 209–214.Google Scholar
Sikandar, A, Zaneb, H, Younus, M, Masood, S, Aslam, A, Khattak, F, Ashraf, S, Yousaf, MS and Rehman, H (2017) Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens. Asian-Australasian Journal of Animal Sciences 30, 690–699.Google Scholar
Steel, A, Nussberger, S, Romero, MF, Boron, WF, Boyd, CA and Hediger, MA (1997) Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1. Journal of Physiology 498, 563–569.Google Scholar
Sunkara, LT, Achanta, M, Schreiber, NB, Bommineni, YR, Dai, G, Jiang, W, Lamont, S, Lillehoj, HS, Beker, A, Teeter, RG and Zhang, G (2011) Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression. PLoS One 6, e27225.Google Scholar
Surono, IS (2003) In vitro probiotic properties of indigenous dadih lactic acid bacteria. Asian-Australasian Journal of Animal Science 16, 726–731.Google Scholar
Thompson, JL and Hinton, M (1997) Antibacterial activity of formic and propionic acids in the diet of hens on Salmonellas in the crop. British Poultry Science 38, 59–65.Google Scholar
Van Immerseel, F, Fievez, V, de Buck, J, Pasmans, F, Martel, A, Haesebrouck, F and Ducatelle, R (2004) Microencapsulated short-chain fatty acids in feed modify colonization and invasion early after infection with Salmonella enteritidis in young chickens. Poultry Science 83, 69–74.Google Scholar
Vatzidis, H (1977) An improved biuret reagent. Clinical Chemistry 23, 908.Google Scholar
Wright, EM and Turk, E (2004) The sodium/glucose cotransporter family SLC5. European Journal of Physiology 447, 510–518.Google Scholar
Wybenga, DR, Pileggi, VJ, Dirstine, PH and di Giorgio, J (1970) Direct manual determination of serum total cholesterol with a single stable reagent. Clinical Chemistry 16, 980–984.Google Scholar
Yang, Y, Iji, PA and Choct, M (2009) Dietary modulation of gut microflora in broiler chickens: a review of the role of six kinds of alternatives to in-feed antibiotics. World's Poultry Science Journal 65, 97–114.Google Scholar
Zhou, ZY, Packialakshmi, B, Makkar, SK, Dridi, S and Rath, NC (2014) Effect of butyrate on immune response of a chicken macrophage cell line. Veterinary Immunology and Immunopathology 162, 24–32.Google Scholar