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The relationship between serum albumin concentration and body protein loss in pregnant sheep

Published online by Cambridge University Press:  27 March 2009

A. R. Sykes  and
R. Thompson
A. R. Sykes
Affiliation:
Moredun Research Institute, Edinburgh, EH11 7JH
R. Thompson
Affiliation:
A.R.C. Unit of Statistics, Mayfield Road, Edinburgh EH9 3JZ
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Summary

Data are presented from 104 sheep from three separate sources (batches) in which variation in the degree of maternal body protein loss was induced by nutritional means. The change in body protein content during pregnancy was calculated as the difference between body protein content in early pregnancy, predicted from the relationship with body weight in control sheep killed in early pregnancy, and actual content on slaughter at parturition. Serum albumin and globulin concentrations and body weight were measured at intervals during pregnancy and examined for relationships with body protein change.

Highly significant linear relationships were found between the change (%) in albumin concentration during pregnancy or albumin concentration in late pregnancy and the calculated change (%) in maternal body protein content (P < 0·001 in both cases) though fitting separate intercepts for each batoh of sheep led to improvements in fit.

Equations for prediction of loss (%) of body protein from change in body weight or maternal body weight during pregnancy though significant, were also improved by fitting separate intercepts for batches. The relative value of the relationships for predicting body protein loss is discussed.

Serum globulin concentration was not affected by protein status of the animal.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 91 , Issue 1 , August 1978 , pp. 173 - 179
Copyright
Copyright © Cambridge University Press 1978

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References

Allen, W. M., Berrett, S. & Patterson, D. S. P. (1974). A biochemical study of experimental Johne's disease. 1. Plasma protein leakage into the intestine of sheep. Journal of Comparative Pathology 84, 381–384.CrossRefGoogle Scholar
Anderson, N., Armour, J., Jarrett, W. H. F., Jennings, F. W., Ritchie, J. S. D. & Urquhart, G. M. (1965). A field study of parasitic gastritis in cattle. Veterinary Record 77, 1196–1204.CrossRefGoogle ScholarPubMed
Barcroft, J., Kennedy, J. A. & Mason, M. F. (1939). Blood volume and kindred properties in pregnant sheep. Journal of Physiology, London 95, 159–172.CrossRefGoogle ScholarPubMed
Blaxter, K. L. (1962). The Energy Metabolism of Ruminants. London: Hutchinson.Google Scholar
Campbell, R. M., Cuthbertson, D. P., Mackie, W., McFarlane, A. S., Phillipson, A. T. & Sudsaneh, S. (1961). Passage of albumin into the intestine of sheep. Journal of Physiology, London 158, 113–131.CrossRefGoogle Scholar
Christopherson, R. J. & Webster, A. J. F. (1972). Change during eating in oxygen consumption cardiac function and body fluids of sheep. Journal of Physiology, London 221, 441–457.CrossRefGoogle ScholarPubMed
Coop, R. L., Sykes, A. R. & Angus, K. W. (1976). Subclinical trichostrongylosis in growing lambs produced by continuous larval dosing. Its effect on performance and certain plasma constituents. Research in Veterinary Science 85, 549–559.Google Scholar
Coop, R. L., Sykes, A. R. & Angus, K. W. (1977). The influence of chronic Ostertagia circumcincta infection on the skeleton of growing sheep. Journal of Comparative Pathology 87, 521–529.Google Scholar
Fell, B. F., Regoeozi, E., Campbell, R. M. & Mackie, W. S. (1969). The permeability for 131IPVP of the normal and hypertrophied gastrointestinal tract of sheep. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 54, 141–155.Google Scholar
Holmes, P. H. & Maclean, J. M. (1971). The pathophysiology of ovine ostertagiasis: A study of the changes in plasma protein metabolism following single infections. Research in Veterinary Science 12, 265–271.CrossRefGoogle ScholarPubMed
Hytten, F. B. & Leitch, I. (1964). The Physiology of Human Pregnancy. Oxford: Blackwell Scientific Publications.Google Scholar
Jarnum, S. (1962). In Protein-losing Oastroenteropathy. 1st ed.Oxford: Blackwell Scientific Publications.Google Scholar
Kirsch, R., Frith, L., Black, E. & Hoffenberg, R. (1968). Regulations of albumin synthesis and catabolism by alteration of dietary protein. Nature, London 217, 578–579.CrossRefGoogle ScholarPubMed
Mackie, W. S. & Fell, B. F. (1971). The half-life of serum albumin in relation to liver hypertrophy in the lactating ewe. Research in Veterinary Science 12, 54–58.Google Scholar
Meat and Livestock Commission (1973). Feeding the ewe. Sheep Improvement Service– technical report no. 2.Google Scholar
Morgan, E. H. & Peters, T. (1971). The biosynthesis of rat serum albumin. V. Effect of protein depletion and refeeding on albumin and transferrin synthesis. Journal of Biological Chemistry 246, 3500–3507.CrossRefGoogle ScholarPubMed
Mulligan, W. (1972). The effect of helminthic infection on the protein metabolism of the host. Proceedings of the Nutrition Society 31, 47–51.Google Scholar
Payne, J. M., Dew, S. M., Manston, R. & Faulks, M. (1970). The use of a metabolic profile test in dairy herds. Veterinary Record 87, 150–158.Google Scholar
Sykes, A. R. (1976). An assessment of the value of plasma urea N and albumin concentrations as monitors of the protein status of sheep. In Blood Profiles in Animal Production. Occasional publication no. 1, British Society of Animal Production 1977, pp. 143–154.Google Scholar
Sykes, A. R. & Coop, R. L. (1976). Intake and utilization of food by growing lambs with parasitic damage to the small intestine caused by daily dosing with Trichostrongylus colubriformis larvae. Journal of Agricultural Science, Cambridge 86, 507–515.Google Scholar
Sykes, A. R. & Coop, R. L. (1977). Intake and utilization of food by growing sheep with parasitic damage to the abomasum caused by daily dosing with Ostertagia circumcincta larvae. Journal of Agricultural Science, Cambridge 88, 671–677.Google Scholar
Sykes, A. R. & Dingwall, R. A. (1975). Calcium absorption during lactation in sheep with demineralized skeletons. Journal of Agricultural Science, Cambridge 84, 245–248.Google Scholar
Sykes, A. R. & Dingwall, R. A. (1976). The phosphorus requirement of pregnant sheep. Journal of Agricultural Science, Cambridge 86, 587–594.Google Scholar
Sykes, A. R. & Field, A. C. (1972). Effects of dietary deficiencies of energy, protein and calcium on the pregnant ewe. 1. Body composition and mineral content of the ewes. Journal of Agricultural Science, Cambridge 78, 109–117.CrossRefGoogle Scholar
Sykes, A. R. & Field, A. C. (1973). Effects of dietary deficiencies of energy, protein and calcium on the pregnant ewe. IV. Serum total protein, albumin, transferrin and plasma urea levels. Journal of Agricultural Science, Cambridge 80, 29–36.Google Scholar
Sykes, A. R. & Field, A. C. (1974). Seasonal changes in plasma concentration of proteins, urea, glucose, calcium and phosphorus in sheep grazing a hill pasture and their relationship to changes in body composition. Journal of Agricultural Science, Cambridge 83, 161–169.Google Scholar
Sykes, A. R., Nisbet, D. I. & Field, A. C. (1973). Effects of dietary deficiencies of energy, protein and calcium on the pregnant ewe. V. Chemical analyses and histological examination of some individual bones. Journal of Agricultural Science, Cambridge 81, 433–440.CrossRefGoogle Scholar
Tebnouth, J. H. (1968). Changes in the thiosulphate space and some constituents of the blood after feeding. Research in Veterinary Science 9, 345–349.Google Scholar