A significant proportion of wheat (Triticum aestivum L.) yield increases achieved at the farm level in the past can be attributed to improved crop management practices. The important role of crop management practices in increasing the yield potential in wheat sustainably is illustrated with recent research findings from North Dakota. In the dryer regions, no-till and crop rotations significantly improve yield and protect the productivity of the soil. Intensifying management in the wetter regions through increased plant populations and by nitrogen timing did not increase yield in 2005 while fungicide applied at flowering for scab control did. In one study genotype interacted with management, with the most disease-tolerant genotypes producing the highest yield when treated with fungicides. Identifying and exploiting positive genotype by management interactions offers a potential avenue for increasing yield potential in wheat in the future. Identifying or developing crop management practices that hold potential for synergistically improving the yield of genotypes is a significant challenge. Imposing management practices that hold promise for improving yield sustainably on breeding material during the selection process has scope for identifying genotypes with greater yield potential at the farm level when these management practices are employed.