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The genetic control of erythrocyte reduced glutathione in Australian Merino sheep

Published online by Cambridge University Press:  27 March 2009

P. G. Board
Affiliation:
Department of Physiology, University of New England, Armidale N.S.W. 2350, Australia
J. Roberts
Affiliation:
Department of Physiology, University of New England, Armidale N.S.W. 2350, Australia
J. V. Evans
Affiliation:
Department of Physiology, University of New England, Armidale N.S.W. 2350, Australia

Summary

The genetic control of the level of reduced glutathione (GSH) in the erythrocytes of pure bred Australian Merino sheep has been investigated. The data suggest that the erythrocyte GSH levels are in part controlled by a single pair of autosomal alleles, the gene for GSH-high (GSHH) being dominant.

The data also suggest that the levels of erythrocyte GSH within the GSH-high and GSH-low types are the result of polygenic influences. Heritability estimates of 0·7 and 0·5 within the GSH-high type and 1·2 in the GSH-low type support this suggestion.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1974

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References

REFERENCES

Agar, N. S., Roberts, J. & Evans, J. V. (1972). Erythrocyte glutathione polymorphism in sheep. Australian Journal of Biological Sciences 25, 619–26.CrossRefGoogle ScholarPubMed
Brown, R. V., Goodman, M. & Gavan, J. A. (1970). Glutathione and transferrin in rhesus monkeys. Animal Blood Groups and Biochemical Genetics 1, 189–94.CrossRefGoogle Scholar
El-Hawary, M. F. S., El-Din, H. B., Safty, A. & Abdela, S. (1968). Seasonal variation in blood glutathione in guinea pigs. Journal of Egyptian Medical Association 51, 3640.Google ScholarPubMed
Ellory, J. C., Tucker, , Elizabeth, M. & Deverson, E. V. (1972). The identification of ornithine and lysine at high concentration in red cells of sheep with an inherited deficiency of glutathione. Biochimica et Biophysica Acta 279, 481–3.CrossRefGoogle ScholarPubMed
Evans, J. V. (1954). Electrolyte concentrations in red blood cells of British breeds of sheep. Nature, London 174, 931.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1960). Introduction to Quantitative Genetics, p. 173. Edinburgh: Oliver and Boyd.Google Scholar
Falconer, D. S. (1963). In Methodology in Quantitative Mammalian Genetics (ed. Burdette, W. J.), p. 203. San Francisco: Holden-Day Inc.Google Scholar
Goldschmidt, L. (1970). Seasonal variations in red cell glutathione levels with aging in mental patients and normal controls. Proceedings of the Society for Experimental Biology and Medicine 133, 555–9.CrossRefGoogle ScholarPubMed
Kldwell, J. F., Bohman, V. R., Wade, M. A. & Hunter, J. E. (1958). An investigation of blood glutathione levels in sheep. Growth 22, 6371.Google Scholar
Kunkel, H. O., Stutts, E. C. & Shrode, R. (1954). The individuality of the level of blood glutathione in young beef cattle. Journal of Animal Science 13, 852–8.CrossRefGoogle Scholar
Roberts, J. & Agar, N. S. (1971). An improved method for the automated analysis of erythrocyte reduced glutathione. Clinica Chimica Acta 34, 475–80.CrossRefGoogle ScholarPubMed
Saltykov, F. I. (1956). The diagnostic importance of blood glutathione in estimating the wool production of fine wooled sheep. Byull. nauchno-tekh. Inf. Ukr. Askanija Nova 1, 2931 [cited in Animal Breeding Abstracts 26, 837 (1958)].Google Scholar
Shabalina, A. & Yotsov, S. (1967). Genetic studies on the glutathione content of the blood of the domestic fowl. Vet. Med. Nanki. 4, 1320 [cited in Biological Abstracts 49, 11958 (1968)].Google Scholar
Smith, J. E. & Osburn, B. I. (1967). Glutathione deficiency in sheep erythrocytes. Science, N.Y. 158, 374–5.CrossRefGoogle ScholarPubMed
Snedecor, G. W. (1946). Statistical Methods: Applied to Experiments in Agriculture and Biology, 4th edition, 10.8. Iowa: Iowa State College Press.Google Scholar
Stuffelbeam, C. E., Wilson, L. L., Mayer, D. T., Day, B. N., Comfort, J. E. & Lasley, J. F. (1964). Seasonal variation in levels of some chemical and hematological components in the blood of Hereford cows. Research Bulletin 859. University of Missouri, College of Agriculture, Agricultural Experimental Station.Google Scholar
Stutts, E. C., Johnson, W., Briles, W. E. & Kunkel, H. O. (1956). Variation in reduced glutathione in blood of inbred lines of chickens. Society for Experimental Biology and Medicine Proceedings 91, 60–3.CrossRefGoogle ScholarPubMed
Tucker, Elizabeth M. & Ellory, J. C. (1971). The cation composition of red cells of sheep with an inherited deficiency of reduced glutathione. Research in Veterinary Science 12, 600–2.CrossRefGoogle ScholarPubMed
Tucker, Elizabeth M. & Kilgour, L. (1970). An inherited glutathione deficiency and a concomitant reduction in potassium concentration in sheep red cells. Experientia 26, 203–4.CrossRefGoogle Scholar
Tucker, Elizabeth M. & Kilgour, L. (1972). A glutathione deficiency in red cells of certain Merino sheep. Journal of Agricultural Science, Cambridge 79, 515–16.CrossRefGoogle Scholar