Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-28T17:20:30.495Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of selection for glucose tolerance in sheep on carcass fat and plasma glucose, urea and insulin

Published online by Cambridge University Press:  27 March 2009

S. M. Francis ,
R. Bickerstaffe ,
J. N. Clarke ,
D. O'Connell  and
A. P. Hurford
S. M. Francis
Affiliation:
Ministry of Agriculture & Fisheries, Canterbury Agriculture & Science Centre, Lincoln, Canterbury, New Zealand
R. Bickerstaffe
Affiliation:
Department of Biochemistry and Microbiology, Lincoln University, Canterbury, New Zealand
J. N. Clarke
Affiliation:
AgResearch, Ruakura Agricultural Centre, Private Bag, Hamilton, New Zealand
D. O'Connell
Affiliation:
AgResearch, Canterbury Agriculture & Science Centre, PO Box 60, Lincoln, Canterbury, New Zealand
A. P. Hurford
Affiliation:
AgResearch, Ruakura Agricultural Centre, Private Bag, Hamilton, New Zealand
Get access Rights & Permissions [Opens in a new window]

Summary

Over 5 years (1987–91), the progeny of rams selected for fast (Low T-half) or slow (High T-half) glucose clearance after an intravenous glucose tolerance test, differed significantly in glucose tolerance. In comparison with an unselected control, the line differences were mainly in the direction of Low T-half. They appear to have arisen during the establishment period, with little evidence of enhanced divergence over the four subsequent years of continued selection (heritability 0·10±0·03). The Low line had higher plasma insulin concentrations during the glucose tolerance test than the High line. Basal plasma concentrations of glucose were lower, and urea higher in the Low than the High line. In addition, carcasses of Low line ram progeny had more subcutaneous fat at the same carcass weight than High line carcasses (11% higher GR in the final year of the experiment). Selection of sheep for glucose clearance appeared to be associated with differential partitioning of nutrients into adipose tissue, the pooled genetic correlation between T-half and GR being −0·28±0·13.

Type
Animals
Information
The Journal of Agricultural Science , Volume 123 , Issue 2 , October 1994 , pp. 279 - 286
Copyright
Copyright © Cambridge University Press 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Albano, J. & Ekins, R. P. (1970). The attainment of high sensitivity and precision in radioimmunoassay techniques as exemplified in a single assay of serum insulin. In In Vitro Procedure with Radioisotopes in Medicine, pp. 491–513. Vienna: International Atomic Energy Agency.Google Scholar
Bassett, J. M. (1978). Endocrine factors in the control of nutrient utilization: ruminants. Proceedings of the Nutrition Society 37, 273–280.CrossRefGoogle ScholarPubMed
Bickerstaffe, R. (1993). Regulation of nutrient partitioning in growth and lactation. Australian Journal of Agricultural Research 44, 523–539.CrossRefGoogle Scholar
Blair, H. T. (1989). Practical procedures for the genetic improvement of growth and carcass quality characteristics. In Meat Production and Processing (Eds Purchas, R. W., Butler-Hogg, B. W. & Davies, A. S.), pp. 125–141. New Zealand Society of Animal Production Occasional Publication Number 11.Google Scholar
Blair, H. T., Mccutcheon, S. N. & Mackenzie, D. D. S. (1990). Physiological predictors of genetic merit. In Proceedings of the Eighth Australian Association of Animal Breeding and Genetics, pp. 133–142.Google Scholar
Bray, A. R, Taylor, A. G., Burton, R. N. & Moss, R. A. (1988). Leanness of young sheep that lost weight after shearing. Proceedings of the New Zealand Society of Animal Production 48, 37–39.Google Scholar
Brockman, R. P. (1978). Roles of glucagon and insulin in the regulation of metabolism in ruminants – a review. Canadian Veterinary Journal 19, 55–62.Google ScholarPubMed
Brockman, R. P. & Laarveld, B. (1986). Hormonal regulation of metabolism in ruminants: a review. Livestock Production Science 14, 313–334.CrossRefGoogle Scholar
Cama, A., de la Luz Sierra, M., Ottini, L, Kadowaki, T., Gorden, P., Imperato-McGinley, J. & Taylor, S. I. (1991). A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman. Journal of Clinical Endocrinology and Metabolism 73, 894–901.CrossRefGoogle Scholar
Cameron, N. D. (1992). Correlated responses in slaughter and carcass traits of crossbred progeny to selection for carcass lean content in sheep. Animal Production 54, 379–388.Google Scholar
Carter, M. L, McCutcheon, S. N. & Purchas, R. W. (1989). Plasma metabolite and hormone concentrations as predictors of genetic merit for lean meat production in sheep: effects of metabolic challenges and fasting. New Zealand Journal of Agricultural Research 32, 343–353.CrossRefGoogle Scholar
Clarke, J. N., Waldron, D. F. & Rae, A. L. (1992). Selection objectives and criteria for terminal lamb sires. In Proceedings of the Ninth Australian Association of Animal Breeding and Genetics, pp. 265–271.Google Scholar
Cropper, M. R. (1989). Changing the body composition of sheep by feeding. Proceedings of the New Zealand Society of Animal Production 49, 121–126.Google Scholar
Croston, D., Kempster, A. J., Guy, D. R. & Jones, D. W. (1987). Carcass composition of crossbred lambs by ten sire breeds compared at the same carcass subcutaneous fat proportion. Animal Production 44, 99–106.Google Scholar
Fennessy, P. F., Greer, G. J., Bain, W. E. & Johnstone, P. D. (1993). Progeny test of ram lambs selected for low ultrasonic backfat thickness or high post-weaning growth rate. Livestock Production Science 33, 105–118.CrossRefGoogle Scholar
Francis, S. M., Bickerstaffe, R., O'connell, D., Munro, J. M. & Parratt, A. P. (1988). Using biochemical parameters for genetic selection of carcass quality in lambs. Proceedings of the Nutrition Society of New Zealand 13, 156.Google Scholar
Francis, S. M., Bickerstaffe, R. & Parratt, A. C. (1989). Genetic selection of animals differing in obesity using a biochemical parameter. Journal of Cellular Biochemistry Supplement 13E, 244.Google Scholar
Francis, S. M., Bickerstaffe, R. & O'connell, D. (1990 a). Genetic selection for leanness using a biochemical parameter. In Proceedings of the Eighth Australian Association of Animal Breeding and Genetics, pp. 143–146.Google Scholar
Francis, S. M., Bickerstaffe, R. & O'connell, D. (1990 b). The insulin status of sheep with genetic differences in glucose tolerance and carcass composition. Proceedings of the New Zealand Society of Animal Production 50, 93–96.Google Scholar
Hunter, W. M. & Greenwood, F. C. (1962). Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature 194, 495–496.CrossRefGoogle ScholarPubMed
Jeanrenaud, B. (1978). Hyperinsulinemia in obesity syndromes: its metabolic consequences and possible etiology. Metabolism 27 (Supplement 2), 1881–1892.CrossRefGoogle ScholarPubMed
Kennedy, A. D., Tekpetey, F. R. & Jones, S. D. M. (1988). Use of mononuclear leukocyte insulin receptor characteristics as predictors of carcass composition in heifers and steers. Journal of Animal Science 66, 2448–2458.CrossRefGoogle ScholarPubMed
Kern, M., Wells, J. A., Stephens, J. M., Elton, C. W., Friedman, J. E., Tapscott, E. B., Pekala, P. H. & Dohm, G. L. (1990). Insulin responsiveness in skeletal muscle is determined by glucose transporter (GLUT4) protein level. Biochemistry Journal 270, 397–400.CrossRefGoogle ScholarPubMed
Kirton, A. H. & Johnson, D. L. (1979). Interrelationships between GR and other lamb carcass fatness measurements. Proceedings of the New Zealand Society of Animal Production 39, 194–201.Google Scholar
McCann, J. P. & Bergman, E. N. (1988). Endocrine and metabolic factors in obesity. In Aspects of Digestive Physiology in Ruminants (Eds Dobson, A. & Dobson, M. J.), pp. 175–202. Cornell: Comstock Publishing Associates.Google Scholar
Mead, J. F., Alfin-Slater, R. B., Howton, D. R. & Popják, G. (1986). Nutritional value of lipids. In Lipids: Chemistry, Biochemistry, and Nutrition, pp. 459–473. New York: Plenum Press.CrossRefGoogle Scholar
Menotti, A. & Seccareccia, F. (1987). The significance of dietary fat for metabolic diseases and atherosclerosis in particular. In Fat Production and Consumption: Technologies and Nutritional Implications (Eds Galli, C. & Fedeli, E.), pp. 27–36. New York: Plenum Press.CrossRefGoogle Scholar
Meyer, K. (1986). Restricted maximum likelihood for data with hierarchical genetic structures. Proceedings of the World Congress on Genetics Applied to Livestock Production XII, 397–402.Google Scholar
Munro, J. M. (1992). Factors influencing insulin yield and secretion from the ovine pancreas. PhD thesis, University of Canterbury, New Zealand.Google Scholar
Munro, J. M., Bickerstaffe, R., Geenty, K. G. & Willis, J. A. (1985). Induction of insulin resistance by prolonged suckling or administration of exogenous insulin in lambs. Proceedings of the Nutrition Society of New Zealand 10, 78.Google Scholar
Pedersen, O., Kahn, C. R., Flier, J. S. & Kahn, B. B. (1991). High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. Endocrinology 129, 771–777.CrossRefGoogle Scholar
Pessin, J. E. & Bell, G. I. (1992). Mammalian facilitative glucose transporter family: structure and molecular regulation. Annual Review of Physiology 54, 911–930.CrossRefGoogle ScholarPubMed
Peters, A. R. (1989). β-agonists as repartitioning agents: a review. Veterinary Record 124, 417–420.CrossRefGoogle ScholarPubMed
Stolz, D. J. & Martin, R. J. (1982). Role of insulin in food intake, weight gain and lipid deposition in the Zucker obese rat. Journal of Nutrition 112, 997–1002.CrossRefGoogle ScholarPubMed
Thonney, M. L., Taylor, St. C. S., Murray, J. I. & McClelland, T. H. (1987). Breed and sex differences in equally mature sheep and goats. 2. Body components at slaughter. Animal Production 45, 261–276.Google Scholar
Trenkle, A. & Topel, D. G. (1978). Relationships of some endocrine measurements to growth and carcass composition of cattle. Journal ofAnimal Science 46, 1604–1609.Google Scholar
Waldron, D. F., Clarke, J. N., Rae, A. L., Kirton, A. H. & Bennett, G. L. (1992). Genetic and phenotypic estimates for selection to improve lamb carcass traits. New Zealand Journal of Agricultural Research 35, 287–298.CrossRefGoogle Scholar
Wastney, M. E., Arcus, A. C., Bickerstaffe, R. & Wolff, J. E. (1982). Glucose tolerance in ewes and susceptibility to pregnancy toxaemia. Australian Journal of Biological Sciences 35, 381–392.CrossRefGoogle ScholarPubMed
Wolff, J. E., Dobbie, P. M. & Petrie, D. R. (1989). Anabolic effects of insulin in growing lambs. Quarterly Journal of Experimental Physiology 74, 451–463.CrossRefGoogle ScholarPubMed
Young, M. J. & Simm, G. (1990). Responses to selection for lean tissue growth in Suffolk sheep – preliminary results. In Proceedings of the Eighth Australian Association of Animal Breeding and Genetics, pp. 555–556.Google Scholar