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The use of clozapine in an individual with moderate intellectual disability, aggressive behaviour and resistant psychosis

Published online by Cambridge University Press:  13 June 2014

Manzar Kamal  and
Mary Kelly
Manzar Kamal
Affiliation:
St. Mary's, Drumcar, Co Louth, Ireland
Mary Kelly
Affiliation:
St. Mary's, Drumcar, Co Louth, Ireland
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Abstract

The case of a 32 year old man with moderate intellectual disability, severe behavioural problems and psychotic symptoms is described. Having tried various traditional antipsychotics he was commenced on clozapine with a marked improvement in symptoms. Clozapine is a useful drug for the treatment of schizophrenia in the intellectually disabled who are refractory to the conventional antipsychotics. It improves aggressive and self-injurious behaviour which may be in addition to its antipsychotic effect.

Keywords

Moderate intellectual disabilityTreatment resistant psychosisClozapine
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 16 , Issue 1 , March 1999 , pp. 32 - 33
Copyright
Copyright © Cambridge University Press 1999

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References

1.Sovner, R. Is it behaviour or mental illness?Paper presented to PBA Consultants. Pittsburgh: 1991 October.Google Scholar
2.Vynke, J. The treatment of behaviour disorders in idiocy and imbecility with clozapine. Pharmacopsychiatry 1974; 7: 225–9.CrossRefGoogle Scholar
3.Cohen, SA, Underwood, MT. The use of clozapine in a mentally retarded and aggressive population. J Clin Psychiatry 1994; 55: 440–4.Google Scholar
4.Sajatovic, Met al.The use of clozapine in borderline intellectual functioning and mentally retarded schizophrenic patients. Compr Psychiatry 1994; 35: 29–33.CrossRefGoogle ScholarPubMed
5.Pary, RJ. Clozapine in three individuals with mild mental retardation and treatment refractory psychiatric disorders. Ment Retard 1994; 32: 323–7.Google ScholarPubMed
6.Boachie, A, McGinnity, M. Use of clozapine in a mental hospital – report of the first 17 patients. Ir J Psych Med 1997; 14(1): 16–9.CrossRefGoogle Scholar
7.Breese, GRet al.Behavioural differences between neonatal and six adult hydroxydopamine treated rats to dopamine agonists: relevance to neurological symptoms in clinical syndromes with reduced brain dopamine. J Pharmacol Exp Ther 1984a; 231: 343–54.Google Scholar
8.Breese, GRet al.Pharmacological evaluation of SCH-12679: Evidence of an in vivo antagonism of Dl dopamine receptors. J Pharmacol Exp Ther 1990; 252: 558–76.Google Scholar