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The secondary sexual characteristics of the brain

Published online by Cambridge University Press:  13 June 2014

C S Breathnach
C S Breathnach*
Affiliation:
Department of Physiology, University College, Earlsfort Terrace, Dublin 2
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Abstract

In the avian cerebrum and in the spinal cord, sympathetic ganglia, hypothalamico pre-optic area and cerebral cortex of the rat sexually dimorphic' nuclei are clearly recognisable. Similar differences have been described in the human brain. Morphometric analysis has shown a sexually dimorphic nucleus in the pre-optic area. There is continuing controversy over differences in the size and shape of the corpus callosum, but there is accumulating evidence of cerebral asymmetry with more focal representation of language and praxic functions in the left cerebral hemisphere in females. The various sensory modalitites also show gender differences. The significance of these secondary sexual variations in brain structure resides in the developmental and behavioural characteristics of the underlying neural circuits.

Keywords

Avian song nucleiNucleus of bulbocavernosusPre-optic areaHemispheric asymmetrySensory modalitiesSexual dimorphism
Type
Review Articles
Information
Irish Journal of Psychological Medicine , Volume 7 , Issue 1 , March 1990 , pp. 59 - 63
Copyright
Copyright © Cambridge University Press 1990

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References

1.Nottebohm, F, Arnold, AP. Sexual dimorphism in vocal control areas of the songbird brain. Science 1976; 194: 211–13.CrossRefGoogle ScholarPubMed
2.Nottebohm, F. A brain for all seasons; cyclical anatomical changes in song control nuclei of the canary brain. Science 1981; 214: 1366–76.CrossRefGoogle Scholar
From birdsong to neurogenesis. Scientific American 1989, 260: 56–61.Google Scholar
3.Paton, A, Nottebohm, F. Neurons generated in the adult brain are recruited into functional circuits. Science 1984; 225: 1046–48.CrossRefGoogle ScholarPubMed
4.De Voogd, TJ, Nottebohm, F. Sex differences in dendritic morphology of a song control nucleus in the canary. A quantitative Golgi study. J Comp Neurol 1981; 196: 309–16.CrossRefGoogle ScholarPubMed
5.Breedlove, SM, Arnold, AP. Sexually dimorphic motor nucleus in the rat lumbar spinal cord. Brain Res 1981; 225: 297–307.CrossRefGoogle ScholarPubMed
6.Breedlove, SM, Arnold, AP. Hormonal control of a developing neuromuscular system. I. Complete demasculinisation. II. Sensitive periods. J Neurosci 1983; 3: 417–32.CrossRefGoogle Scholar
7.Nordeen, EJ, Nordeen, KW, Sengelaub, D, Arnold, AP. Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus. Science 1985; 229: 671–73.CrossRefGoogle Scholar
8.Kurz, EM, Sengelaub, DR, Arnold, AP. Androgens regulate the dendritic length of mammalian motoneurones in adulthood. Science 1986; 232: 395–98.CrossRefGoogle ScholarPubMed
9.Henry, JL, Calaresu, FR. Topography and numerical distribution of neurones in the thoraco-lumbar intermediolateral nucleus in the cat. J Comp Neurol 1972; 144: 205–14.CrossRefGoogle ScholarPubMed
10.Suzuki, Y, Ishii, H, Furuya, H, Arai, Y. Developmental changes of the hypogastric ganglion associated with the differentiation of reproductive tracts in the mouse. Neurosi Lett 1982; 32: 271–76.CrossRefGoogle ScholarPubMed
11.Wright, LL, Smolen, AJ. Neonatal testosterone treatment increases neuron and synapse numbers in male rat superior cervical ganglion. Devel Brain Res 1983; 8: 145–53; 1985; 20: 311–16.CrossRefGoogle Scholar
12.Melvin, JE, McNeill, TH, Hervonen, A, Hamill, RW. Organisational role of testosterone in hypogastric ganglion perinatal development. Brain Res 1989; 485: 1-10 et 11–19.CrossRefGoogle Scholar
13.Dörner, G, Staudt, J. Structural changes in the preoptic anterior hypothalamic area of the male rat, following neonatal castration and androgen substitution. Neuroendocrinology 1968; 3: 136–40.CrossRefGoogle ScholarPubMed
14.Dörner, G, Staudt, J. Structural changes in the hypothalamic ventromedial nucleus of the male rat, following neonatal castration and androgen treatment. Neuroendocrinology 1969; 4: 278–81.CrossRefGoogle ScholarPubMed
15.Booth, JE. Evidence for separate masculinisation and defeminisation of the brain during development of male rats. J Physiol 1979; 289: 53P. Barton AC, Demarest KT, Lookingland KJ, Moore KE. A sex difference in the stimulatory afferent regulation of tubero-infundibular dopaminergic neuronal activity. Neuroendocrinology 1989; 49: 361–66Google Scholar
16.Gorski, R, Gordon, J, Shryne, J, Southam, A. Evidence for a morphological sex difference within the medial pre-optic area of the rat brain. Brain Res 1978; 148: 33–46.CrossRefGoogle Scholar
17.Olsen, KL, Edwards, E, Schecter, N, Whalen, RE. Muscarinic receptors in pre-optic area and hypothalamus: effects of cyclicity, sex and estrogen treatment. Brain Res 1988; 448: 223–29.CrossRefGoogle Scholar
18.Diamond, MC. Enriching heredity. New York: The Free Press, 1988.Google Scholar
19.Diamond, MC. Sex and the cerebral cortex. Biolog Psychiatry 1989; 25: 823–25.CrossRefGoogle ScholarPubMed
20.Dörner, G, Staudt, J. Vergleichende Morphologische Untersuchungen der Hypothalamusdifferenzierung bei Ratte und Mensch. Endocrinologie 1972; 59: 152–55.Google Scholar
21.Swaab, DF, Fliers, E. A sexually dimorphic nucleus in the human brain. Science 1985; 228: 112–15.CrossRefGoogle ScholarPubMed
22.Ehrhardt, AA, Meyer-Bahlburg, HFL. Effects of prenatal sex hormones on gender-related behaviour. Science 1981; 221: 1312–18. [One of nine articles in the 20 March issue devoted to sexual dimorphism: Naftolin F, Butz E, eds. Science 1981; 221: 1263–1324.]CrossRefGoogle Scholar
23.Van der Werff ten Bosch, JJ, Van der Schoot, P. Sex differences in the central nervous system. Endeavour, New Series 1987; 11: 156–58.CrossRefGoogle ScholarPubMed
24.Blom, JL. Is there a difference in male and female brain activity? J Physiol 1985; 366: 18P.Google Scholar
25.De Lacoste-Ultamsing, C, Holloway, RL. Sexual dimorphism in the human corpus callosum. Science 1982; 216: 1431–32.CrossRefGoogle Scholar
26.Kertesz, A, Polk, M, Howell, J, Black, SE. Cerebral dominance, sex, and callosal size in MRI. Neurology 1987; 37: 1385–88.CrossRefGoogle ScholarPubMed
27.Clarke, S, Kraftsik, R, Van der Loss, H, Innocenti, GM. Forms and measures of adult and developing human corpus callosum: is there sexual dimorphism? J Comp Neurol 1989; 280: 213–30.CrossRefGoogle ScholarPubMed
28.Hyde, JS, Linn, MC. Gender differences in verbal ability: a meta-analysis. Psychol Bulletin 1988; 104: 53–69.CrossRefGoogle Scholar
29.Wachter, KW. Disturbed by meta-analysis? Science 1988; 241: 1407–08.CrossRefGoogle ScholarPubMed
30.Hahn, WK, Cerebral lateralisation of function. From infancy through childhood. Psychol Bulletin 1987; 101: 376–92.CrossRefGoogle ScholarPubMed
31.Kimura, D. Sex differences in intra-hemispheric organisation of speech. Behav Brain Sci 1980; 3: 240–41.CrossRefGoogle Scholar
32.Kimura, D. Sex differences in cerebral organisation for speech and praxic functions. Canad J Psychol 1983; 37: 19–35; 1987; 28: 133–47.CrossRefGoogle ScholarPubMed
33.Lewis, RS, Christiansen, L. Intrahemispheric sex differences in the functional representation of language and praxic functions in normal individuals. Brain and Cognition 1989; 9: 238–43.CrossRefGoogle ScholarPubMed
34.Caplan, PJ, MacPherson, GM, Tobin, P. Do sex-related differenees in spatial abilities exist? Amer Psychologist 1985; 40: 786–99.CrossRefGoogle Scholar
35.Velle, W. Sex differences in sensory functions. Persp Biol Med 1987; 30: 490–522.CrossRefGoogle ScholarPubMed
36.Levy, J. Cerebral asymmetry and the psychology of man. In: Wittock, MC, ed. The brain and psychology. New York: Academic Press, 1980. Burton LA. Sex differences in the lateralized processing of facial emotion. Brain and Cognition 1989; 11: 210–228.Google Scholar
37.Benbow, CP. Sex differences in mathematical reasoning ability in intellectually talented preadolescents: their nature, effects and possible causes. Behav Brain Sci 1988; 11: 169–232.CrossRefGoogle Scholar
38.Schaal, B. Olfaction in infants and children: development and functional properties. Chem Senses 1988; 13: 145–90.CrossRefGoogle Scholar
39.Orty, RL. Endocrine influences upon human olfactory function. Neural control of reproductive function 1988; 50: 567–82.Google Scholar
40.Good, PR, Geary, N, Engen, T. The effect of estrogen on odor detection. Chem Senses 1976; 2: 45–50.CrossRefGoogle Scholar
41.White, DF, Douglas, NJ, Pickett, CK, Weil, JV, Zwillich, CW, Sexual influence on the control of breathing. J Appl Physiol 1983; 54: 874–79.CrossRefGoogle ScholarPubMed
42.Kelly, DB. Sexually dimophic behaviours. Annu Rev Neurosci 1988; 11: 225–51.CrossRefGoogle Scholar
43.Arnold, AP, Jordon, CL. Hormonal orgainsation of neural circuits. Frontiers in neuroendocrinology 1988; 10: 185–214.Google Scholar