Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-24T03:47:41.845Z Has data issue: false hasContentIssue false
  • English
  • Français

Obsessive compulsive disorder and multiple sclerosis: a case report implicating serotonergic dysfunction

Published online by Cambridge University Press:  13 June 2014

Aideen Freyne  and
Rory K Shelley
Aideen Freyne
Affiliation:
James Connolly Memorial Hospital, Blanchardstown, Dublin 15, Ireland
Rory K Shelley
Affiliation:
St. John of God Hospital, Stillorgan, Co. Dublin, Ireland
Get access Rights & Permissions [Opens in a new window]

Abstract

A patient who developed obsessive compulsive disorder within a year of developing multiple sclerosis is described. Possible reasons for an association between these two conditions are discussed. The role of serotonergic pathway dysfunction in obsessive compulsive disorder is also suggested by the pharmacological response in this case.

Keywords

Obsessive compulsive disorderMultiple sclerosisSerotonergic dysfunction.
Type
Clinical and Brief Reports
Information
Irish Journal of Psychological Medicine , Volume 11 , Issue 1 , March 1994 , pp. 26 - 27
Copyright
Copyright © Cambridge University Press 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Kettl, PA, Marks, IM. Neurological factors in obsessive compulsive disorder: two case reports and a review of the Literature. Br J Psychiatry 1986; 149: 315–9.CrossRefGoogle Scholar
2.McKeown, J, McGuffin, P, Robinson, P. Obsessive compulsive neurosis following head injury – a report of four cases. Br J Psychiatry 1984; 144: 190–2.CrossRefGoogle Scholar
3.George, MS, Kellner, CH, Fossey, MD. Obsessive compulsive symptoms in a patient with Multiple Sclerosis. J Nerv Ment Dis 1989; 177: 304–5.CrossRefGoogle Scholar
4.Swedo, SE, Rapoport, JL, Cheslow, DL, et al.High prevalence of obsessive compulsive symptoms in patients with Sydenham's chorea. Am J Psychiatry 1989; 146: 246–9.Google ScholarPubMed
5.Swedo, SE, Leonard, HL, Rapoport, JL, et al.A double blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling). New Eng J Med 1989; 321: 497–501.CrossRefGoogle ScholarPubMed
6.Goodman, WK, Price, LH, Rasmussen, SA, et al.Efficacy of fluvoxamine in obsessive compulsive disorder: a double blind comparison with placebo. Arch Gen Psychiatry 1989; 46: 36–44.CrossRefGoogle ScholarPubMed
7.Levine, R, Hoffman, JS, Knepple, ED, et al.Long term fluoxetine treatment of a large number of obsessive compulsive patients. J Clin Psychopharm 1989; 9: 281–3.CrossRefGoogle ScholarPubMed
8.McDougle, CJ, Goodman, WK. Obsessive compulsive disorder: recent neurobiological developments. Current Opinion in Psychiatry 1990; 3: 239–44.CrossRefGoogle Scholar
9.Surridge, D. An investigation into some psychiatric aspects of multiple sclerosis. Br J Psychiatry 1969; 115: 749–64.CrossRefGoogle ScholarPubMed
10.McKeown, J, Roa, B, Mann, A. Life events and personality traits in obsessive compulsive neurosis. Br J Psychiatry 1984; 144: 185–9.CrossRefGoogle Scholar
11.Karno, M, Golding, JM, Sorensen, SB, et al.The epidemiology of obsessive compulsive disorder in five U.S. communities. Arch Gen Psychiatry 1988; 45: 1094–9.CrossRefGoogle ScholarPubMed