Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-26T04:12:03.274Z Has data issue: false hasContentIssue false
  • English
  • Français

Hypertension and increased serum clozapine associated with clozapine and fluoxetine in combination

Published online by Cambridge University Press:  13 June 2014

Darina Sloan  and
James O'Boyle
Get access Rights & Permissions [Opens in a new window]

Abstract

We report the case of a patient with schizophrenia who demonstrated increased serum clozapine and norclozapine levels in association with hypertension, when treated with fluoxetine and clozapine in combination.

Keywords

ClozapineFluoxetineCytochrome P450 2D6HypertensionDrug interaction
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 14 , Issue 4 , December 1997 , pp. 151 - 152
Copyright
Copyright © Cambridge University Press 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Kane, J, Honigfelt, G, Singer, Jet al.Clozapine for the treatment-resistant schizophrenic. Arch Gen Psych 1988; 45: 789–96.CrossRefGoogle ScholarPubMed
2.Goff, DC, Brotman, AW, Waites, M, Mc Cormack, S.Trial of fluoxetine added to neuroleptics for treatment resistant schizophrenic patients. Am J Psychiatry 1990; 147: 492–4.Google ScholarPubMed
3.Spina, E, De Domenico, P, Ruello, Cet al.Adjunctive fluoxetine in the treatment of negative symptoms in chronic schizophrenic patients. Int Clin Psychopharmacol 1994; 9: 281–5.CrossRefGoogle ScholarPubMed
4.Cassady, SL, Thaker, GK. Addition of clozapine to fluoxetine [Letter]. Am J Psychiatry 1992; 149: 1274Google ScholarPubMed
5.Patel, B, Tandon, R. Development of obsessive-compulsive symptoms during clozapine treatment. Am J Psychiatry 1993; 150: 836.Google ScholarPubMed
6.Perry, PJ, Miller, D, Arndts, , et al.Clozapine and norclozapine plasma concentrations and clinical response of treatment refractory schizophrenic patients. Am J Psychiatry 1991; 148: 231–5.Google ScholarPubMed
7.Centorrino, F, Baldessarini, RJ, Kando, JCet al.Clozapine and metabolites: Concentrations in serum and clinical findings during treatment of chronically psychotic patients. J Clin Psychopharmacol 1994; 14: 119–25.CrossRefGoogle ScholarPubMed
8.Kingsbury, SJ, Puckett, KM. Serum concentrations of clozpine and its major metabolites: effects of cotreatment with fluoxetine or valproate: comment. Am J Psychiatry 1995; 152: 473.CrossRefGoogle Scholar
9.Cassady, SL, Thaker, GK. Addition of clozapine to fluoxetine (Letter). Am J psychiatry 1992; 149: 1274.Google Scholar
10.Patel, B, Tandon, R. Development of obsessive-compulsive symptoms during clozapine treatment. Am J Psychiatry 1993; 150: 836.Google ScholarPubMed