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Deterioration in renal function following commencement of citalopram

Published online by Cambridge University Press:  13 June 2014

Neil Mayfield ,
Kay Anderson  and
Colin Rodger
Neil Mayfield
Affiliation:
Royal Edinburgh Hospital, Edinburgh
Kay Anderson
Affiliation:
Royal Victoria Hospital, Edinburgh
Colin Rodger
Affiliation:
Herdmanflat Hospital, Haddington, East Lothian, England
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Abstract

We report the case of an 85 year old woman, admitted to hospital with a two month history of a depressive illness. Within one week of commencing treatment with citalopram 20mg daily, she had developed a widespread rash, bilateral ankle oedema and a range of biochemical and haematological abnormalities, including marked elevations of plasma urea and creatinine and increased neutrophil and eosinophil counts. Following withdrawal of citalopram, her physical state returned to normal within two weeks. The episode is suggestive of acute interstitial nephritis triggered by citalopram, a phenomenon not previously reported in association with the selective serotonin reuptake inhibitors.

Type
Case report
Information
Irish Journal of Psychological Medicine , Volume 20 , Issue 1 , March 2003 , pp. 32 - 33
Copyright
Copyright © Cambridge University Press 2000

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