The international pilot study of schizophrenia (IPSS) was the first major study to show that the use of standardised assessment and classification instruments allows the reliable comparison of data on the prevalence, psychopathology and prognosis of major psychiatric illness between different cultures. Important questions about the methodology used in cross-cultural research remain to be answered, however These include the inherently ‘Eurocentric’ nature of much of western psychiatric terminology and the absence of directly comparable concepts and language to describe emotional and psychological distress between western and non-western cultures. These difficulties especially arise in relation to illness where organic factors appear to contribute little to aetiology, such as the neurotic and Axis II disorders, and need to be overcome before useful crosscultural research into these disorders can be accomplished.