Hostname: page-component-669899f699-chc8l Total loading time: 0 Render date: 2025-04-24T11:10:19.207Z Has data issue: false hasContentIssue false
  • English
  • Français

Complications of verapamil in psychiatry

Published online by Cambridge University Press:  13 June 2014

Kenneth R Kaufman
Kenneth R Kaufman*
Affiliation:
Department of Psychiatry, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey, 08901, USA
Get access Rights & Permissions [Opens in a new window]

Abstract

Effectiveness of verapamil as a psychotropic and verapamil toxicity when used as a psychotropic are presented in this case study with literature review.

Keywords

Affective disordersVerapamilToxicityCimetidine
Type
Brief Reports
Information
Irish Journal of Psychological Medicine , Volume 13 , Issue 3 , September 1996 , pp. 100 - 101
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1.Post, RM. Approaches to treatment-resistant bipolar affectively ill patients. Clin Neuropharm 1988; 11(2): 93–104.CrossRefGoogle ScholarPubMed
2.Gerner, RM. Treatment of acute mania. Psychiatric Clinics of North America 1993; 16(3): 443–60.CrossRefGoogle ScholarPubMed
3.Post, RM, Uhde, TW, Roy-Byrne, PP, Joffe, RT. Correlates of antimanic response to carbamazepine. Psychiat Res 1987; 21: 71–83.CrossRefGoogle ScholarPubMed
4.McElroy, SL, Keck, PE, Pope, HG, Hudson, JI. Valproate in the treatment of bipolar disorder: literature review and clinical guidelines. J of Clin Psychopharm 1992; 12:42S–52S.CrossRefGoogle ScholarPubMed
5.Chouinard, G, Young, SN, Annable, L. Antimanic effects of clonazepam. Biol Psychiat 1983; 18:451–66.Google ScholarPubMed
6.Dubovsky, SL. Calcium antagonists in manic-depressive illness. Neuropsychobiology 1993; 27: 184–92.CrossRefGoogle ScholarPubMed
7.Carman, JS, Wyatt, RJ. Calcium: bivalent cation in the bivalent psychoses. Biol Psychiat 1979; 14: 295–336.Google ScholarPubMed
8.Mathis, P, Schmitt, L, Moron, P. Efficacite du verapamil dans les acces maniaques. L'Encephale 1988; XIV: 127–32.Google Scholar
9.Dubovsky, SL, Murphy, J, Christiano, J, Lee, C. The calcium second messenger system in bipolar disorders: data supporting new research directions. J of Neuropsychiat and Clin Neurosci 1992; 4: 3–14.Google ScholarPubMed
10.Schou, M, Mellerup, ET, Rafaelsen, OJ. Mode of action of lithium. in Van, Praag HM, Lader, MH, Rafaelsen, OJ, Sachar, EJ, eds. Handbook of biological psychiatry. New York: Marcel Decker, 1981: 805–24.Google Scholar
11.Messing, RO, Carpenter, CL, Greenberg, DA. Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists. J of Pharm and Exp Ther 1985; 235: 407–11.Google ScholarPubMed
12.Crowder, JM, Bradford, HF. Common anticonvulsants inhibit Ca2+ uptake and amino acid neurotransmitter release in vitro. Epilepsia 1987; 28(4): 378–82.CrossRefGoogle ScholarPubMed
13.Taft, WC, Goldenring, JR, DeLorenzo, RJ. Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity. in Ehrlich, YH, Lenox, RH, Kornecki, E, Berry, WO, eds. Molecular mechanisms of neuronal responsiveness. New York: Plenum, 1987: 409–24.CrossRefGoogle Scholar
14.Franceschetti, S, Hamon, B, Heinemann, U. The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]o and [K+]o in the hippocampal slice. Brain Res 1986; 386: 1–11.CrossRefGoogle Scholar
15.Taft, WC, DeLorenzo, RJ. Micromolar-affinity benzodiazepine receptors regulate voltage sensitive calcium channels in nerve terminal preparations. Proc Nat Acad of Sci 1984; 81(10): 3118–22.CrossRefGoogle ScholarPubMed
16.Matlib, MA, Doane, JD, Sperelakis, N, Riccippo-Neto, F. Clonazepam and diltiazem both inhibit sodium-calcium exchange of mitochondria, but only diltiazem inhibits the slow action potentials of cardiac muscles. Biochem and Biophys Res Comm 1985; 128: 290–6.CrossRefGoogle ScholarPubMed
17.Drago, F, Valeris, C, Clementi, G, Scapagnini, U. Effects of flunarizine on experimentally induced convulsions in animals. Fun Neur 1986; 1(4): 529–32.Google ScholarPubMed
18.Ots, ME, Yaksh, TL, Anderson, RE, Sundt, TM. Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats. J of Neurosurg 1987; 67(3): 406–13.CrossRefGoogle ScholarPubMed
19.Larkin, JG, McKee, PJW, Blacklaw, J, Thompson, GG, Morgan, PC, Brodie, MJ. Nimodipine in refractory epilepsy: a placebo-controlled, add-on study. Epilepsy Res 1991;9:71–7.CrossRefGoogle ScholarPubMed
20.Xie, JT, Li, CL. Induction and termination of after-depolarisations and triggered arrhythmias by drugs in cat heart in vivo. Meth and Find in Exp and Clin Pharm 1992; 14(5): 347–54.Google Scholar
21.Meerson, FZ, Gimrikh, EO, Gutsol, LI, Popov, SV, Plekhanov, IG. The antiarrhythmic efficacy of sodium valproate. Kardiologiya 1992; 32: 19–21.Google ScholarPubMed
22.Pazzaglia, PJ, Post, RM, Ketter, TA, George, MS, Marangell, LB. Preliminary controlled trial of nimodipine in ultra-rapid cycling affective dysregulation. Psychiat Res 1993; 49: 257–72.CrossRefGoogle ScholarPubMed
23.Mikus, G, Eichelbaum, M, Fischer, C, Gumulka, S, Klotz, U, Kroemer, HK. Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action. J of Pharm and Exp Ther 1990; 253(3): 1042–8.Google ScholarPubMed
24.Rosansky, SJ. Verapamil toxicity – treatment with hemoperfusion. Ann of Intern Med 1991; 114(4): 340–1.CrossRefGoogle ScholarPubMed