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Clozapine-induced interstitial nephritis in a patient with schizoaffective disorder in the forensic setting: a case report and review of the literature

Published online by Cambridge University Press:  21 June 2019

C. McLoughlin ,
C. Cooney  and
R. Mullaney
C. McLoughlin*
Affiliation:
Tallaght University Hospital, Belgard Square North, Dublin 24, Ireland
C. Cooney
Affiliation:
Central Mental Hospital, Dundrum, Dublin 14, Ireland
R. Mullaney
Affiliation:
Central Mental Hospital, Dundrum, Dublin 14, Ireland
*
*Address for correspondence: Dr Caoimhe McLoughlin, Tallaght University Hospital, Belgard Dublin 24, Ireland (Email: [email protected])
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Abstract

We present a rare case of Acute Interstitial Nephritis (AIN) that occurred following a re-trial of clozapine in a 56-year-old lady with schizoaffective disorder. On initial trial of clozapine, this patient felt generally unwell with respiratory symptoms. Her inflammatory markers were raised and her renal function showed a mild, transient deterioration which normalised on the day of cessation of clozapine. Two years later, clozapine was re-trialled due the refractory nature of her psychiatric symptoms. She subsequently developed renal failure and AIN was confirmed by renal biopsy. Renal function improved after cessation of clozapine; however, she never fully regained normal renal function.

Keywords

Clozapine/adverse effectsinterstitial nephritisrenal failure
Type
Case Report
Information
Irish Journal of Psychological Medicine , Volume 39 , Issue 1 , March 2022 , pp. 106 - 111
Copyright
© The Author(s), 2019. Published by Cambridge University Press on behalf of The College of Psychiatrists of Ireland

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