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Blood groups in dementia (SDAT) — a pilot study

Published online by Cambridge University Press:  13 June 2014

V M Mathew
V M Mathew*
Affiliation:
Department of Psychiatry, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, England
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Abstract

Objective: Various studies have shown an association between ABO blood groups and both physical and mental illness. This pilot study was conducted to find out whether there is any association between ABO blood groups and senile dementia of Alzheimer's type. Methods: The sample was selected from 107 patients admitted to the psychogeriatric assessment unit of the district psychiatric hospital over a period of one year. All Caucasian patients of United Kingdom origin above the age of 70 with confirmed diagnosis of Alzheimer's dementia according to DSM-III criteria who had developed dementia after the age of 65 were included (N = 33); 74 patients were excluded for various reasons. Results: Out of the 33 patients there were 21 (64%) with group A, 3 (9%) with group B, 9 (27%) with group O and none with group AB blood. Among the United Kingdom population there were 79,334 (42%) with group A, 16,280 (9%) with group B, 88,782 (47%) with group O and 5,781 (3%) with group AB blood (p = 0.038). Conclusions: Although the number of cases were not large, the results of this study suggest that the prevalence of type A blood group was greater and O was less for Caucasian Alzheimer's subjects than for the general population.

Keywords

DementiaBlood groups
Type
Clinical & Brief Reports
Information
Irish Journal of Psychological Medicine , Volume 10 , Issue 2 , June 1993 , pp. 96 - 97
Copyright
Copyright © Cambridge University Press 1993

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References

1.Aird, I, Bentall, HH, Mehigan, JA, Roberts, JAF. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum and bronchus; an association between the ABO groups and peptic ulceration. BMJ 1954; 315–21.CrossRefGoogle ScholarPubMed
2.Parker, JB, Theilie, A, Spielberger, CD. Frequency of blood type in a homogeneous group of manic-depressive patients. Journal of Mental Sciences 1961; 107: 936–2.CrossRefGoogle Scholar
3.Masters, AB. The distribution of blood groups in psychiatric illness. Br J Psychiatry 1967; 113: 1309–15.CrossRefGoogle Scholar
4.Irvine, DG, Miyashita, H. Blood types in relation to depressions and schizophrenia. Can Med Assoc J 1965; 92: 551–4.Google ScholarPubMed
5.Rinieris, PM, Stefanis, CN, Rabavilas, AD, Vaidakis, NM. Obsessive-compulsive neurosis, anancastic symptomatology and ABO blood types. Acta Psychiatr Scand 1978; 57: 377–81.CrossRefGoogle ScholarPubMed
6.Lafferty, CR, Knox, WJ, Malone, MC. Schizophrenia in relation to blood groups ABO and blood types Rh.D and MN. Am J Psychiatry 1957; 133: 1117.CrossRefGoogle Scholar
7.Czechowicz, AS, Pamnany, L. ABO blood groups and the aetiology of schizophrenia. Med J Aust 1972; 1: 1252–4.CrossRefGoogle ScholarPubMed
8.Nardmo, SH. Blood groups in schizophrenia, alcoholism, and mental deficiency. Am J Psychiatry 1959; 116: 460–1.CrossRefGoogle Scholar
9.Schimke, RN, Ziegler, DK. ABO blood groups and Huntington's chorea. Lancet 1970; 2: 475.CrossRefGoogle Scholar
10.Roberts, JAF, Pembrey, ME. An introduction to medical genetics. 8th ed. Oxford: Oxford University Press, 1985: 135.Google Scholar
11.Goate, AM, Owen, MJ, James, LA, et al.Predisposing locus of Alzheimer's disease on chromosome 21. Lancet 1989; 1: 352–5.CrossRefGoogle ScholarPubMed
12.Heston, LJ, Mastri, AR, Anderson, VE, White, J. Dementia of the Alzheimer type: clinical genetics, natural history and associated conditions. Arch Gen Psychiatry 1981; 38: 1085–90.CrossRefGoogle ScholarPubMed
13.Haberland, C. Alzheimer's disease in Down's syndrome. Acta Neurol Belg 1969; 69: 369–80.Google Scholar
14.Whalley, LJ. Dementia of Down's syndrome and its relevance to aetiological studies of Alzheimer's disease. Ann N Y Acad Sci 1982; 369: 39–53.CrossRefGoogle Scholar
15.Wisniewski, KE, Wisniewski, HM, Wen, GY. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 1985; 17 (3): 278–82.CrossRefGoogle ScholarPubMed
16.St George Hyslop, PH, Haines, JL, Farrer, LA, Polinsky, R, Van Broeckhoven, C, Goate, A, et al.Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature 1990; 347: 194–7.CrossRefGoogle Scholar
17.Dobson, AM, Ikin, EW. The ABO blood groups in the United Kingdom; frequencies based on a very large sample. Journal of Pathology and Bacteriology 1946; 48: 221–77.CrossRefGoogle Scholar