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Bipolar affective disorder: advances in genetics and mood-stabilising medication

Published online by Cambridge University Press:  13 June 2014

Daniel C. White
Affiliation:
Department of Adult Psychiatry, University College Dublin, Mater Misericordiae University Hospital, 62/63 Eccles Street, Dublin 7, Ireland
Brendan D. Kelly
Affiliation:
Department of Adult Psychiatry, University College Dublin, Mater Misericordiae University Hospital, 62/63 Eccles Street, Dublin 7, Ireland

Abstract

The lifetime prevalence of bipolar affective disorder is between 1 % and 2%. This educational review paper focuses on two areas of interest and relevance to trainees preparing for the membership examination of the Royal College of Psychiatrists: (a) advances in the genetics of bipolar affective disorder; and (b) mood-stabilising medication in bipolar affective disorder.

Type
Educational Review
Copyright
Copyright © Cambridge University Press 2006

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References

1.Kelly, BD. Investing in the future. Ir J Psychol Med 2004; 21: 111CrossRefGoogle ScholarPubMed
2.Bebbington, P, Ramana, R. The epidemiology of bipolar affective disorder. Social Psychiatry and Psychiatric Epidemiology 1995; 30: 279292CrossRefGoogle ScholarPubMed
3.Craddock, N, Jones, I. The genetics of bipolar disorder. J Medical Genetics 1999; 36: 585594CrossRefGoogle ScholarPubMed
4.McGuffin, P, Katz, R. Nature, nurture and affective disorders. In: The Biology of Depression (ed Deakin, JWK). Gaskell Press, London, 1986Google Scholar
5.Craddock, N, Jones, I. Molecular genetics of bipolar disorder. British Journal of Psychiatry 2001; 41 (suppl):128133CrossRefGoogle ScholarPubMed
6.McGuffin, P, Katz, R. The genetics of depression and manic-depressive disorder. British Journal of Psychiatry, 1989; 155: 294304CrossRefGoogle ScholarPubMed
7.Cardno, AG, Marshall, EJ, Coid, B, Macdonald, AM, Ribchester, TR, Davies, NJ, Venturi, P, Jones, LA, Lewis, SW, Sham, PC, Gottesman, II, Farmer, AE, McGuffin, P, Reveley, AM, Murra, RM. Heritability estimates for psychotic disorders: the Maudsley twin psychosis series. Archives of General Psychiatry 1999; 56: 162168CrossRefGoogle ScholarPubMed
8.Kringlen, E. Heredity and Environment in the Functional Psychoses. London: Heinemann, 1967Google Scholar
9.Allen, MG, Cohen, S, Pollin, W, Greenspan, SI. Affective illness in veteran twins: a diagnostic review. American Journal of Psychiatry 1974; 131:12341239Google ScholarPubMed
10.Bertelsen, A, Harvald, B, Hauge, M. A Danish twin study of manic-depressive disorders. British Journal of Psychiatry 1977; 130 330331CrossRefGoogle ScholarPubMed
11.Torgersen, S. Genetic factors in moderately severe and mild affective disorders. Archives of General Psychiatry 1966; 43: 222226CrossRefGoogle Scholar
12.Kendler, KS, Neale, M, Kessler, R, Heath, A, Eaves, L. A twin study of recent life events and difficulties. Archives of General Psychiatry 1993; 50: 789796CrossRefGoogle ScholarPubMed
13.Mendelwicz, J, Rainer, JD. Adoption study supporting genetic transmission in manic-depressive illness. Nature 1977; 268: 327329CrossRefGoogle Scholar
14.Wender, PH, Kety, SS, Rosenthal, D, Schulsinger, F, Ortmann, J, Lunde, I. Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Archives of General Psychiatry 1986; 43: 923929CrossRefGoogle ScholarPubMed
15.Berrettini, WH. Molecular linkage studies of bipolar disorders. Bipolar Disorders 2001;3:276283CrossRefGoogle ScholarPubMed
16.Blackwood, DH, Fordyce, A, Walker, MT, St Clair, DM, Porteous, DJ, Muir, WJ. Schizophrenia and affective disorders — cosegregation with a translocation at chromosome 1q42 that directly disturbs brain-expressed genes: clinical and P300 findings in a family. American Journal of Human Genetics 2001; 69: 428433CrossRefGoogle Scholar
17.Craddock, N, Owen, M, Burge, S, Kurian, B, Thomas, P, McGuffin, P. Familial co-segregation of major affective disorder and Darier's disease (keratosis follicularis). British Journal of Psychiatry 1994; 164: 355358CrossRefGoogle Scholar
18.Burge, SM, Wilkinson, JD. Darier-White disease: a review of the clinical features in 163 patients. Journal of the American Academy of Dermatology 1999; 27: 4050CrossRefGoogle Scholar
19.Craddock, N, Dawson, E, Burge, S, Parfitt, L, Mant, B, Roberts, O, Daniels, J, Gill, M, McGuffin, P, Powell, J. The gene for Darier's disease maps to chromosome 12q23-q24.1. Human Molecular Genetics 1993; 2: 19411943CrossRefGoogle ScholarPubMed
20.Ewald, H, Degn, B, Mors, O, Kruse, TA. Significant linkage between bipolar affective disorder and chromosome 12q24. Psychiatric Genetics 1998; 8: 131140CrossRefGoogle ScholarPubMed
21.Jones, I, Owen, MJ, Craddock, N. Further evidence of familial cosegregation of major affective disorder and Darier's disease. Molecular Psychiatry 1999; 4: S73Google Scholar
22.Jacobsen, N, Daniels, J, Moorhead, S, Harrison, D, Feldman, E, McGuffin, P, Owen, MJ, Craddock, N. Association study of biplar disorder at the phospholipase A2 gene (PLA2A) in the Darier's disease (DAR) region of chromosome 12q23-q24.1. Psychiatric Genetics 1997; 6: 195199CrossRefGoogle Scholar
23.Franks, E, Guy, C, Jacobsen, N, Bowen, T, Owen, MJ, O'Donovan, MC, Craddock, N. Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder. American Journal of Medical Genetics (Neuropsychiatric Genetics) 1999; 88: 67703.0.CO;2-#>CrossRefGoogle ScholarPubMed
24.Sakuntabhai, A, Ruiz-Perez, V, Carter, S, Jacobsen, N, Burge, S, Monk, S, Smith, M, Munro, CS, O'Donovan, M, Craddock, N, Kucheriapati, R, Rees, JL, Owen, M, Lathrop, GM, Monaco, AP, Strachan, T, Hovnanian, A. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier's disease. Nature Genetics 1999; 21: 271277CrossRefGoogle Scholar
25.Jacobsen, N, Lyons, I, Hoogendoorn, B, Burge, S, Kwok, PY, O'Donovan, MC, Craddock, N, Owen, MJ. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 1999; 8: 16311636CrossRefGoogle ScholarPubMed
26.Plomin, R, Owen, MJ, McGuffin, P. The genetic basis of complex human behaviours. Science 1994; 26: 17331739CrossRefGoogle Scholar
27.Jones, I, Craddock, N. Candidate gene studies of bipolar disorder. Annals of Medicine 2001;33:248256CrossRefGoogle ScholarPubMed
28.Lachman, HM, Morrow, B, Shprintzen, R, Veit, S, Parsia, SS, Faedda, G, Goldberg, R, Kurcherlapati, R, Papolos, PF. Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. American Journal of Medical Genetics (Neuropsychiatric Genetics) 1996; 67: 4684723.0.CO;2-G>CrossRefGoogle ScholarPubMed
29.Kirov, G, Murphy, KC, Arranz, MJ, Jones, I, McCandles, F, Kunugi, H, Murray, RM, McGuffin, P, Collier, DA, Owen, MJ, Craddock, N. Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder. Molecular Psychiatry 1998; 3: 342345CrossRefGoogle ScholarPubMed
30.Coyle, N, Jones, I, Robertson, E, Lendon, C, Craddock, N. Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis. Lancet 2000; 356: 14901491CrossRefGoogle ScholarPubMed
31.Goossens, D, Del-Favero, J, Van Broeckhoven, C. Trinucleotide repeat expansions: do they contribute to bipolar disorder? Brain Research Bulletin 2001; 56: 243257CrossRefGoogle ScholarPubMed
32.Kato, T. Molecular genetics of bipolar disorder. Neuroscience Research 2001; 4: 105113CrossRefGoogle Scholar
33.Bramon, E, Sham, PC. The common genetic liability between schizophrenia and bipolar disorder: a review. Current Psychiatry Reports 2001; 3: 332337CrossRefGoogle ScholarPubMed
34.Cardno, AG, Rijsdijk, FV, Sham, PC, Murray, RM, McGuffin, P. A twin study of genetic relationships between psychotic symptoms. American Journal of Psychiatry 2002; 159: 539545CrossRefGoogle ScholarPubMed
35.Portin, P, Alanen, YO. A critical review of genetic studies of schizophrenia. II. Molecular genetic studies. Acta Psychiatrica Scandinavica 1997; 95: 7380CrossRefGoogle ScholarPubMed
36.Berrettini, WH. Are schizophrenic and bipolar disorders related? A review of family and molecular studies. Biological Psychiatry 2000; 48: 531538CrossRefGoogle ScholarPubMed
37.Kelly, BD. Schizophrenia: update on genetic, cognitive behavioural therapy and early intervention. Irish Journal of Psychological Medicine 2005; 22: 6266CrossRefGoogle ScholarPubMed
38.Johnstone, EC, Cooling, NJ, Frith, CD, Crow, TJ, Owens, DG. Phenomenology of organic and functional psychoses and the overlap between them. British Journal of Psychiatry 1988; 153: 770776CrossRefGoogle ScholarPubMed
39.Tanenberg-Karant, M, Fennig, S, Ram, R, Krishna, J, Jandorf, L, Bromet, EJ. Bizarre delusions and first rank symptoms in a first-admission sample: a preliminary analysis of prevalence and correlates. Comprehensive Psychiatry 1995; 36: 428434CrossRefGoogle Scholar
40.Post, RM. Comparative pharmacology of bipolar disorder and schizophrenia. Schizophrenia Research 1999; 39: 153158CrossRefGoogle ScholarPubMed
41.Benabarre, A, Vieta, E, Colom, F, Martinez-Aran, A, Reinares, M, Gasto, C. Bipolar disorder, schizoaffective disorder and schizophrenia: epidemiologic, clinical and prognostic differences. European Psychiatry 2001; 16: 167172CrossRefGoogle ScholarPubMed
42.Baumann, B, Bogerts, B. The pathomorphology of schizophrenia and mood disorders: similarities and differences. Schizophrenia Research 1999; 39: 141148CrossRefGoogle ScholarPubMed
43.Cotter, D, Pariante, CM. Stress and the progression of the developmental hypothesis of schizophrenia. British Journal of Psychiatry 2002; 181: 363365CrossRefGoogle ScholarPubMed
44.Chou, JC. Recent advances in treatment of acute mania. Journal of Clinical Psychopharmacology 1991; 11: 321Google ScholarPubMed
45.Ferrier, IN, Tyrer, SP, Bell, AJ. Lithium therapy. Advances in Psychiatric Treatment 1995; 1: 102110.CrossRefGoogle Scholar
46.Burgess, S, Geddes, J, Hawton, K, Townsend, E, Jamison, K, Goodwin, G. Lithium for maintenance treatment of mood disorders. Cochrane Database Systematic Reviews 2001;3:CD003013Google Scholar
47.Suppes, T, Baldessarini, RJ, Faedda, Gl, Tohen, M. Risk of recurrence following discontinuation of lithium treatment in bipolar disorder. Archives of General Psychiatry 1991;48: 10821088CrossRefGoogle ScholarPubMed
48.Yerevanian, Bl, Koek, RJ, Mintz, J, Lithium, anticonvulsants and suicidal behaviour in bipolar disorder. Journal of Affective Disorders 2003; 73: 223228CrossRefGoogle ScholarPubMed
49.Müller-Oerlinghausen, B, Felber, W, Berghofer, A, Lauterbach, E, Ahrens, B. The impact of lithium long-term medication on suicidal behavior and mortality of bipolar patients. Archives of Suicide Research 2005; 9: 307319CrossRefGoogle ScholarPubMed
50.Taylor, D, Paton, C, Kerwin, R. The Maudsley Prescribing Guidelines, 2005-2006 (8th edition). Taylor & Francis, London and New York, 2005CrossRefGoogle Scholar
51.Gelder, M, Gath, D, Mayou, R, Cowen, P. Oxford textbook of Psychiatry (3rd edition). Oxford University Press, Oxford, 1996Google Scholar
52.Guscott, R, Taylor, L. Lithium prophylaxis in recurrent affective illness. Efficacy, effectiveness and efficiency. British Journal of Psychiatry 1994; 164: 741746.CrossRefGoogle ScholarPubMed
53.Cohen, LS, Friedman, JM, Jefferson, JW, Johnson, EM, Weiner, ML. A reevaluation of risk of in utero exposure to lithium. Journal of the American Medical Association 1994; 271: 146150.CrossRefGoogle ScholarPubMed
54.Yonkers, KA, Wisner, KL, Stowe, Z, Leibenluft, E, Cohen, L, Miller, L, Manber, R, Viguera, A, Suppes, T, Altshuler, L. Management of bipolar disorder during pregnancy and the postpartum period. American Journal of Psychiatry 2004; 161: 608620CrossRefGoogle ScholarPubMed
55.Charudon, LH, Jefferson, JW. Mood stabilizers during breastfeeding: a review. Journal of Clinical Psychiatry 2000; 61: 7990Google Scholar
56.Young, RC, Gyulai, L, Mulsant, BH, Flint, A, Beyer, JL, Shulman, Kl, Reynolds, CF 3rd. Pharmacotherapy of bipolar disorder in old age: review and recommendations. American Journal of Geriatric Psychiatry 2004; 12: 342357CrossRefGoogle ScholarPubMed
57.Juurlink, DN, Mamdani, MM, Kopp, A, Rochon, PA, Shulman, Kl, Redelmeier, DA. Drug-induced lithium toxicity in the elderly: a population-based study. Journal of the American Geriatric Society 2004; 52: 794798.CrossRefGoogle ScholarPubMed
58.Rendell, JM, Gijsman, HJ, Keck, P, Goodwin, GM, Geddes, JR. Olanzapine alone or in combination for acute mania. The Cochrane Database of Systematic Reviews 2003, Issuel. Article number: CD004040. DOI 10.1002/14651 858. CD004040CrossRefGoogle Scholar
59.Tohen, M, Greil, W, Calabrese, JR, Sachs, GS, Yatham, LN, Muller Oerlinghausen, B, Koukopoulos, A, Cassano, GB, Grunze, H, Licht, RW, Dell'Osso, L, Evans, AR, Risser, R, Baker, RW, Crane, H, Dossenbach, MR, Bowden, CL. Olanzapine versus lithium in the maintenance treatment of bipolar disorder: A 12 month, randomized, double blind controlled clinical trial. American Journal of Psychiatry 2005; 162: 12811290.CrossRefGoogle ScholarPubMed
60.Keck PE, Jr, Corya, SA, Altshuler, LL, Ketter, TA, McElroy, SL, Case, M, Briggs, SD, Tohen, M. Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression. Journal of Clinical Psychiatry 2005; 66: 611616.CrossRefGoogle ScholarPubMed
61.Tohen, M, Chengappa, KNR, Suppes, Tet al.Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy. Archives of General Psychiatry 2002; 69: 6269CrossRefGoogle Scholar
62.Baker, RW, Brown, E, Akiskal, HS, Calabrese, JR, Ketter, TA, Schuh, LM, Trzepacz, PT, Watkin, JG, Tohen, M. Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania. British Journal of Psychiatry. 2004; 185: 472478CrossRefGoogle ScholarPubMed
63.Calabrese, JR, Bowden, CL, Sachs, GS, Ascher, JA, Monaghan, E, Rudd, GD. A double blind placebo controlled trial of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 study group. Journal of Clinical Psychiatry 1999; 60: 7988.CrossRefGoogle ScholarPubMed
64.Bowden, CL, Mitchell, P, Suppes, T. Lamotrigine in the treatment of bipolar depression. European Neuropsychopharmacology. 1999; 9 (Suppl 4): S113117.CrossRefGoogle ScholarPubMed
65.Goodwin, GM, Bowden, CL, Calabrese, JR, Grunze, H, Kasper, S, White, R, Greene, P, Leadbetter, R. A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. Journal of Clinical Psychiatry 2004; 65: 432441.CrossRefGoogle ScholarPubMed
66.Goldsmith, DR, Wagstaff, AJ, Ibbotson, T, Perry, CM. Lamotrigine: a review of its use in bipolar disorder. Drugs 2003; 63: 20292050.CrossRefGoogle ScholarPubMed
67.Fatemi, SH, Rapport, DJ, Calabrese, JR, Thuras, P. Lamotrigine in rapid-cycling bipolar disorder. Journal of Clinical Psychiatry. 1997; 58: 522527.CrossRefGoogle ScholarPubMed
68.Bowden, CL, Calabrese, JR, McElroy, SL, Rhodes, LJ, Keck PE, Jr, Cookson, J, Anderson, J, Bolden-Watson, C, Ascher, J, Monaghan, E, Zhou, J. The efficacy of lamotrigine in rapid cycling and non-rapid cycling patients with bipolar disorder. Biological Psychiatry. 1999;46:17111712.CrossRefGoogle Scholar
69.Messenheimer, J, Mullens, EL, Giorgi, L, Young, FSafety review of adult clinical trial experience with lamotrigine. Drug Safety. 1998; 18: 281296.CrossRefGoogle ScholarPubMed
70.Keck, PE Jr, McElroy, SL. Divalproex in the treatment of bipolar disorder. Psychopharmacology Bulletin. 2003; 37 (Suppl. 2): 6773.Google ScholarPubMed
71.Freeman, TW, Clothier, JL, Pazzaglia, P, Lesem, MD, Swann, AC. A double-blind comparison of valproate and lithium in the treatment of acute mania. American Journal of Psychiatry 1992; 149: 108111.Google ScholarPubMed
72.Swann, AC, Bowden, CL, Morris, D, Calabrese, JR, Petty, F, Small, J, Dilsaver, SC, Davis, JM. Depression during mania. Treatment response to lithium or divalproex. Archives of General Psychiatry 1997; 54: 3742.CrossRefGoogle ScholarPubMed
73.Macritchie, K, Geddes, JR, Scott, J, Haslam, D, de Lima, M, Goodwin, G. Valproate for acute mood episodes in bipolar disorder. Cochrane Database of Systematic Reviews 2003; 1:CD004052Google Scholar
74.Sachs, G. Managing Bipolar Affective Disorder. London: Science Press Ltd., 2004Google Scholar
75.Rimmer, EM, Richens, A. An update on sodium valproate. Pharmacotherapy. 1985; 5: 171184CrossRefGoogle ScholarPubMed
76.Dardennes, R, Even, C, Bange, F, Heim, A. Comparison of carbamazepine and lithium in the prophylaxis of bipolar disorders. A meta-analysis. The British Journal of Psychiatry 1995; 166:378381.CrossRefGoogle ScholarPubMed
77.Ketter, T, Post, RDenicoff, K. et al.Carbamazepine. Mania. Clinical and Research Perspectives. American Psychiatric Association. 1998: 263300.Google Scholar
78.Barrios, C, Chaudhry, TA, Goodnick, PJ. Rapid cycling bipolar disorder. Expert Opinion on Pharmacotherapy. 2001; 2: 19631973.CrossRefGoogle ScholarPubMed
79.Arnone, D. Review of the use of Topiramate for treatment of psychiatric disorders. Annals of General Psychiatry 2005; 4: 5CrossRefGoogle ScholarPubMed
80.Ketter, TA, Wang, PW, Nowakowska, C, Marsh, WK. New medication treatment options for bipolar disorders. Acta Psychiatrica Scandinavica Supplementum 2004; 422: 1833.CrossRefGoogle Scholar
81.Yatham, LN, Kusumakar, V, Calabrese, JR, Rao, R, Scarrow, G, Kroeker, G. Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations. Journal of Clinical Psychiatry 2002; 63: 275283.CrossRefGoogle ScholarPubMed
82.Wang, PW, Ketter, TA, Becker, OV, Nowakowska, C. New anticonvulsant medication uses in bipolar disorder. CNS Spectrums 2003; 8: 941947.CrossRefGoogle ScholarPubMed