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Clozapine induced myocarditis: a case report and literature review

Published online by Cambridge University Press:  13 June 2014

Sunday O Okereke ,
Wan MY Mohd Abdoh  and
Bernadette M Murphy
Sunday O Okereke
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
Wan MY Mohd Abdoh
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
Bernadette M Murphy*
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
*
*Correspondence E-mail: [email protected]
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Abstract

Clozapine, the drug of choice for treatment resistant schizophrenia, has a range of serious cardiac side-effects. This paper describes a fatal case of myocarditis in a 48 year old man four weeks after starting clozapine. In particular, this case illustrates how incipient the disorder can be and the need for a high level of suspicion. Difficulties in diagnosing clozapine induced myocarditis and ways to minimise its risk are also discussed.

Keywords

ClozapineMyocarditisSchizophrenia
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 26 , Issue 3 , September 2009 , pp. 147 - 148
Copyright
Copyright © Cambridge University Press 2009

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References

1.Clozapine, SPC (Date of revision November 2005). Electronic Medicines Compendium (eMC). http://emc.medicines.org.uk (accessed 12 December 2008).Google Scholar
2.Merrill, DB, Dec, GW, Goff, DC. Adverse Cardiac Effects Associated With Clozapine. J Clin Psychopharmacol 2005; 25(1): 32–41.CrossRefGoogle ScholarPubMed
3.Meltzer, HY, Cola, P, Way, L, Thompson, PA, Bastani, B, Daves, MA, et al.Cost effectiveness of clozapine in neuroleptic-resistant schizophrenia. Am J Psych 1993; 150:1630–8.Google ScholarPubMed
4.Hass, SJ, Hill, R, Krum, H, Liew, D, Tonkin, A, Demos, L, et al.Clozapine-associated myocarditis: A review of 116 Cases of Suspected Myocarditis Associated with the use of Clozapine in Australia during 1993-2003. Drug Saf 2007; 30 (1): 47–57.CrossRefGoogle Scholar
5.Hagg, S, Spigseto, O, Bate, A, Soderstrom, TG. Myocarditis related to clozapine treatment. J Clin Psychopharmacol 2001; 21:382–8.CrossRefGoogle ScholarPubMed
6.Cooper, LT, editor, Myocarditis From Bench to Bedside. Humana Press 2002: 247–81.Google Scholar
7.Pieroni, M, Cavallaro, R, Chimenti, C, Smeraldi, E, Frustaci, A. Clozapine-induced hypersensitivity myocarditis. Chest 2004; 126: 1703–5.CrossRefGoogle ScholarPubMed