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Clozapine induced encephalopathy

Published online by Cambridge University Press:  13 June 2014

Michael J Hennessy ,
Catrin N Pugh ,
Charles M Wiles  and
Sarah E Watkins
Charles M Wiles
Affiliation:
Department of Neurology, University Hospital of Wales, Cardiff, Wales.
Sarah E Watkins
Affiliation:
Department of Psychiatry, Whitchurch Hospital, Cardiff, Wales.
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Abstract

Clozapine has become a widely used drug in therapyresistant schizophrenia and, increasingly, in the levodopa-induced dyskinesias and the psychoses of chronic Parkinson's disease. We report the case of a 43 year old male patient who developed a reversible encephalopathy associated with clozapine therapy.

Keywords

ClozapineMyoclonusEncephalopathy.
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 15 , Issue 1 , March 1998 , pp. 29 - 30
Copyright
Copyright © Cambridge University Press 1998

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References

1.Folstein, M, Folstein, S, McHugh, S. Mini-Mental State: a practical method for grading the cognitive status of patients for the clinician. J Psychiatric Res 1975; 12: 189–98.CrossRefGoogle Scholar
2.Thatcher, GW, Cates, M, Bair, B. Clozapine-induced toxic hepatitis (letter; comment). Am J Psychiatry 1995; 152(2): 296–7.Google Scholar
3.Marinkovic, D, Timotijevic, I, Babinsky, Tet al.The side effects of clozapine: a four year follow-up study. Prog Neuropsychopharmacol Biol Psychiatry. 1994 18(3): 537–44.CrossRefGoogle ScholarPubMed
4.Klawans, HL, Carvey, PM, Tanner, CM, et, al. Drug induced myoclonus. In: Fahn, S, Marsden, CD, VanWoert, M eds. Myoclonus: advances in neurology. Vol 43. New York, NY: Raven Press, 1986: 251–264.Google Scholar
5.Bak, TH, Bauer, M, Schaub, RT, Hellweg, R, Reischies, FM. Myoclonus in patients treated with clozapine-a case series. J Clin Psychiatry 1995: 56(9): 418–22.Google Scholar
6.Pacia, SV, Devinsky, O. Clozapine-related seizures: experience with 5,629 patients. Neurology 1994; 44, 2247–9.CrossRefGoogle Scholar
7.Welch, J, Manschreck, T, Redmond, D. Clozapine-induced seizures and EEG changes. J Neuropsychiatry Clin Neurosci 1994; 6(3): 250–6.Google ScholarPubMed
8.Gouloulis, E, Ozdaglar, A, Kasper, J. Myoclonic seizures followed by grand mal seizures during clozapine treatment, (letter). Am J Psychiatry 1993; 150: 1, 28.Google Scholar
9.Berman, J, Zalma, A, Du Rand, CJet al.Clozapine-induced myoclonic jerks and drop attacks (letter). J Clin Psychiatry 1992; 53: 329–330.Google Scholar
10.Risby, ED, Epstein, CM, Jewart, RDet al.Clozapine-induced EEG abnormalities and clinical response to clozapine. J Neuropsychiatry Clin Neurosci 1995; 466–70.Google ScholarPubMed
11.Denney, D, Stevens, JR. Clozapine and seizures. Biol Psychiatry 1995; 37(7): 427–33.CrossRefGoogle ScholarPubMed
12.Baldessarini, RJ, Huston-Lyons, D, Campbell, Aet al.Do central anti-adrenergic actions contribute to the atypical properties of clozapine? Br J Psychiatry 1992; (suppl): 12–16.CrossRefGoogle Scholar
13.Bharucha, KJ, Zamrini, E, Evans, Det al.Clozapine-induced asterixis (abstract). Neurology 1996; 46 (2)(suppl): A 262.Google Scholar