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Bipolar affective disorder and thrombocytopenia

Published online by Cambridge University Press:  13 June 2014

Timothy Evans
Affiliation:
Jobswell House, St David's Hospital, Carmarthen, Dyfed, SA31 3HB, South Wales, United Kingdom
Philip D Marshall
Affiliation:
Cefn Coed Hospital, Swansea SA2 OGH, South Wales, United Kingdom

Abstract

This report describes the case of a 62 year old man with late onset bipolar affective disorder whose mood swings were associated with episodes of thrombocytopenia. The inter-relationships between affective symptoms, the immune system and the hypothalamic pituitary axis are discussed.

Type
Case Reports
Copyright
Copyright © Cambridge University Press 1995

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References

1.Chawla, M, Lindesay, J. Polycythaemia, delirium and mania. Br J Psychiatry 1993; 162: 833–5.CrossRefGoogle ScholarPubMed
2.Mazzoli, M, Benazzi, F. Polycythaemia and psychotic depression. Br J Psychiatry 1992; 160: 134–55.CrossRefGoogle ScholarPubMed
3.Darko, DF, Lucas, AH, Gillin, JC, Risch, SC, et al.Cellular immunity and the hypothalmic pituitary axis in major affective disorder: a preliminary study. Psychiatry Research 1988; 25: 19.CrossRefGoogle Scholar
4.Altshuler, LL, Plaeger-Marshall, S, Richeimer, S, Daniels, M, et al.Lymphocyte function in major depression. ACTA Psychiatr Scand 1989; 80: 132–6.CrossRefGoogle ScholarPubMed
5.Cabranes-Diaz, JA, Almoguera, I, Ayuso, JL, Garcia-Camba, E, et al.Basal hypersecrection of Cortisol in relation to abnormal dexamethasone suppression test response in depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 1986; 10(6): 729–37.CrossRefGoogle Scholar
6.Lim, L, Ron, MA, Ormerod, IEC, David, J, et al.Psychiatric and neurological manifestations in systemic lupus erythematosus. Quart J Med 1988; 66: 2738.Google ScholarPubMed
7.Krauthammer, C, Klerman, GL. Secondary mania: manic syndromes associated with antecedent physical illness or drugs. Arch Gen Psychiatry 1978; 35: 1332–9.CrossRefGoogle ScholarPubMed
8.Cook, BL, Shukla, S, Hoff, AL. EEG abnormalities in bipolar affective disorder. J Affect Dis 1986; 11: 147–9.CrossRefGoogle ScholarPubMed
9.Kulisevsky, J, Berthier, ML, Pujol, J. Hemiballismus and secondary mania following a right thalamic infarction. Neurology 1993; 43 (7): 1422–4.CrossRefGoogle ScholarPubMed
10.Lowy, MT, Gormley, GJ, Reder, AT, Meltzer, HY. Immune function, glucocorticoid receptor regulation and depression. In: Miller, AH, editor. Depressive disorders and immunity. Washington: American Psychiatric Press Inc., 1989.Google Scholar
11.Whalley, LJ, Borthwick, N, Copolov, D, Dick, H, et al.Corticosteroid receptors and depression. BMJ 1986; 292: 859–61.CrossRefGoogle ScholarPubMed
12.Cookson, JC, Silverstone, T, Williams, S, Besser, GM. Plasma Cortisol levels in mania: associated clinic ratings and changes during treatment with Haloperidol. Br J Psychiatry 1985; 146: 498502.CrossRefGoogle ScholarPubMed
13.Muller, N, Hofschuster, E, Ackenheil, M, Mempel, W, et al.Investigations of the cellular immunity during depression and the free interval. Evidence for immune activation in affective psychosis. Progress in Neuropsychopharmacology and Biological Psychiatry 1993; 17(5): 713–30.CrossRefGoogle ScholarPubMed
14.Garcia-Seville, JA, Guimon, J, Garcia-Vallejo, P, Fuster, MJ. Biochemical and functional evidence of supersensitive platelet alpha 2 adrenoceptors in major affective disorder. Effects of long term lithium carbonate treatment. Arch Gen Psychiatry 1986; 43: 51–7.CrossRefGoogle Scholar
15.Garver, DL, Pandey, GN, Dekirmenjian, H, Deleon-Jones, F. Growth hormone und catecholamines in affective disorder. Am J Psychiatry 1975; 132: 11, 1149.Google Scholar