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Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease

Published online by Cambridge University Press:  11 November 2015

Otávio Augusto Fernandes Marques Bianco ,
Patrícia Regina Manzine ,
Carla Manuela Crispim Nascimento ,
Francisco Assis Carvalho Vale ,
Sofia Cristina Iost Pavarini  and
Márcia Regina Cominetti
Otávio Augusto Fernandes Marques Bianco
Affiliation:
Department of Gerontology, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil
Patrícia Regina Manzine
Affiliation:
Department of Gerontology, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil
Carla Manuela Crispim Nascimento
Affiliation:
Department of Gerontology, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil
Francisco Assis Carvalho Vale
Affiliation:
Department of Medicine, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil
Sofia Cristina Iost Pavarini
Affiliation:
Department of Gerontology, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil
Márcia Regina Cominetti*
Affiliation:
Department of Gerontology, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil
*
Correspondence should be addressed to: Márcia Regina Cominetti, Departamento de Gerontologia, Universidade Federal de São Carlos, Rodovia Washington Luís, Km 235, São Carlos, SP, 13565–905, Brazil. Phone: +55-16-3306 6663; Fax: +55-16-3351-9628. Email: [email protected].
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Abstract

Background:

Studies have demonstrated a decreased platelet ADAM10 expression in patients with Alzheimer's Disease (AD), classifying this protein as a blood-based AD biomarker. About 50% of the patients with AD are diagnosed with depression, which is commonly treated with tricyclic and tetracyclic antidepressants, monoaminoxidade (MAO) inhibitors and, more preferably, with selective serotonin reuptake inhibitors (SSRIs). Considering that a large proportion of patients with AD takes antidepressant medications during the course of the disease we investigated the influence of this medication on the expression of platelet ADAM10, which is considered the main α-secretase preventing beta-amyloid (βA) formation.

Methods:

Blood was collected for protein extraction from platelets. ADAM10 was analyzed by using western blotting and reactive bands were measured using β-actin as endogenous control.

Results:

Platelet ADAM10 protein expression in patients with AD was positively influenced by serotoninergic medication.

Conclusion:

More studies on the positive effects of serotonergic antidepressants on ADAM10 platelet expression should be performed in order to understand its biological mechanisms and to verify whether these effects are reflected in the central nervous system. This work represents an important advance for the study of AD biomarkers, as well as for more effective pharmacological treatment of patients with AD and associated depression.

Keywords

antidepressant drugsAlzheimer’s diseasebiomarkersdementiadepressionhuman ADAM10 protein
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 6 , June 2016 , pp. 939 - 944
Copyright
Copyright © International Psychogeriatric Association 2015 

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