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Seasonal Distribution of Births in Alzheimer's Disease

Published online by Cambridge University Press:  07 January 2005

Maurice W. Dysken ,
Michael Kuskowski ,
Stacy S. Skare ,
Uros Roessmann ,
Avertano Noronha  and
William H. Frey
Maurice W. Dysken
Affiliation:
Geriatric Research, Education, and Clinical Center, Minneapolis VA Medical Center, Minneapolis, Minnesota, U.S.A. Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Michael Kuskowski
Affiliation:
Geriatric Research, Education, and Clinical Center, Minneapolis VA Medical Center, Minneapolis, Minnesota, U.S.A.
Stacy S. Skare
Affiliation:
Geriatric Research, Education, and Clinical Center, Minneapolis VA Medical Center, Minneapolis, Minnesota, U.S.A.
Uros Roessmann
Affiliation:
Geriatric Research, Education, and Clinical Center, Minneapolis VA Medical Center, Minneapolis, Minnesota, U.S.A. Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio, U.S.A.
Avertano Noronha
Affiliation:
Geriatric Research, Education, and Clinical Center, Minneapolis VA Medical Center, Minneapolis, Minnesota, U.S.A. Department of Neurology, University of Chicago, Illinois, U.S.A.
William H. Frey
Affiliation:
Geriatric Research, Education, and Clinical Center, Minneapolis VA Medical Center, Minneapolis, Minnesota, U.S.A. Psychiatry Research Laboratories, Ramsey Ciinic/St. Paul – Ramsey Medical Center, Minnesota, U.S.A.
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Abstract

We obtained season-of-birth data in 727 autopsy-confirmed cases of Alzheimer's Disease (AD) and compared these data with expected general population birth rates. There were no significant differences between quarterly birth rates in the AD group and expected quarterly birth rates. Edward's test for cyclical trends did not establish a peak period of birth in the AD sample. No significant differences between observed and expected quarterly birth rates were found when data were analyzed with regard to either family history of dementia or to gender. Edward's test for peak quarter was significant for AD females, however, with the peak period occurring early in the first quarter. These negative findings between observed and expected quarterly birth rates, based on the large number of autopsy-confirmed AD cases in this study, suggest that a season-of-birth effect in AD is highly unlikely.

Type
Research and Reviews
Information
International Psychogeriatrics , Volume 3 , Issue 1 , March 1991 , pp. 53 - 58
Copyright
© 1991 Springer Publishing Company

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