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S6: Junior Research Award Winner: Cognitive impairment and Dementia in Latin American Individuals with Parkinsonism and Parkinson’s Disease: A 10/66 Dementia Research Group Study - Jorge Jesus L. Llibre-Guerra, MD

Published online by Cambridge University Press:  27 November 2024

JJ Llibre-Guerra ,
N Khan ,
MM Arruabarrena ,
DJ Kim ,
M Jiang ,
JJ Llibre-Rodriguez ,
AM Rodriguez-Salgado ,
I Acosta ,
AL Sosa  and
D Acosta
...Show all authors
JJ Llibre-Guerra
Affiliation:
Department of Neurology, Washington University in Saint Louis. Saint Louis, MO 63108
N Khan
Affiliation:
Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
MM Arruabarrena
Affiliation:
Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
DJ Kim
Affiliation:
Health Service and Population Research Department, Institute of Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, United Kingdom
M Jiang
Affiliation:
Institute of Public Health, Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
JJ Llibre-Rodriguez
Affiliation:
Dementia Research Unit, Medical University of Havana, Havana, Cuba
AM Rodriguez-Salgado
Affiliation:
Global Brain Health Institute, University of San Francisco California, San Francisco, CA 94117
I Acosta
Affiliation:
Laboratory of the Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico National Autonomous University of Mexico, Mexico City, Mexico
AL Sosa
Affiliation:
Laboratory of the Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico National Autonomous University of Mexico, Mexico City, Mexico
D Acosta
Affiliation:
Universidad Nacional Pedro Henriquez Ureña (UNPHU), Internal Medicine Department, Geriatric Section, Santo Domingo, Dominican Republic
IZ Jimenez-Velasquez
Affiliation:
Internal Medicine Department, Geriatrics Program, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico
M Guerra
Affiliation:
Instituto de la Memoria Depresion y Enfermedades de Riesgo IMEDER, Lima, Perú
A Salas
Affiliation:
Medicine Department, Caracas University Hospital, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela
R López-Contreras
Affiliation:
Memory Clinic, Neurology Service, Salvadoran Social Security Institute, San Salvador, El Salvador
Santana Dhara
Affiliation:
Department of Neurology, Hospital Félix María Goico, Santo Domingo, Dominican Republic.
Solorzano Joel
Affiliation:
Department of Medicine, Hospital Antonio Luaces Iralola, Ciegode Avila, Cuba.
C Jeyachandran
Affiliation:
Faculty of Medicine and Health, University of New South Wales, Sydney 1466, Australia.
H Hesse
Affiliation:
Observatorio Covid-19, Universidad Tecnológica Centroamericana, Honduras
C Tanner
Affiliation:
Department of Neurology, Weill Institute for Neurosciences, University of California- San Francisco, San Francisco, CA94117
M Prina
Affiliation:
Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
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Abstract

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Background: Limited knowledge exists about the association between Parkinsonism or Parkinson’s disease (PD) and cognitive impairment and dementia in Latin America.

Objectives: The study aimed to determine the cross-sectional and prospective associations between Parkinsonism and PD with cognitive impairment and dementia in a large multi-country cohort in Latin America.

Methods: The 10/66 is a prospective, observational cohort study. This population-based cohort study was based in six Latin American countries: Cuba, Dominican Republic, Puerto Rico, Venezuela, Mexico, and Peru. The study includes 12,865 participants from six countries, including residents aged 65 years and living in urban and rural catchment areas. Exposures included diagnosed Parkinsonism and PD defined according to the United Kingdom Parkinson’s Disease Society Brain Bank diagnostic criteria. Cognitive impairment was the main outcome measure for cross-sectional analysis and dementia was used to measure the prospective association with the exposures. Logistic regression models were used to explore the association between Parkinsonism/PD with cognitive impairment at baseline. Competing risk models were used to assess the prospective association between Parkinsonism/PD with incident dementia accounting for competing risk of mortality. Individual country analyses were combined via fixed-effect meta-analysis.

Results: At baseline, the prevalence of cognitive impairment in people with Parkinsonism and PD was 30% and 26.2%, respectively. Parkinsonism (OR 2.2 (95%CI 1.9 – 2.6)) and PD (1.9 (95%CI 1.4 – 2.4)) were individually associated with baseline and incident cognitive impairment after accounting for age, sex, and education, after pooling. In competing risk models, the pooled sub- hazard ratios for dementia in the fixed effect metanalysis were 1.5 (95%CI 1.2 – 1.9) for parkinsonism and 1.5 (95%CI 1.0 – 2.2) for PD.

Conclusions: Parkinsonism and PD were cross-sectionally associated with cognitive impairment and prospectively associated with incident dementia in Latin America. Routine screening for cognitive impairment and dementia with validated tools in PD patients may aid earlier detection of those at greater risk ofadverseoutcomes.

Type
Symposia
Information
International Psychogeriatrics , Volume 36 , Issue S1 , September 2024 , pp. 15 - 16
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of International Psychogeriatric Association