Objectives: The increase in suicidal behavior in patients treated with promising new drugs for Alzheimer’s disease is a dilemma that deserves to be understood. The correlations between suicide and neurodegenerative disorders have been debated for decades in the context of ethics, considering that many people with cognitive decline have opted for euthanasia. The academic community is invited to pay greater attention to issues other than ethics that can improve the quality of life of people with dementia.

Methods: We sought to read the review articles on Pubmed on the topic over the last two decades to identify possible factors that are correlating suicide with Alzheimer’s Disease. The data were grouped and presented to demonstrate possible studies that should be carried out to clarify the topic better.

Results: Depression and the presence of the E4 allele of Apolipoprotein E were the main correlation factors between Alzheimer’s disease and suicide.

Conclusions: Targeted studies are needed to understand better the occurrence of depression in Alzheimer’s disease, as well as the role of the E4 allele in mood disorders and suicidal behavior.