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The Influence of Age-Dependent Pharmacokinetics on the Pharmacodynamics of Hypnotic Drugs: Comparison of Two Hypnotics with Different Half-Lives

Published online by Cambridge University Press:  07 January 2005

M. Bergener ,
R. Gola  and
C. Hesse
M. Bergener
Affiliation:
Rheinische Landesklinik Köln, Federal Republic of Germany
R. Gola
Affiliation:
Rheinische Landesklinik Köln, Federal Republic of Germany
C. Hesse
Affiliation:
Rheinische Landesklinik Köln, Federal Republic of Germany
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Abstract

Drugs with a short elimination half-life should display fewer side effects than longer acting drugs in the treatment of sleep disturbances due to their smaller tendency to accumulate, especially in the elderly. This hypothesis could be confirmed in a double blind study of zopiclone versus flurazepam.

Type
Research and Reviews
Information
International Psychogeriatrics , Volume 1 , Issue 1 , March 1989 , pp. 17 - 29
Copyright
© 1989 Springer Publishing Company

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