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Frequency and risk factors for HIV-associated neurocognitive disorder and depression in older individuals with HIV in northeastern Brazil

Published online by Cambridge University Press:  22 May 2012

Sérgio Murilo Maciel Fernandes Filho  and
Heloísa Ramos Lacerda de Melo
Sérgio Murilo Maciel Fernandes Filho*
Affiliation:
Postgraduate Program in Health Sciences, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil Hospital Getulio Vargas, Recife, Pernambuco, Brazil
Heloísa Ramos Lacerda de Melo
Affiliation:
Postgraduate Program in Health Sciences, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil Postgraduate Program in Tropical Medicine, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil
*
Correspondence should be addressed to: Sérgio Murilo Maciel Fernandes Filho, Hospital Getúlio Vargas, Avenida General San Martin, S/N. CEP: 50630-060 Recife, PE, Brazil. Phone: +55 81 31845861; Fax: +55 81 31845861. Email: [email protected].
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Abstract

Background: The study was undertaken to describe the frequency of HIV-associated neurocognitive disorders (HAND) and depressive symptoms in an older population with human immunodeficiency virus (HIV).

Methods: A cross-sectional analysis of patients aged 50 years or older infected with HIV was carried out in an outpatient setting in Brazil from March to November 2008. Patients selected were submitted to cognitive evaluation using the Mini-Mental State Examination and International HIV Dementia Scale, and also to functional and depression evaluations.

Results: Among the 52 patients evaluated, the frequency of neurocognitive disorder was 36.5%, while for dementia the frequency was 13.5%. No risk factors were identified. Among the patients with cognitive impairment, 73.7% had cortical impairment. The frequency of depressive symptoms was of 34.6%. The female gender was identified as a risk factor (p = 0.018) and patients with depressive symptoms had greater functional impairment (p < 0.001).

Conclusion: HAND and depressive symptoms are common in an older population. Patients with cognitive impairment achieved lower scores on the cortical assessment scales. Depressive symptoms are a stronger factor for functional impairment.

Keywords

AIDS dementia complexHIV infectiondementiaaged
Type
Research Article
Information
International Psychogeriatrics , Volume 24 , Issue 10 , October 2012 , pp. 1648 - 1655
Copyright
Copyright © International Psychogeriatric Association 2012

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