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Early and recent psychosocial stress and telomere length in older adults

Published online by Cambridge University Press:  12 August 2015

Roxanne Schaakxs ,
Ilse Wielaard ,
Josine E. Verhoeven ,
Aartjan T. F. Beekman ,
Brenda W. J. H. Penninx  and
Hannie C. Comijs
Roxanne Schaakxs*
Affiliation:
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, PO Box 74077, 1070 BB Amsterdam, the Netherlands
Ilse Wielaard
Affiliation:
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, PO Box 74077, 1070 BB Amsterdam, the Netherlands
Josine E. Verhoeven
Affiliation:
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, PO Box 74077, 1070 BB Amsterdam, the Netherlands
Aartjan T. F. Beekman
Affiliation:
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, PO Box 74077, 1070 BB Amsterdam, the Netherlands
Brenda W. J. H. Penninx
Affiliation:
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, PO Box 74077, 1070 BB Amsterdam, the Netherlands
Hannie C. Comijs
Affiliation:
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands, PO Box 74077, 1070 BB Amsterdam, the Netherlands
*
Correspondence should be addressed to: Roxanne Schaakxs, PO Box 74077, 1070 BB Amsterdam, the Netherlands. Phone: (+31) 020-7884521. Email: [email protected].
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Abstract

Background:

Psychosocial stress has been associated with an increased risk for mental and somatic health problems across the life span. Some studies in younger adults linked this to accelerated cellular aging, indexed by shortened telomere length (TL). In older adults, the impact of psychosocial stress on TL may be different due to the lifetime exposure to competing causes of TL-shortening. This study aims to assess whether early and recent psychosocial stressors (childhood abuse, childhood adverse events, recent negative life events, and loneliness) were associated with TL in older adults.

Methods:

Data were from the Netherlands Study of Depression in Older Persons (NESDO) in which psychosocial stressors were measured in 496 persons aged 60 and older (mean age 70.6 (SD 7.4) years) during a face-to-face interview. Leukocyte TL was determined using fasting blood samples by performing quantitative polymerase chain reaction (qPCR) and was expressed in base pairs (bp).

Results:

Multiple regression analyses, adjusted for age, sex, and chronic diseases, showed that childhood abuse, recent negative life events and loneliness were unrelated to TL. Only having experienced any childhood adverse event was weakly but significantly negatively associated with TL.

Conclusions:

Our findings did not consistently confirm our hypothesis that psychosocial stress is associated with shorter TL in older adults. Healthy survivorship or other TL-damaging factors such as somatic health problems seem to dominate a potential effect of psychosocial stress on TL in older adults.

Keywords

psychosocial stresschildhood abusenegative life eventslonelinesscellular agingtelomere lengthtelomere shortening
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 3 , March 2016 , pp. 405 - 413
Copyright
Copyright © International Psychogeriatric Association 2015 

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References

American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington, DC: American Psychiatric Association.Google Scholar
Bartoli, F., Carrà, G., Crocamo, C., Carretta, D. and Clerici, M. (2013). Metabolic syndrome in people suffering from posttraumatic stress disorder: a systematic review and meta-analysis. Metabolic Syndrome and Related Disorders, 11, 301–308. doi: 10.1089/met.2013.0010.Google Scholar
Blackburn, E. H. (2001). Switching and signaling at the telomere. Cell, 106, 661–673. doi: 10.1016/S0092-8674(01)00492-5.CrossRefGoogle ScholarPubMed
Blackburn, E. H., Greider, C. W. and Szostak, J. W. (2006). Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nature Medicine, 12, 1133–1138. doi:10.1038/nm1006-1133.Google Scholar
Brugha, T., Bebbington, P., Tennant, C. and Hurry, J. (1985). The list of threatening experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychological Medicine, 15, 189–194. doi: 10.1017/S003329170002105X.Google Scholar
Carroll, J. E., Diez Roux, A. V., Fitzpatrick, A. L. and Seeman, T. (2013). Low social support is associated with shorter leukocyte telomere length in late life: multi-ethnic study of atherosclerosis. Psychosomatic Medicine, 75, 171–177. doi: 10.1097/PSY.0b013e31828233bf.Google Scholar
Comijs, H. C., Beekman, A. T., Smit, F., Bremmer, M., van Tilburg, T. and Deeg, D. J. (2007). Childhood adversity, recent life events and depression in late life. Journal of Affective Disorders, 103, 243–246. doi: 10.1016/j.jad.2007.01.012.Google Scholar
Comijs, H. C., van Exel, E., van der Mast, R. C., Paauw, A., Oude Voshaar, R. and Stek, M. L. (2013). Childhood abuse in late-life depression. Journal of Affective Disorders, 147, 241–246. doi: 10.1016/j.jad.2012.11.010.CrossRefGoogle ScholarPubMed
Comijs, H. C. et al. (2011). The Netherlands study depression in older persons (NESDO); a prospective cohort study. BMC Research Notes, 4, 524. doi: 10.1186/1756-0500-4-524.Google Scholar
Daniali, L. et al. (2013). Telomeres shorten at equivalent rates in somatic tissues of adults. Nature Communications, 4, 1597. doi: 10.1038/ncomms2602.Google Scholar
De Graaf, R., Bijl, R. V., Ten Have, M., Beekman, A. T. F. and Vollebergh, W. A. M. (2004). Pathways to comorbidity: the transition of pure mood, anxiety and substance use disorders into comorbid conditions in a longitudinal population-based study. Journal of Affective Disorders, 82, 461–467. doi: 10.1016/j.jad.2004.03.001.CrossRefGoogle Scholar
De Jong-Gierveld, J. and Kamphuls, F. (1985). The development of a rasch-type loneliness scale. Applied Psychological Measurement, 9, 289–299. doi: 10.1177/014662168500900307.Google Scholar
Epel, E. S. et al. (2004). Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences of the United States of America, 101, 17312–17315. doi: http://dx.doi.org/10.1073/pnas.0407162101.Google Scholar
Fitzpatrick, A. L. et al. (2007). Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. American Journal of Epidemiology, 165, 14–21. doi: 10.1093/aje/kwj346.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-Mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198. doi: 10.1016/0022-3956(75)90026-6.CrossRefGoogle Scholar
Geenen, R., Van Middendorp, H. and Bijlsma, J. W. J. (2006). The impact of stressors on health status and hypothalamic-pituitary-adrenal axis and autonomic nervous system responsiveness in rheumatoid arthritis. Annals of the New York Academy of Sciences, 1069, 77–97. doi: 10.1196/annals.1351.007.Google Scholar
Glass, D., Parts, L., Knowles, D., Aviv, A. and Spector, T. D. (2010). No correlation between childhood maltreatment and telomere length. Biological Psychiatry, 68, e21. doi: 10.1016/j.biopsych.2010.02.026.Google Scholar
Hardt, J. and Rutter, M. (2004). Validity of adult retrospective reports of adverse childhood experiences: review of the evidence. Journal of Child Psychology and Psychiatry, 45, 260–273. doi: 10.1111/j.1469-7610.2004.00218.x.Google Scholar
Holt-Lunstad, J., Smith, T. B., Baker, M., Harris, T. and Stephenson, D. (2015). Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspectives on Psychological Science, 10, 227–237. doi: 10.1177/1745691614568352.CrossRefGoogle ScholarPubMed
Hovens, J. G. et al. (2010). Childhood life events and childhood trauma in adult patients with depressive, anxiety and comorbid disorders versus controls. Acta Psychiatrica Scandinavica, 122, 66–74. doi: 10.1111/j.1600-0447.2009.01491.x.Google Scholar
Kananen, L. et al. (2010). Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PloS One, 5, p.e10826. doi: 10.1371/journal.pone.0010826.CrossRefGoogle ScholarPubMed
Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q. and Glaser, R. (2011). Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosomatic Medicine, 73, 16–22. doi: 10.1097/PSY.0b013e31820573b6.Google Scholar
Lacey, R. E., Kumari, M. and McMunn, A. (2013). Parental separation in childhood and adult inflammation: the importance of material and psychosocial pathways. Psychoneuroendocrinology, 38, 2476–2484. doi: 10.1016/j.psyneuen.2013.05.007.Google Scholar
Lin, J. et al. (2010). Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. Journal of Immunological Methods, 352, 71–80. doi: 10.1016/j.jim.2009.09.012.Google Scholar
Midei, A. J., Matthews, K. A., Chang, Y.-F. and Bromberger, J. T. (2013). Childhood physical abuse is associated with incident metabolic syndrome in mid-life women. Health Psychology, 32, 121–127. doi: 10.1037/a0027891.Google Scholar
Puterman, E., Lin, J., Krauss, J., Blackburn, E. H. and Epel, E. S. (2015). Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter. Molecular Psychiatry, 20, 529–535. doi: 10.1038/mp.2014.70.Google Scholar
Richardson, S., Shaffer, J. A., Falzon, L., Krupka, D., Davidson, K. W. and Edmondson, D. (2012). Meta-analysis of perceived stress and its association with incident coronary heart disease. American Journal of Cardiology, 110, 1711–1716. doi: 10.1016/j.amjcard.2012.08.004.Google Scholar
Russ, T. C., Stamatakis, E., Hamer, M., Starr, J. M., Kivimäki, M. and Batty, G. D. (2012). Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies. BMJ, 345, p. e4933. doi: 10.1136 /bmj.e4933.Google Scholar
Savolainen, K. et al. (2014). Associations between early life stress, self-reported traumatic experiences across the lifespan and leukocyte telomere length in elderly adults. Biological Psychology, 97, 35–42. doi: 10.1016/j.biopsycho.2014.02.002.Google Scholar
Schaakxs, R., Verhoeven, J. E., Comijs, H. C., Oude Voshaar, R. C. and Penninx, B. W. J. H. (2015). Leukocyte telomere length and late-life depression. American Journal of Geriatric Psychiatry, 23, 423–432. doi: 10.1016/j.jagp.2014.06.003.Google Scholar
Schüssler-Fiorenza Rose, S. M., Xie, D. and Stineman, M. (2014). Adverse childhood experiences and disability in U.S. adults. PM&R: The Journal of Injury, Function, and Rehabilitation, 6, 670–680. doi: 10.1016/j.pmrj.2014.01.013.Google Scholar
Segerstrom, S. C. and Miller, G. E. (2004). Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130, 601–630. doi: 10.1037/0033-2909.130.4.601.Google Scholar
Surtees, P. G. et al. (2011). Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)-norfolk population study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66, 1152–1162. doi: 10.1093/gerona/glr112.Google Scholar
Tyrka, A. R., Price, L. H., Kao, H. T., Porton, B., Marsella, S. A. and Carpenter, L. L. (2010). Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biological Psychiatry, 67, 531–534. doi: 10.1016/j.biopsych.2009.08.014.Google Scholar
Verhoeven, J. E., Révész, D., Epel, E. S., Lin, J., Wolkowitz, O. M. and Penninx, B. W. (2014). Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Molecular Psychiatry, 19, 895–901. doi: 10.1038/mp.2013.151.Google Scholar
Verhoeven, J. E., Van Oppen, P., Puterman, E., Elzinga, B. and Penninx, B. W. J. H. (in press). The association of early and recent psychosocial life stress with leukocyte telomere length. Psychosomatic Medicine.Google Scholar
Willeit, P. et al. (2010). Telomere length and risk of incident cancer and cancer mortality. JAMA, 304, 69–75. doi: 10.1001/jama.2010.897.Google Scholar
Wilson, R. S. et al. (2007). Loneliness and risk of Alzheimer disease. Archives of General Psychiatry, 64, 234–240. doi: 10.1001/archpsyc.64.2.234.Google Scholar
Wittchen, H. U. (1994). Reliability and validity studies of the WHO—composite international diagnostic interview (CIDI): a critical review. Journal of Psychiatric Research, 28, 57–84. doi: 10.1016/0022-3956(94)90036-1.Google Scholar
Wolkowitz, O. M., Epel, E. S., Reus, V. I. and Mellon, S. H. (2010). Depression gets old fast: do stress and depression accelerate cell aging? Depression and Anxiety, 27, 327–338. doi: 10.1002/da.20686.Google Scholar