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Comparison of structural connectivity in Parkinson's disease with depressive symptoms versus non-depressed: a diffusion MRI connectometry study

Published online by Cambridge University Press:  21 March 2018

Mina Ansari ,
Sahand Adib Moradi ,
Farzaneh Ghazi Sherbaf ,
Abozar Hedayatnia  and
Mohammad Hadi Aarabi Open the ORCID record for Mohammad Hadi Aarabi [Opens in a new window]
Mina Ansari
Affiliation:
Neuroimaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Sahand Adib Moradi
Affiliation:
Neuroimaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Farzaneh Ghazi Sherbaf
Affiliation:
Neuroimaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Abozar Hedayatnia
Affiliation:
Neuroimaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Mohammad Hadi Aarabi*
Affiliation:
Neuroimaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
*
Correspondence should be addressed to: Mohammad Hadi Aarabi, Neuroimaging Network (NIN), Universal Scientific Education and Research Network (USERN) Office, Children's Medical Center Hospital, Dr. Qarib Street, Keshavarz Blvd, Tehran 14194, Iran. Phone: +98-21-6692-9234. Email: [email protected].
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Abstract

Objective:

Research on psychobiological markers of Parkinson's disease (PD) remains a hot topic. Non-motor symptoms such as depression and REM sleep behavior disorder (RBD) each attribute to a particular neurodegenerative cluster in PD, and might enlighten the way for early prediction/detection of PD. The neuropathology of mood disturbances remains unclear. In fact, a few studies have investigated depression using diffusion magnetic resonance imaging (diffusion MRI).

Method:

Diffusion MRI of PD patients without comorbid RBD was used to assess whether microstructural abnormalities are detectable in the brain of 40 PD patients with depression compared to 19 patients without depression. Diffusion MRI connectometry was used to carry out group analysis between age- and gender-matched PD patients with and without depressive symptoms. Diffusion MRI connectometry is based on spin distribution function, which quantifies the density of diffusing water and is a sensitive and specific analytical method to psychological differences between groups.

Results:

A significant difference (FDR = 0.016129) was observed in the left and right uncinate fasciculi, left and right inferior longitudinal fasciculi, left and right fornices, left inferior fronto-occipital fasciculus, right corticospinal tract, genu of corpus callosum, and middle cerebellar peduncle.

Conclusion:

These results suggest the prominent circuits involved in emotion recognition, particularly negative emotions, might be impaired in comorbid depressive symptoms in PD.

Keywords

Parkinson's diseasedepressiondiffusion MRIconnectometry
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 1: Issue Theme: Parkinson's Disease , January 2019 , pp. 5 - 12
Copyright
Copyright © International Psychogeriatric Association 2018 

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Footnotes

*

Mina Ansari and Sahand Adib Moradi contributed equally to this work.

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